Abstract:In situ immunological and DNA probe-based histochemical detection methods have widespread,important biomedical applications in infectious and genetic disease diagnosis, neurobiology,developmental biology, pharmacology and other research. However, radioisotopic detection remains thepredominant method… more
Abstract:Helicobacter pylori is a gastrointestinal pathogen that causes, or is a major risk factor for thedevelopment of a spectrum of diseases including chronic gastritis, peptic ulcer, and cancer of thestomach. Current therapies for these diseases are inadequate as they are plagued with high… more
Abstract:ORBITEC proposes to develop an innovative Electromechanical Vibratory Tactile Stimulation (EVTS) system that will provide intuitive tactile, force, and torque feedback. The need for this type of feedback is growing, as manipulators become more dextrous, and more complex tasks are to be carried out… more
Abstract:PARKVIEW RESEARCH & DEVELOPMENT, INC., PROPOSES THE STUDY OF THREE-TERMINAL DEVICES BASED ON SMALL GRAIN THIN HTS FILMS AND STEP EDGE JUNCTION MATRICES. NEW CONFIGURATIONS AND MATERIALS THAT ARE BELIEVED TO SHOW HIGH MAGNETIC FIELD SENSITIVITY HAVE BEEN IDENTIFIED AND WILL BE EXPLORED. BECAUSE OF… more
Abstract:Biologically relevant environmental monitoring can be achieved using the genetic responses of microbes to environment conditions as sensors, particularly the specific and generalized responses to toxicity. The generalized toxicity response may be especially improtant when prior knowledge of the type… more
Abstract:Advanced aircraft designs require technology improvements that incorporate the use of advanced materials and material systems for high specific stiffness and temperature capabilities. Improved crack detection and material property measurement techniques are required to support the development and… more
Abstract:We will develop a novel system for directed nucleic acid cleavage. This system is based uponour discovery that the 5' nucleases of several thermostable DNA polymerases can be directed to cleaveas site-specific endonucleases. This system will be thermostable, specific, efficient and easilyautomatable… more
Abstract:Surgeons performing arthroplasty on painful, misshapen, arthritic hand joints do not have the choice of replacing the damaged joint with a prosthesis that will restore near natural movement as they would if a hip joint were being replaced. There are no effective finger joint replacements available.… more
Abstract:The presence of high concentrations of organic solvents constitutes an extreme environment for microorganisms, yet little work has been done to isolate or develop microorganisms suitable for use under such conditions. There is a need for solvent-resistant microorganisms for use in a variety of such… more
Abstract:We will develop a biosensor system for rapid detection of specific toxic metals and organic compounds in blood or urine. Chemical-specific biosensors are produced by fusing chemical-responsive regulatory genes and reporter lux genes. By transforming an appropriate host with the resulting fusion… more
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