Abstract:DESCRIPTION (provided by applicant): Persistent pain is the number one reason that patients access the healthcare system according to the National institutes of Health. Pain seriously affects patients' quality of life and is associated with secondary morbidities such as depression, anxiety, and… more
Abstract:DESCRIPTION (provided by applicant): This is an SBIR Phase I proposal is to test the feasibility of developing drug-like small molecules that are positive allosteric modulators of the NR2D subtype of the NMDA receptor (NR2D PAMs) for the purpose of treating impulsivity disorders, notably ADHD. The… more
Abstract:DESCRIPTION (provided by applicant): Unhealthy behaviors such as smoking, medication non-adherence, and lifestyle habits leading to obesity are major contributors to premature morbidity and mortality among the U.S. population. Participation rates in programs designed to improve these behaviors are… more
Abstract:DESCRIPTION (provided by applicant): The objective of this phase I STTR application is to continue assessment of the relevance and feasibility of Nogo decoy receptor therapy for the treatment of glaucoma. The secondary objective is to obtain pharmacokinetic data important for designing additional… more
Abstract:DESCRIPTION (provided by applicant): Cardiomyopathy is an anatomic and pathologic condition associated with muscle and electrical dysfunction of the heart, usually with inappropriate ventricular hypertrophy or dilatation. There are various causes of cardiomyopathy, many of which are genetic. Dilated… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project demonstrates the feasibility of a sketching system that bridges traditional drawing and three-dimensional modeling, offering a novel way to develop, explore and share visual ideas in 3-D. Using a fusion of hand-drawn strokes and… more
Abstract:Autism Spectrum Disorders (ASDs) are severe neurodevelopmental disabilities characterized by deficits in social and communication skills and the presence of restrictive, repetitive behaviors. For the 80 percent of individuals with ASDs who speak, prosody—the rhythm, stress, and intonation of… more
Abstract:The energetic material community has a need to produce energetic materials in varying particle sizes and morphologies. Control of particle and morphology allows the formulator to investigate various aspects of processing and performance associated with the energetic material. Unfortunately,… more
Abstract:NALAS proposes to address the challenge for novel fluorine-containing propellant components with a 3-fold approach: 1. Synthesize a fluorinated analog of BTTN as novel fluorinated plasticizer. 2. Prepare fluorinated analogs of hydroxyl-terminated polybutadiene (HTPB). 3. Prepare a novel fluorinated… more
Abstract:During Phase I of this project, NALAS endeavored to conceive a remotely operated trial nitration system that would remove the operator from harm"s way and facilitate the trial nitration process by enhancing data acquisition and enabling the creation of a data library providing guidance on… more
Abstract:BST Systems has been engaged in IR & D Projects #7079, #7103 and SBIR Phase I Topic #N101-054 targeting sealed-cell operation, separator improvement, and negative electrode enhancement. The aim is to develop a nearly maintenance-free, sealed-cell that offers overall performance improvement in… more
Abstract:ABSTRACT: The Leadership Agreement signatures on this Commercialization Readiness Program (CRP) project Small Business Innovation Research (SBIR) Technology Transition Plan (STTP 2011-51) formalize an agreement to develop the technology maturation and transition strategies, and pending funding and… more
Abstract:Use of data from multiple sensors provides the opportunity for improved ballistic missile defense search and tracking. Algorithms for combining multi-sensor data are required. Ballistic missile defense sensor data fusion is a challenging problem because of incompatibility in coordinate systems for… more
Abstract:Sonar performance predictions are often unreliable due to the lack of accurate information about the acoustic properties of the ocean around the globe. We propose to demonstrate an environmental estimation technique that uses reverberation from active sonar transmissions to infer environmental… more
Abstract:Applied Physical Sciences Corp. (APS) will develop designs and proof-of-concept devices to demonstrate a marine mammal detection capability for a variant of the AN/SSQ-125 active source sonobuoy. Acoustic transducers, signal processing algorithms, and data interfaces will be developed and tested.… more
Abstract:The Phase II effort consists of a 12-month Base and two 6-month Options. The Base is centered on the design, fabrication, and test of a prototype projector and power electronics. Testing is planned at NUWC Seneca Lake to evaluate the projector"s electro-acoustic performance. The first Option is… more
Abstract:DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States Source ADA http://www.diabetes.org/about-diabetes.jsp and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention… more
Abstract:DESCRIPTION (provided by applicant): The proposed work will result in a characterized prototype instrument that will facilitate the identification of a broad range of analytes in small volumes of human blood, urine, saliva and other readily obtainable biological fluids with little sample preparation… more
Abstract:DESCRIPTION (provided by applicant): The objective of this Phase I SBIR proposal is the development of a novel instrumentation platform based on Surface Plasmon Resonance (SPR) that if validated would greatly increase the utility of this label-free technology to researchers utilizing high-content… more
Abstract:DESCRIPTION (provided by applicant): Polymicrobial infections are of great concern to the research community because they have a dramatic impact on the productivity research groups, on the reliability of experimental results, and on the progress that can be made in unraveling fundamental biological… more
Abstract:Dried blood spot (DBS) analysis has gained recognition in recent years in basic science and clinical diagnostics. This impetus relies upon its numerous advantages over the collection, transport and storage of blood samples obtained by conventional venipuncture. Although there is wide-spread interest… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a wireless, needle implantable miniaturized (0.5 x 0.5 x 5 mm) sensor for continuous glucose monitoring, with provisions for internal self-calibration that ultimately eliminates the need for frequent, external… more
Abstract:A combined discrete cohesive interface fracture and continuum damage mechanics initiation and propagation toolkit for Abaqus will be developed for the residual strength prediction of adhesively bonded composite structures subjected to multi-axial loading. This tool will allow us, for the first time,… more
Abstract:Global Engineering and Materials, Inc. (GEM) along with its team members Northwestern University, Lockheed Martin, and Boeing Company, propose to develop an automatic software tool for 2D/3D fatigue crack growth prognosis of complicated structures under multi-axial loading. The XFAT toolkit will be… more
Abstract:A Probabilistic Fatigue Damage Assessment Network (PFDAN) toolkit for Abaqus will be developed for probabilistic life management of a laminated composite structure with both microcracking induced stiffness degradation and cyclic loading induced delamination crack growth without remeshing. It is… more
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