Abstract:DESCRIPTION (provided by applicant): The National Cancer Institute projects that more than 1,000,000 cases of skin cancer will be diagnosed in the United States in 2008, including more than 62,000 new cases of melanoma. Although surgical excision of the pr
imary tumor is curative for the majority of… more
Abstract:Complex craniofacial tissue loss is a major medical problem affecting deployed military personnel. During the ongoing conflicts in Iraq and Afghanistan, approximately 88% of injured troops sustain severe blast-related injuries to their head and neck from improvised explosive devices. These severe… more
Abstract:DESCRIPTION (provided by applicant): Burns and trauma to the skin affect an estimated 1.25 million Americans each year. Extensive damage to the skin has serious repercussions, leading to dehydration, increased metabolic load, entry of toxic substances, immunosuppression, and wound infection.… more
Abstract:DESCRIPTION (provided by applicant): Chronic and infected wounds significantly affect the quality of life for millions of US citizens and are associated with increased risk of complications including the devastating consequence of amputation. As of 2006, i
nfections of diabetic foot ulcers resulted… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a full-thickness in vitro human skin model in a format enabling increased-throughput screening of compounds. The project will 1) develop culture conditions for production of fibroblast-derived dermal equivalents, 2)… more
Abstract:DESCRIPTION (provided by applicant): The goal of this STTR project is to develop innovative human tumor microenvironment (TM) assays for use as screening tools in the identification of new anti-tumor therapeutics. Novel assay technologies are needed for the discovery of new drugs, and combinations… more
Abstract:Summerdale, Inc. and Forest Products Laboratory (FPL) will focus on above-ground applications of waterborne preservatives for indoor and outdoor residential lumber. Specifically, fatty acid-based formulations +/- adjuvants will be targeted for use on a) indoor lumber and wood composites and b)… more
Abstract:DESCRIPTION (provided by applicant): Only 28% of all Americans are considered scientifically literate , a distressing figure that leaves 72% of U.S. citizens ill-prepared to comprehend the substance of important issues such as stem cell research, global
warming, or their own health-related… more
Abstract:DESCRIPTION (provided by applicant): The advent of next-generation (Next-gen) sequencing technologies has begun a surge in whole genome sequencing and resequencing, exemplified spectacularly by four papers describing five complete human genomes in 2008 al
one. One company, Knome, now even offers… more
Abstract:DESCRIPTION (provided by applicant): Heart disease frequently leads to cardiac fibrosis. In almost all cases of chronic heart disease, the myocardium exhibits fibrosis developed by activated cardiac fibroblasts. These fibroblasts are quiescent in the healthy heart. Interstitial fibrosis due to… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will assess the performance of autonomic-healing concrete asphalt through large-scale testing. Each year, about 500 million tons of hot mix asphalt is produced in America, with an average price of $80 per ton. Compared to concrete, hot… more
Abstract:DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for ast
hma, arthritis, lupus, and other chronic… more
Abstract:Aniuk Consulting, LLC, proposes to create a GIS software toolkit for easily converting NASA HDF-EOS data into formats that can be readily used within a Geographic Information System (GIS) or other geospatial software programs. The Hierarchical Data Format (HDF) is a widely used scientific data… more
Abstract:DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public heal
th and the environment. Two contaminate… more
Abstract:DESCRIPTION (provided by applicant): There is a strong need in drug discovery for cellular assays that better predict human responses to drugs. A key technical hurdle has been the difficulty of incorporating 3-dimensional extracellular matrix into a powerf
ul assay format that is compatible with the… more
Abstract:DESCRIPTION (provided by applicant): Kinases are the most intensively screened class of enzymes being targeted for therapeutic intervention because of their central role in regulating the function of other biomolecules. Strategies for developing selective
kinase inhibitors are evolving rapidly,… more
Abstract:DESCRIPTION (provided by applicant): More than 50% of drugs on the market target G protein-coupled receptors (GPCRs). Among the most important of these are drugs used to treat neurological disorders, such as pain relievers, antidepressants and anti-psychot
ics, as well drugs used for… more
Abstract:DESCRIPTION (provided by applicant): Leukocyte recruitment is central to inflammation, and there is intense focus on inhibiting the process both for chronic inflammatory disorders and for conditions where inflammation plays a contributory role, such as ath
erosclerosis. Whereas current… more
Abstract:Woody biomass is a very important feedstock for the future bioeconomy for the rural US for its availability in large quantities, ease in storage, and low cost for transportation. However, woody biomass, especially softwood, is the most difficult to convert biochemically to fermentable sugars due to… more
Abstract:We will conduct a study to explore current diagnostic imaging technologies, a search for novel technologies, or combinations of known
technologies in innovative and novel packaging that can potentially meet the sophisticated diagnostic imaging needs of the bomb technician. We will analyze novel and… more
Abstract:An innovative data collection and analysis approach is proposed to enable body mount magnetometers for space application. In order to achieve high accurate magnetic field measurement in space, the magnetometer has to be located in a fmagnetically cleanf place, where the magnetic field from… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a highly predictive model for assessing the potential of compounds to cause birth defects in the developing human embryo using human embryonic stem (hES) cells as the test substrate. The project proposes to use hES… more
Abstract:More than 52% of U.S. urban highway congestion is a direct result of highway incidents. Federal and State transportation authorities are searching for quick, cost-effective and efficient highway incident detection and warning systems. Several solutions have been proposed but none… more
Abstract:DESCRIPTION (provided by applicant): Current antifungal therapy is limited by the types of drugs available to treat systemic infections due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Crypt
ococcus and the Zygomycoses. Neutropenic… more
Abstract:The proposed study aims at accelerated development of Mo-Si-B-X (X=Ti, Zr, Hf, Re, Mn) alloys with an optimized balance of properties, via an approach of integrating thermodynamic modeling with experimental study. On the basis of the Mo-Si-B-X (X=Ti, Zr, Hf) database developed in Phase I, a… more
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