Abstract:The technical objectives of this proposal are: 1) the design of 8 micron-emitting active-photonic-crystal (APC) quantum-cascade (QC) lasers by using passive phase-locking in a monolithic structure in order to achieve multiwatt-range, diffraction-limited powers; and 2) the development of the key… more
Abstract:DESCRIPTION (provided by applicant): Reducing Health Disparities: A Health IT Solution, proposes a collaborative effort to coordinate community stakeholders in Dane County, WI, to integrate a replicable and innovative health IT solution to overcome syste
mic barriers that exacerbate health… more
Recent National Assessment of Educational Progress reports indicate that high percentages of students – especially English Language Learners, those with reading deficiencies, and those with… more
Recent National Assessment of Educational Progress reports indicate that high percentages of students – especially English Language Learners, those with reading deficiencies, and those with learning… more
Abstract:DESCRIPTION (provided by applicant): The Alzheimer's Association 2009 Alzheimer's Disease Facts and Figures report indicates that as many as 5.3 million Americans suffer from Alzheimer disease (AD), and it costs the country about 148 billion a year to pro
vide care. AD triples healthcare costs for… more
Abstract:DESCRIPTION (provided by applicant): Calorie restriction (CR) is the only non-genetic intervention known to increase maximum lifespan and oppose a broad spectrum of age-related diseases including diabetes, sarcopenia, cardiovascular disease and cancer. A m
arked characteristic of animals subjected… more
Abstract:The majority of manufactured parts for defense system applications are machined using a lubricating cutting fluid. Field data has shown that cutting fluids not only impact tool life and piece geometry of manufactured parts, but can alter the power used by machine tools by 15% to 30%. Cutting fluid… more
Abstract:This SBIR Phase I project will develop a plan to use a protein normally produced in plants, to control phytopathogenic fungi. They have cloned a gene that encodes for this protein, expressed it in bacterial vectors, demonstrated activity against three phytopathogenic fungi, demonstrated activity on… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project offers a substantial improvement in the surgical treatment of cancer. The inability to find malignant tissue by sight or touch limits the tissue that the surgeon can identify and remove. Currently, removal of affected tissue must be… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will determine feasibility of developing a radically new mechanical-to-electrical energy conversion method which is based on reverse electrowetting - a recently discovered novel microfluidic phenomenon. The approach is targeted towards… more
Abstract:DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry, which are needed in clinical applications such as stereotactic radiosurgery/ stereotactic radiotherapy (SRS/SRT),
intensity modulated radiation therapy… more
Abstract:DESCRIPTION (provided by applicant): Hyperpolarized helium and xenon MRI of the lungs has been shown to provide useful physiological information about pulmonary function. Hyperpolarized helium imaging has been shown to provide outstanding imaging of lung g
as spaces while allowing for… more
Abstract:This Small Business Technology Transfer Phase I project will seek to improve the performance of the cathode materials used in lithium-ion (Li-ion) batteries. LiCoO2 is the primary cathode material, but it is relatively expensive, and has safety concerns. A safer alternative is LiMn2O4, but its… more
Abstract:This SBIR Phase I project will genetically engineer a thermophilic bacterial strain capable of expressing and secreting all the enzymes necessary for biomass hydrolysis and that can grow on minimal media in aerobic and anaerobic conditions. The National Energy Plan Renewable Fuel Standard mandates… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to improve the adhesion of nanocrystalline diamond coatings to micro-scale tungsten carbide cutting tools. Nanocrystalline diamond coatings have been shown to dramatically improve the machining performance of micro end mills. … more
Abstract:This SBIR Phase I project will test and develop the concept of enhancing the conversion of cellulose to glucose by providing the accessibility of the enzymes to the cellulose fibers at the nanoscale level. The project addresses a serious deficiency that currently exists in bio-fuels production from… more
Abstract:DESCRIPTION (provided by applicant): The ultimate goal of the proposed research is to develop a closed-loop process to significantly reduce the dispensing error rate for community pharmacies. In the proposed dispensing process, almost all initial medicatio
n filling errors will be caught by an… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a system that, while being inexpensive and simple to use, will be able to generate variable domains of heavy chain-only llama antibodies (also called VHHs, or nanobodies) targeted to antigens of interest in vitro… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project has a goal of creating a system that, while being inexpensive and simple to use, will be able to analyze samples for the presence of a live pathogenic bacteria and determine their species, as well as sensitivities to antibiotics within… more
Abstract:Current research tools to understand tumor cell migration and metastases are limited to linear gradients or constant flow across cells skewing results. Researchers at the National Institute of Standards and Technology developed a tool called the microfluidic palette which exposes cells to… more
Abstract:DESCRIPTION (provided by applicant): Key elements of tumorigenesis are driven by paracrine signaling between stromal and epithelial cells within the context of the extracellular matrix. Unfortunately, the cellular assays used for drug discovery typically r
ely on a single cell type grown as a… more
Abstract:DESCRIPTION (provided by applicant): There is a strong need for more predictive cellular assays that better represent the tissue that is under investigation. For airway epithelia such a model exists, and uses primary cells grown at an air liquid interface
(ALI). A key technical hurdle has been the… more
Abstract:The SPORL process consists of reacting wood chips with a solution of calcium, magnesium, or sulfite at elevated temperatures for a short time, and then size reducing the resulting material using a disk refiner to generate fibrous substrate for subsequent saccharification and fermentation. The work… more
Abstract:Brain tumor stem cells (BTSCs) are a subset population within tumors that are widely believed to be responsible for tumor recurrence, due to their ability to self-renew, differentiate, migrate, and initiate tumor propagation. Given these unique features, the selective targeting of… more
Abstract:CompuTherm, LLC proposes a pilot project to develop a modeling tool that can be used to assess the durability of environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) under combustion environment. This modeling tool is a package that integrates thermodynamic databases for the… more
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