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Displaying 101 – 123 of 123 Awards
Company: Alexza Molecular Delivery Corporation Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: …tion affecting millions of Americans. Patients with migraine strongly desire more rapid headache relief than current medications provide. A promising approach to expediting pain relief is delivery of existing drugs to the systemic circulation more rapidly via aerosol inhalation.… more
Company: Lynntech, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2002 / 1
Abstract: …l biofilm from the surfaces of tubing within dental-unit water systems. Persons who are immunocompromised may be at risk due to some opportunistic microorganisms present in most biofilm. Contaminated water may be ingested by the patient or be aerosolized and inhaled by the… more
Company: MesoSystems Technology, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2002 / 1
Abstract: … body due to respiration. The mesochannel adsorption water-recovery device will utilize a state-of-the-art, high-capacity adsorbent to separate water vapor from the soldier'sexhaled air. The water vapor will then be desorbed into the airflow as the soldier inhales. … more
Company: RxKinetix, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: …I study demonstrates production of toxin neutralizing antibodies and lack of adverse reactions in animals, these data will be used to develop a Phase II study in which these formulations will be evaluated for their ability to elicit protection in rabbits following inhalation… more
Company: VICAL, INC. Agency/Program/Year/Phase: HHS / STTR / 2002 / 1
Abstract: … factor (LF) protects mice from an intravenous challenge using 5X the lethal dose of toxic protein. Based on this work and subsequent work (presented here) showing that a similar DNA vaccination protocol can protect rabbits from a more rigorous spore inhalation challenge,… more
Company: VOC Technologies Agency/Program/Year/Phase: HHS / SBIR / 2002 / 1
Abstract: …, ethanol, acetone, methyl acetate, and isoprene. Their concentrations range from 80 nmol/L for methane to 400 pmol/L or less for methyl acetate. More than 1000 additional compounds have been reported present in human breath, many originating in the inhaled air. Exposure… more
Company: Aerophase, Inc. Agency/Program/Year/Phase: HHS / SBIR / 2001 / 1
Abstract: DESCRIPTION (Adapted from the Investigator's Abstract): The chlorofluorocarbon (CFC) propellants currently being used in metered dose inhalers for pulmonary drug delivery are being phased out due to their high ozone depletion potential. An international… more
Company: CYTOKINETICS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2001 / 1
Abstract: … rise as reflected by increasing mortality rates. The treatment of COPD and asthma relies on long-term reduction of the chronic inflammatory response and acute symptomatic control by the use of bronchodilators. In the latter class, inhaled Beta… more
Company: Seashell Technology Agency/Program/Year/Phase: HHS / SBIR / 2001 / 1
Abstract: … when properly surface coated, can efficiently penetrate into cells, and thereby be used as therapeutic gene delivery vectors. The verification of the use of Plasmon Resonant particles for persistent labeling of impaction sites of inhaled… more
Company: INDIGO SYSTEMS CORP. Agency/Program/Year/Phase: DOD / SBIR / 1999 / 1
Abstract: … recommendations for costly procedure or hardware changes. Finally, completion of such a tool will allow, with little additional effort, a general-purpose code for the analysis of fire challenges and subsequent behavior (e.g., transport, decomposition, inhalation, and… more
Company: ARADIGM CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1998 / 2
Abstract: DESCRIPTION: (Adapted from the Applicant's Abstract). Inhaled gene products are desirable for chronic respiratory diseases with high morbidity and mortality, e.g. cystic fibrosis, emphysema, asthma, lung cancer, and tuberculosis. Aerosolization of DNA (plasmids) using… more
Company: SYNVAX Agency/Program/Year/Phase: HHS / SBIR / 1998 / 2
Abstract: … II studies will involve the synthesis of a metabocandidate peptide will be tested against different strains of type A and type B influenza viruses. Ttest the effect of the peptide on normal cellular functions. Pharmacokinetics, cell penetration, andbe conducted. An inhalation… more
