Abstract:DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by progressive and substantial loss of dopaminergic neurons in the substantia nigra compacta (SNc), resulting in severe neurological si
gns including tremors, bradykinesia, and… more
Abstract:Rotorcraft engineers traditionally use the wind tunnel to evaluate and
finalize designs. Insufficient correlation between wind tunnel results and flight tests,
have been often attributed in part to uncertainty in blockage corrections.
Estimation of rotor blockage is significantly more complex than… more
Abstract:The lack of proper estimation of air loads encountered during transient maneuvers introduces excessive design conservatism. A reduced fidelity CFD methodology based on momentum source (Rot3DC) and a comprehensive analysis code (RCAS) were coupled in Phase I to validate the ''proof-of-concept'' that… more
Abstract:Homologous recombination (HR) permits the precise insertion, deletion, or substitution of genetic material in the genome of an organism. HR offers numerous opportunities for modifying plant genomes to enhance our understanding of plant gene function and regulation, especially with respect to… more
Abstract:We propose to use physiological sensors to measure the quality of a trainee's interaction with a virtual environment (VE) as a function of VE fidelity to enable design improvements in VEs and to enhance training effectiveness through feedback of physiological-based performance information. Currently… more
Abstract:DESCRIPTION (provided by applicant): A collaborative effort between ASL Analytical, Inc. and a research team at the University of Iowa is proposed to development a noninvasive nocturnal hypoglycemic alarm. The goal for the alarm system is to provide con
tinuous noninvasive measurements during the… more
Abstract:Consumers and an ever growing segment of the pork industry know that more optimal levels of
marbling must be put back into the high-value pork cuts. Biotronics, Inc. is developing
technology to solve this problem by using real-time ultrasound to measure the percent of
intramuscular (% IMF) fat in… more
Abstract:The proposed development will result in a compact, efficient, broadband transducer module including amplifier and wet-end transducer. To facilitate multiple mission requirements, the transducer performance goals are a broad bandwidth (7-30 kHz), compact size on the order of 1/2 wavelength at the… more
Abstract:Current ASW missions require low frequency off-board sound sources that can operate monostatically or bistatically. Since these sources may or may not be recoverable, and may require a substantial number to cover the designated operating areas, the low frequency source transducers also need to be… more
Abstract:The size of conventional split ring transducers is much smaller than a wavelength at operating frequency leading to a high Q resonance and limited operating bandwidth. The proposed work will investigate two different modifications to the split ring structure that allow its resonance frequency to be… more
Abstract:"This proposal, lead by Frontline BioEnergy, teams with the Iowa State University (ISU),
Center for Sustainable Energy Technologies (CSET) to develop high quality, time-stable
and storable fast pyrolysis oils in phase-I that are useful for production of fungible liquid
fuels such as diesel, gasoline… more
Abstract:There is a clear and immediate need for improved PRRSV vaccines. PRRS is estimated to cost pork producers in the U.S. nearly $600 million annually and with a national eradication effort being proposed, the need for a second generation vaccine tool that is effective and safe is crucial. The use of a… more
Abstract:DESCRIPTION (provided by applicant): Synthetic DNA and RNA oligomers are important tools for biological and medical assays including polymerase chain reactions, sequencing, DNA microarrays, antisense technology and RNA interference. Oligomers are generally
used in experiments where they anneal to… more
Abstract:This SBIR Phase II project aims to develop and commercialize a novel, next-generation photoluminescence (PL)-based, palm-size and miniaturizable dissolved oxygen (DO) sensor. DO sensors are primary monitors of water quality in industrial wastewater treatment. The new sensor is based on a pioneering… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project aims to develop a novel chemistry to prepare metal fluorides by the direct reaction of metals with fluorocarbons. The new process is highly suited to the manufacture of: (1) wires for optical communications; (2) high-surface-area metal… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop nanolaminate Nd-Fe-B permanent magnets that will increase their operating temperatures, potentially expanding their applications in automobiles and others. An advanced yet affordable excimer laser surface modification method… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of the proposed studies is to establish the feasibility of developing therapies for brain cancers such as glioblastoma multiforme from the schweinfurthin family of antiproliferative agents. These agents
are highly toxic to CNS derived tumor cell… more
Abstract:Tripletail Ventures, Inc. aims to facilitate the creation, adoption, organization,
update, transmission, portability, and sharing of rural patient health records,
specifically for a Medicare certified dialysis unit. Many rural dialysis units in Iowa
do not have access to their patients complete… more
Abstract:DESCRIPTION (provided by applicant): The detection of small nodules is possible given the emergence of high-resolution MDCT scanning, but often accurate diagnosis is delayed because a biopsy is not easily obtained. Thus, it is not possible to make the can
cer diagnosis until rapid nodule growth is… more
Abstract:DESCRIPTION (provided by applicant): The clinical availability of volumetric high-resolution MDCT image data has increased the importance of regional assessment of pulmonary structure and function. Identification of the lung lobes is essential, not only so
that quantitative measures can be reported… more
Abstract:DESCRIPTION (provided by applicant): The goal of this SBIR Phase II proposal is to continue and expand the development of microfabricated surface patterning tools (SPTs) for the construction of ultra miniaturized biomaterial arrays (nanoarrays). SPTs can be configured as either pre-loaded molecular… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this Phase I feasibility study to design, construct and evaluate an ultraminiaturized sensor device capable of detect ng protein biomarkers from a few cells and, ultimately, single cells. The device, termed the nanobiosensor, consists of an array… more
Abstract:Over the past 15 years, the emphasis on selecting for leaner pigs with larger loineye areas and high percent lean cuts has resulted in meat with lower water-holding capacity, lower intramuscular fat (IMF), and lower scores for juiciness, flavor and overall pork quality. Swine breeders need a genetic… more
Abstract:DESCRIPTION (provided by applicant): This is a revised application. The broad, long-term objectives of this Phase I STTR proposal is to demonstrate feasibility in developing a novel optical-electronic biosensor for microscopic applications to permit simultaneous integration of photonic and… more
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