Abstract:… and lower costs offered by this technology also offer the potential of expanding the use of thermal imaging in other applications. In the firefighting market segment, equipping every firefighter with a thermal imager will reduce the number of fatalities due to smoke inhalation… more
Abstract:… and regulation of diverse wound healing processes, including burn wounds. NO has also been shown to have promise as an antimicrobial thera
peutic and has broad range of effectiveness against human pathogens. Most current nitric oxide therapies (other than inhalation… more
Abstract:… combustion of organic carbon and are found in significant amounts in automobile exhaust, cigarette smoke, various foods, an
d industrial waste by-products. They represent serious, ubiquitously environmental contaminants. PAHs contamination of individuals occurs by … more
Abstract:… Pesticides pose a significant health hazard to the general public and especially individuals working or living around farmland. Pesticides can enter the drinking water supply via run-off into lakes and streams. Pe
ople can be exposed to pesticides by inhalation,… more
Abstract:… of AMB (AmBisome), the minimal inhibitory concentration of ND-AMB against Aspergillus is 25-fold lower and in an animal model of disseminated Candidiasis, ND-AMB is effective at 5-fold lower doses. Because the normal route o
f Aspergillus infection is through inhalation of… more
Abstract:… that contain nanomaterials and the associated risk of exposure to DoD personnel is rapidly increasing. This project will identify factors that influence the generation, dispersion, and deposition of nanomaterials in the workplace. The risk of exposure via inhalation or… more
Abstract:DESCRIPTION (provided by applicant): Tularemia is the severe and sometimes fatal disease caused by infection with Francisella tularensis. These bacteria are some of the most virulent pathogens known, requiring inoculation or inhalation with as few as 10 or
ganisms to cause… more
Abstract:…. Consequently, doses are limited when treating lung cancer to an extent that it is often not effective. Drug resistance also reduces the impact of chemotherapy on the lungs. Animal studies demonstrate that anticancer drugs delivered directly to the lungs as inhaled aerosols… more
Abstract:…its potential as a useful therapeutic and preventative agent to assist in smoking cessation/abstinence and prophylaxis. Aktiv-Dry has developed a technology to manufacture pharmaceutically active microparticles suitable in size and stability for delivery by inhalation. Delivery… more
Abstract:… cGMP. 4. Examine the pharmacokinetics and toxicology of plant-produced immunoadhesin in rats and dogs. Relevance of this research to public health: Spores of Bacillus anthracis, a Class I bioterror agent, are easy to produce using unsophisticated techniques. Inhalation… more
Abstract:… treatment may be possible, based instead upon electrophysics. Dr. A. P. Krueger reports that tracheal tissues are stimulated to secrete mucus by exposure to negatively charged gaseous air ions. Dr. A. P. Wehner reports similar results for patients inhaling… more
Abstract:…ill conduct a 28 day double-blind, placebo-controlled clinical trial in 30 patients with mild to moderate asthma to assess the effectiveness of lactoferrin in relieving asthma symptoms as measured by standard parameters including FEV, asthma symptom scores and use of inhaled… more
Abstract:… successful by marginally accelerating the onset of breakthrough pain treatment relative to oral opioids. However, there remains a substantial unmet need for a faster onset treatment with minimal side effects. The goal of this proposal is to develop an inhalation device… more
Abstract:… models and measure the accuracy with which the models predict clinical responses (e.g. loss and recovery of responsiveness, vital sign responses to surgical stimuli, EEC (BIS) changes).
Phase II: We plan to incorporate additional drug models (premedicatipns, inhalation gases… more
Abstract:…ow. Development of new systems is critical in an effort to both bypass limitations of existing systems and to provide options for matching smokers to treatment. The objective of this proposal is to evaluate the feasibility of delivery of aerosolized nicotine via inhalation using… more
Abstract:… (plgR) to delivery fusion proteins consisting of a plgR-binding ligand (single chain Fv, sFv) and a protein therapeutic. The sFv (APL9) originated from a library of human VH and VL regions and is expected to be nonimunnogenic. The chimeric proteins are formulated for … more
Abstract:… by applicant): When general anesthesia is administered, anesthetics in the form of vapors are delivered to a patient in 1% to 5% concentrations. Once the surgical procedure has been completed and anesthesia is no longer administered, blood carries the inhaled anesthetic… more
Abstract:Hydrogen Sulfide (H2S)is the leading chemical agent causing human fatalities following inhalation exposures. The overall aim of this project is to develop and produce an inexpensive, highly selective and sensitive solid-state chemical micro-sensor with low power consumption… more
Abstract:… (AmBisome), the minimal inhibitory concentration (MIC) of NDAMB against Aspergillus is 25-fold lower and in an animal model of disseminated Candidiasis, ND-AMB is effective at 3 to 5-fold lower doses. Because the normal route of Aspergillus infection is through inhalation… more
Abstract:… of metals such as steel. Unfortunatey, hexavalent chromate corrosion inhibitors produce their own environmental problems, and their toxic properties are well documented. the use of chromate-inhibited spray-on coatings produce chromate containing leachates and … more
Abstract:… material has been used in shipboard environments for many years. While the material is usually safe when left undisturbed, it becomes a major health hazard during removal. The fine, needle like crystals that can be released into the air during handling are inhaled into the… more
Abstract:Concern for the potential health effects of inhaled particulates led to a federal standard governing coarse particles, or PM10, for particles below 10 ¿m and subsequently to a fine particle (PM2.5) standard in 1997, for particles below 2.5 ¿m. The U.S. Environmental… more
Abstract:… effects including growth retardation in children, osteoporosis, glaucoma and cataracts. There remains, therefore a large unmet medical need for new drugs that can more effectively and safely treat this disease. During a previous study in a sheep model of asthma, inhaled… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR proposal is the first step in the development of inhalable IgG microparticles for immunoprophylaxis against Influenza A, a category C Priority Pathogen. In Phase I, Aktiv-Dry will simultaneously stabilize, dry, and… more
Abstract:… quickly into the blood stream via injection. The utility of this form of treatment is, however, limited due to its invasiveness and the inability of many late-stage Parkinson's disease patients to self-administer injections. The aim of this project is to develop an … more
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