Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a novel, commercially-viable, hybrid system that improves the adhesion of nanocrsytalline diamond (NCD) coatings to tungsten carbide (WC) cutting tools. A new hybrid system will be assembled, tested, and optimized.… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules, and can increase detection limits of conventional ELISAs by 100- to… more
Abstract:DESCRIPTION (provided by applicant): AquaMost is developing a water treatment device based on a technology called photoelectrocatalytic oxidation (PECO). The focus for this project is using PECO systems to treat groundwater contaminated with organic pollutants released from leaking underground… more
Abstract:DESCRIPTION (provided by applicant): Post translational modifications (PTMs) such as phosphorylation, glycosylation and methylation play a central and ubiquitous role in cellular signal transduction, and the enzymes that catalyze these reactions such as kinases and methyltransferases are the targets… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will fund a continuation of breakthrough research, development and commercialization of an in vitro assay to help prevent birth defects. This innovative product is driven by a need to create a test for human developmental toxicity that… more
Abstract:This Small Business Innovation Research Phase I project highlights a strategy for the development of the first integrated high throughput pipeline to synthesize and evaluate novel sugar-drug conjugates. The core innovation of this proposed phase I study is an enzyme catalyzed one-step glycosylation… more
Abstract:DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is among the most common and lethal cancers yet, the current standard of care for advanced stage NSCLC provides only modest improvements in overall survival or quality of life. Thus,there exists a significant unmet need for new… more
Abstract:DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNTs) are the most toxic substances known to humans, causing respiratory failure. Because of their lethality and ease of production, the Department of Defense (DoD) designates BoNTs as a categoryA bioterrorism agent. Developing effective,… more
Abstract:DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNT) are the most toxic substances known to humans, causing respiratory failure upon intoxication. Despite their lethality, BoNTs have clinical health and cosmetic applications and are currentlyFDA-approved for treating cervical dystonia,… more
Abstract:DESCRIPTION (provided by applicant): The need for evidence-based mental health treatments i.e., 'treatment based on the best available science or research evidence , has been stressed from scientific, ethical, and marketing perspectives. While empirical evidence supports both the efficacy and… more
Abstract:DESCRIPTION (provided by applicant): Psychiatric comorbidity is a major concern for adolescents with substance use or psychiatric disorders. Eighty-five percent of adolescents in treatment for a substance use disorder have an additional psychiatric comorbidity. Similarly, psychiatric disorders have… more
Abstract:DESCRIPTION (provided by applicant): Autism is a neurodevelopmental disorder characterized by deficits in social reciprocity, verbal and nonverbal communication, and behavior. It is among the most prevalent of all developmental disabilities, with an estimated prevalence of 1 in 110. Early detection… more
Abstract:DESCRIPTION (provided by APPLICANT): The need for evidence-based mental health treatments i.e., 'treatment based on the best available science or research evidence' 1, has been stressed from scientific, ethical, and marketing perspectives3. While empiricalevidence supports both the… more
Abstract:The proposed Phase II program seeks to demonstrate the feasibility of a patent-pending 6-cycle continuous combustion engine system technology that is a modification of existing 4-cycle engines to address engine related concerns in small generators as experienced by the United States Marine Corps and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project is aimed at developing an effective, inexpensive, safe means of controlling diseases in farm-raised catfish. One of the biggest problems in farm-raised catfish is disease that occurs in commercial ponds. Scientists at Auburn University… more
Abstract:DESCRIPTION (provided by applicant): Microfluidic systems are emerging as critically important tools for high throughput cell based analysis for applications including genotyping, sequencing, gene expression analysis, nucleic acid amplification, and diagnostics. Lab-on-a-chip devices that are… more
Abstract:DESCRIPTION (provided by applicant): The regulation of gene expression drives all biological processes. A thorough understanding of the mechanisms governing the patterns of gene expression is necessary to understand the fundamentals of biology and the complexities of cancers and other diseases. The… more
Abstract:DESCRIPTION (provided by applicant): There is societal need for new therapeutic agents in our arsenal of defenses against bacterial and fungal pathogens, many of which are increasingly resistant to existing antibiotics. Filamentous fungi are considered promising resources for the development of… more
Abstract:A system is designed to extract energy from background RF energy in the ambient due to radio and wireless communication sources. This energy is harvested on a continuous basis and stored on-board to provide power for anti tamper systems. This eliminates the need for maintenance of battery sources… more
Abstract:The number of distinct malware being released into the wild is growing at an alarming rate. Some IT security companies are seeing more than 5,000 new malware instances each day. IT security companies can no longer keep pace with this deluge using manual, labor-intensive malware analysis techniques… more
Abstract:The innovative High Efficiency, High Output Plastic Melt Waste Compactor (HEHO-PMWC) is a trash dewatering and volume reduction system that uses heat melt compaction to remove nearly 100% of water from trash and reduce the volume by up to 11 times. The HEHO-PMWC system incorporates novel methods to… more
Abstract:ORBITEC proposes to develop and test new, non-toxic ionic liquid fuels for propulsion applications. Vintage propulsion systems frequently use highly toxic propellants such as MMH. The toxicity of these propellants increases not only the risk of the missions but also the expense, due to special… more
Abstract:The overall objective of the Phase 1 effort was to demonstrate the technical feasibility of the Advanced Carbothermal Electric (ACE) Reactor concept. Unlike state-of-the-art carbothermal reactors that use concentrated solar energy and/or laser energy to heat the regolith, the ACE Reactor uses an… more
Abstract:ORBITEC proposes to develop a non-thermal technology based on atmospheric-pressure (AP) cold plasma to sanitize foods, food packaging materials, and other hardware and working surfaces that are encountered during food processing in space vehicles or habitats. AP plasma is well known to be highly… more
Abstract:ORBITEC proposes to develop, fabricate, and test a system to provide 99.999% hydrogen by efficiently performing methane pyrolysis. The system has three unique features: (1) the methane pyrolysis reactor that does not rely on high single-pass efficiencies (which will make the system robust), (2) it… more
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