Company: ARADIGM CORPORATION Agency/Program/Year/Phase: HHS / SBIR / 1997 / 1
Abstract: DESCRIPTION: (Adapted from the Applicant's Abstract). Inhaled gene products are desirable for chronic respiratory diseases with high morbidity and mortality, e.g. cystic fibrosis, emphysema, asthma, lung cancer, and tuberculosis. Aerosolization of DNA (plasmids) using… more
Company: ETALON, INC. Agency/Program/Year/Phase: HHS / SBIR / 1997 / 1
Abstract: … indeed possess dual antibronchoconstrictor/antiinflammatory activity, it could be a potentially compelling new antiasthma agent. The present application, which is a revised application, is designed to further evaluate the antiinflammatory properties of inhaled A1AS21, to… more
Company: Medtrac Technologies, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1995 / 1
Abstract: Metered dose inhalers are integral to the treatment of Asthma. Poor compliance to regimens and inapusage of pm medications has been documented in the literature as a serious problem. Data submitted tpharmaceutical companies are questionable without compliance data. Previous MDI… more
Company: SYNVAX Agency/Program/Year/Phase: HHS / SBIR / 1995 / 1
Abstract: … II studies will involve the synthesis of a metabocandidate peptide will be tested against different strains of type A and type B influenza viruses. Ttest the effect of the peptide on normal cellular functions. Pharmacokinetics, cell penetration, andbe conducted. An inhalation… more
Company: Forefront Engineering, Inc. Agency/Program/Year/Phase: HHS / SBIR / 1994 / 1
Abstract: The use of Metered Dose Inhalers (MDI) packaged medication are prevalent in the treatment oflung diseases particularly Asthma. MDI medications have inherent problems with repeatability ofapplication. Spacers and other modified packages have attempted to improve the delivery, but… more
Company: Radiation Safety Engineering, Inc. Agency/Program/Year/Phase: NRC / SBIR / 1994 / 2
Abstract: THE SOLUBILITY OF AIRBORNE RADIONUCLIDES IS AN IMPORTANT PARAMETER IN THE ASSESSMENT OF INHALATION HAZARDS IN THE WORKPLACE AND IN THE INTERPRETATION OF ROUTINE BIOASSAY DATA. SOLUBILITY IS A MAJOR FACTOR IN DETERMINING THE METABOLISM OF THE INHALED ISOTOPES AND DISSOLUTION… more
Company: Inhale Inc Agency/Program/Year/Phase: HHS / SBIR / 1992 / 1
Abstract: INHALE, INC. IS A SMALL BUSINESS DEDICATED TO THE DEVELOPMENT OF MORE PRECISE AND EFFICIENT PULMONARY DRUG DELIVERY SYSTEMS FOR THE DELIVERY OF LOCAL (LOUNG) AND SYSTEMIC THERAPEUTICS. EXISTING AEROSOL DELIVERY SYSTEMS ARE INACCURATE AND REPRODUCIBLE DOSING IS DIFFICULT TO… more
Company: Transducer Research Inc. Agency/Program/Year/Phase: USDA / SBIR / 1991 / 2
Abstract: ….S. GRAIN STANDARDS. GRAIN INSPECTION AND GRADING IS MANDATORY FOR MOST EXPORT GRAIN AND COMMON IN DOMESTIC GRAIN. THE PRESENCE OF ODOR (SOUND, MUSTY, SOUR, SMUTTY OR COFO) CAN INFLUENCE THE GRADE OF THE GRAIN. CURRENTLY, INSPECTORS PLACE THEIR FACE IN THE GRAIN AND INHALE TO… more
Company: Biocomp Systems Inc. Agency/Program/Year/Phase: HHS / SBIR / 1987 / 2
Abstract: …LY^AT LESS COST THAN RADIOISOTOPE-BASED METHODS. PHASE I IS DESIGNED TO PROVIDE TWO-DIMENSIONAL SPATIAL CALIBRATION OF THE NONTRAUMATIC RHEOENCEPHALOGRAPHIC (REG) METHOD BY COMPARING IT WITH AN ESTABLISHED RADIOLOGICAL PROCEDURE (GAMMA CAMERA WITH 133-XENON INHALATION) IN… more
Company: Technolube Products Co Agency/Program/Year/Phase: DOD / SBIR / 1987 / 2
Abstract: … PROPERTIES, E.G., GOOD DETECTABILITY BY ELECTRON CAPTURE DETECTION USING GAS CHROMATOGRAPHIC ANALYSIS, BIOLOGICAL INERTNESS, AND AN ADJUSTABLE (BY MOLECULAR DESIGN) VAPOR PRESSURE. THESE MATERIALS SHOULD ALSO POSSESS PROPERTIES OF ENHANCING ABSORPTION BY INHALATION OR… more
Company: Laguna Research Laboratory Agency/Program/Year/Phase: HHS / SBIR / 1986 / 1
Abstract: THE PROJECT IS AIMED AT THE DEVELOPMENT OF AN INEXPENSIVE, COMPACT, AND EFFICIENT GENERATOR OF THERAPEUTIC AEROSOLS SUITABLE FOR INHALATION THERAPY FOR ADULTS, INFANTS, AND CHILDREN. THE DEVICE IS EXPECTED TO PRODUCE MONODISPERSE AEROSOLS, WITH FIXED AND KNOWN DROP SIZE,… more
Displaying 101 – 123 of 123 Awards
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