Abstract:… is one of the leading causes of morbidity and mortality worldwide. The currently available treatments are largely palliative and have minimal impact on the inflammatory proce
ss in COPD that inexorably leads to a decline in lung function. Unlike asthma, for which inhaled… more
Abstract:… by applicant): The importance of in vivo small animal research to the scientific community cannot be overestimated. Along with the advantages of small animal manipulations come inherent difficulties, among them intubations which are o
ften necessary for inhalation… more
Abstract:…. In the proposed project we will test the hypothesis that ND-AMB is a fast acting, potent and safe therapy for treating and preventing disseminated aspergillosis in mice. Because patients with pulmonary aspergillosis are less capable of taking in inhaled therapies,… more
Abstract:… bioterrorism agents as a national research priority. There is a particular need for antidotes against the toxin ricin (NIAID
, 2004); the Centers for Disease Control estimates that 500 micrograms of ricin is a lethal dose in humans exposed via injection or inhalation. Ricin,… more
Abstract:To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to develop a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed… more
Abstract:DESCRIPTION (provided by applicant): Planet Biotechnology Inc. (PBI) is developing a therapeutic recombinant protein, PBI-220, that neutralizes anthrax toxin in vitro and protects against inhalational anthrax in vivo. PBI uses transgenic plants as an innovative,… more
Abstract:… in wild- type (WT) mice. We will first develop an optimal aerosol formulation using a spray drying process, charac
terize the aerosol properties, and confirm that lead formulations can be efficiently delivered from conventional, commercially available inhalers. We will… more
Abstract:…earch are to ensure consumer and worker safety in the large and rapidly growing market for linear and compact fluorescent lamps. Lamps broken at home or during shipping release elemental mercury vapor in the immediate vicinity of adults and children. Approximately 80% of inhaled… more
f AVT particles made using this new molecule. i A. Annapragada, R. Bhavane, Agglomerated particles for aerosol drug delivery, US patent application 20030190284, October 9, 2003. ii E. Karathanasis, R. Bhavane, A. V. Annapragada, Triggered rel
ease of inhaled… more
Abstract:Inhalation airway injury is a major cause of morbidity and mortality for soldiers in modern combat. In inhalation burn victims, certain pathophysiological changes occur at a very small length scales in airway tissues immediately following exposure. Measuring these changes from… more
Abstract:…. Commercial Applications and other Benefits as described by the awardee In addition to aerosol characterization for environmental sensing applications, the Cascade Particle Detector technology should be applicable to the healthcare industry for pharmaceutical inhaler… more
Abstract:DESCRIPTION (provided by applicant): The development of anthrax countermeasures has focused almost exclusively on the perceived threat of inhalational anthrax. However, preparing a sufficiently fine powder of Bacillus anthracis spores for aerosol distribut
ion requires a high… more
Abstract:… chemical vapors/gases from an industrial or environmental accident, respiratory protection is particularly impo
rtant. The modern gas mask has a vapor tight polymer face piece that is equipped with windows and a cartridge containing activated carbon that filters the inhaled… more
Abstract:Effective methods are needed to control pervasive Lunar Dust within spacecraft and surface habitations. Once inside, airborne transmission is the primary mode of dispersion. Inhalation of this fine powder may pose a serious health risk. Lunar dust may cause degradation of… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project aims to develop a novel dry powder inhalation system, Aktiv-NebTM, for delivering antiviral drug (siRNAs) powders, to the respiratory systems of infants and young
children as an… more
Abstract:…shed its potential as a useful therap
eutic and preventative agent to assist in smoking cessation/abstinence and prophylaxis. Aktiv-Dry has developed a technology to manufacture pharmaceutically active microparticles suitable in size and stability for delivery by inhalation.… more
Abstract:…cant role in the promotion and regulation of diverse wound healing processes. NO has also been shown to have promise as an antimicrobial therapeutic and has broad range of effectiveness against human pathogens. Most current nitric oxide thera
pies (other than inhalation… more
Abstract:… nanomaterials are quantified before products with nanoscale components are widely commercialized and distributed. This project will identify factors that influence the generation, dispersion, and deposition of nanomaterials in the workplace. The risk of exposure via … more
tor system was selected because it not only provides a viable delivery vehicle, but also because of the ability of the vector to elicit an immune response. Both mouse and guinea pig animal models proposed in this study are currently being used at the UTMB
for inhalational… more
Abstract:For early inhalation injury diagnosis, currently, clinicians rely on bronchoscopy and relatively rudimentary clinical findings to make critical clinical decisions regarding prophylactic intubation and ventilator support. Assessing extent of impending airway swelling that often… more
Abstract:… annual societal cost of over 18 billion. Sadly, about 5000 Americans die every year from ast
hma, even though most asthma death is preventable with proper treatment, and the rates are especially high among the socioeconomically disadvantaged. The metered dose inhaler (MDI)… more
Abstract:The unique properties of beryllium (Be) have lead to many applications, ranging from the aerospace and nuclear industry to manufacturing and electronics. Unfortunately, beryllium is a Class A EPA carcinogen and, when inhaled into the lungs, can cause an incurable and… more
Abstract:… delivery and appropriate patient care. The display will be evaluated in both patient simulator and operating room settings. 2. We will expand the number of interaction model
s used within the PkPd Display to include other commonly used anesthetics, such as inhaled agents… more
Abstract:…n animal models and to determine whether the existing cell lines expressing mAb will be adequate to provide sufficient quantities for clinical testing. We will also inv
estigate whether a mAb can be formulated and delivered optimally as a liquid in a mouse inhalation model. … more
Abstract:… to control
insect populations in a number of agricultural and landscaping applications. Workers are exposed to these chemicals during pesticide manufacture, transport, mixing, and application. Exposure can occur via three pathways: oral, dermal, and inhalation. The… more
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