Abstract:DESCRIPTION (provided by applicant): Drugs used for cancer chemotherapy tend to be highly cytotoxic and genotoxic, with well-documented carcinogenic, mutagenic, and teratogenic effects. Long-term, occupational exposure to these highly toxic drugs presents
serious health risks to the healthcare… more
Abstract:This SBIR Phase I project will develop the feasibility of using piezoelectric transducers to create an artificial plant, embodied as tall bunchgrass, that will harvest and store energy from wind. This device will have aesthetic appeal and provide a nonpolluting supplement to energy produced by wind… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to demonstrate a unique and affordable method to nanotexture the surfaces of metal platform drug-eluting stents (DES) using ultrafast laser surface modification. This technology is relatively inexpensive and capable of integrating… more
Abstract:The SKATE concept was designed to quantify skill levels of trainees, teams, or units, generate skill-appropriate training scenarios, and provide a continuous skill-level assessment of disparately skilled trainees, teams, and units in a joint training exercise while maintaining the overall integrity… more
Abstract:This proposal describes an approach to realize InAs/GaSb type II superlattice focal plane arrays through planar processing. A problem with conventional mesa diode processing approaches is that nonradiative surface recombination at the exposed pn junction is extremely rapid, leading to surface… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop a compact, widely-tunable, high-brightness laser diode spectrometer that will be the core of an automated point-of-care (POC) monitor capable of tracking key blood metabolites for patients in intensive care units. The… more
Abstract:DESCRIPTION (provided by applicant): Indigenous population, travelers and troops present in Africa and South America are clearly at risk of exposure to several arenaviruses. Several human pathogenic arenaviruses, e.g., Lassa and Junin viruses, are listed o
n the NIAID's Priority Pathogens and CDC's… more
Abstract:Determining meat quality attributes in food animals is essential for genetic selection, sorting, and marketing. Ultrasound techniques have the potential to benefit the swine industry for improvements in both quality and yield measures by non-destructive and non-invasive means. Biotronics, Inc. has… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project will develop an assistive software tool for endoscopists to have real-time feedback of objective quality for colon and potential polyp region examinations. The technology is aimed to reduce polyp miss rates during colonoscopy.… more
Abstract:Energy harvesting devices utilizing magnetostrictive materials are a logical choice for harvesting the high impedance (high force, low displacement) vibrations found aboard Navy ships. Force-based devices, enabled by magnetostrictive materials, can harvest energy over an extremely large bandwidth,… more
Abstract:DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most
CF patients have a mutation that deletes… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposi
ts, and cellular debris in vessel walls,… more
Abstract:The current state of the art of soybean processing requires heat processing to eliminate anti-nutrition factors and make the protein available for digestion. The proposed research will investigate the opportunity to process a new soybean variety that has been traditionally bred (not genetically… more
Abstract:WSSV is the most serious disease in farmed marine shrimp causing considerable financial losses throughout the last decade across the globe. It infects a wide variety of crustacean hosts including numerous species of wild and cultured marine shrimp, crayfish, and prawns. Although a multitude of… more
Abstract:DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively alt
er the expression level of any desired gene… more
Abstract:DESCRIPTION (provided by applicant): Sarcopenia, defined as age related loss of muscle mass and muscle function and strength, is very prevalent among the elderly. Sarcopenia is one of the largest public health problems facing a rapidly increasing, aging po
pulation in the United States and leads to… more
Abstract:DESCRIPTION (provided by applicant): According to the American Cancer Society an estimated 182,000 cases of invasive breast cancer occurred in the US in 2008, with 40,000 deaths due to breast cancer. Among women with metastatic breast cancer, the 5-year su
rvival rate is 27%. The studies proposed in… more
Abstract:DESCRIPTION (provided by applicant): With the considerable success of our phase 2 SBIR, we have achieved the completion of lung image analysis software that segments and thoroughly measures the lungs and their five lobes along with the airway tree. We have recently just achieved 510(k) FDA… more
Abstract:DESCRIPTION (provided by applicant): The synthesis of carbohydrates remains a complex exercise that involves tremendous labor and large amounts of expensive building blocks and reagents. Even once a process for making a carbohydrate has been developed, manufacture of that molecule in all the… more
Abstract:Large scale training exercises involve many trainees at various stages of their training maturity and at various levels of skill. Problems arise in large scale exercises when less mature or lower skilled trainees are exposed to training scenarios that are too advanced or too complex for their level… more
Abstract:This proposal describes the proposed implementation of the concept of the Quality of Training Effectiveness Assessment (QTEA) system. This concept was developed in Phase I (N074-028-0065). Currently, VE design is guided by subjective design models that involve multiple design iterations and focus on… more
Abstract:Today"s Warfighter often carries an inordinate load that can lead to injuries and encumbered performance. Equipment is distributed among squad members with little, if any regard for differences in strength and anthropometry. Consequently, the current focus on human-centric design requires a… more
Abstract:DESCRIPTION (provided by applicant): If left undetected and untreated, reduced vision in one eye can lead to monocular blindness in an amblyopic eye. Most vision screening is conducted on children once they have started kindergarten; this is after the crit
ical detection period for the treatment of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop sensing technology capable of continuously monitoring concentrations of critical metabolites during protein expression with the yeast Pichia pastoris. Presently, continuous monitoring is unavailable and this process is… more
Abstract:We hypothesize that the application of the broad-spectrum immune-stimulatory and -modulatory HyperAcute alphaGal Adjuvant Technology will enhance the potency and effectiveness of VEEV vaccine candidates. To complement the exciting preclinical and clinical results obtained with alphaGal-modified… more
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