Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to demonstrate the feasibility and safety of inducing mild therapeutic hypothermia with an innovative esophageal cooling device. The use of mild therapeutic hypothermia to treat patients after resuscitation from cardiac arrest… more
Abstract:This Small Business Innovation Research Phase I project will develop computer software that automatically analyzes medical images to diagnose brain diseases affecting the elderly (such as Alzheimer's disease) that cause difficulty with memory, thinking, judgment, and other normal functions.… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will result in the development of novel ultrafast, highly selective, high permeability ion-exchange fiber composites for removing perchlorate from drinking water. The proposed technology removes perchlorate 10-100 times faster than the… more
Abstract:Volatile organic compounds (VOCs) and toxic industrial chemicals (TICs) both pose a significant threat to DoD personnel both in the field as well as in established infrastructure such as large buildings. Current VOC/TIC protection technologies suffer from incomplete removal of contaminants, high… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is developing an integrated computer vision system to objectively measures a person's gait, range of motion and balance and other mobility static and dynamic factors, targeted at fall risk in the elderly. This compact system is… more
Abstract:This Small Business Innovation Research Phase I project is aimed at the demonstration of the feasibility of pilot scale production of a novel multivalent theranostic (combination of therapeutic and diagnostic) agent, capable of controlled presentation of multiple targeting ligands by a single… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project develops a prototype gene expression platform for accurate cancer diagnosis, prognosis and treatment monitoring. Current platforms have many limitations, including slow, complex, labor-intensive processes; and suboptimal sensitivity. The… more
Abstract:This Small Business Innovation Research Phase I project aims to develop a new technology to utilize ubiquitous personal glucose meters (PGMs) for inexpensive and convenient at-home tests of the drug theophylline. Theophylline has been widely used to treat asthma and chronic obstructive pulmonary… more
Abstract:This Small Business Innovation Research (SBIR) Phase 1 project describes technologies that address the lost sense of touch inherent with touchscreens. Found on billions of products ranging from smartphones to automobiles, touch sensing technology has grown increasingly sophisticated in recent years,… more
Abstract:This proposed effort focuses on the development of a short wave infrared (SWIR) micro-camera that is capable of identifying targets at ranges of 100 to 1000 meters with a 40 degree field of view, through a collaborative effort between the proposing small business Episensors, Inc. and BAE Systems. … more
Abstract:This proposed effort focuses on the development and demonstration of an extended short wavelength infrared (eSWIR) micro-camera that is capable of identifying targets at ranges of 100 to 1000 meters with a 40 degree field of view, through a collaborative effort between the proposing small business… more
Abstract:AuraSense Therapeutics is developing oligonucleotide-modified gold nanoparticles called spherical nucleic acid (SNA) constructs, which are a powerful new way of regulating cellular gene expression. AuraSense Therapeutics will use SNAs as genetically programmable antimicrobial agents in a manner to… more
Abstract:This project will bring interferometric synthetic aperture microscopy (ISAM), a powerful new method of computed microscopy, to bear on the problem of quantitative tissue assessment. The promise of tissue engineering, including wound healing, is limited unless the tissue is treated correctly at… more
Abstract:DESCRIPTION (provided by applicant): Diagnostic Photonics, Inc. (DxP) is a medical device company developing an intraoperative imaging system for surgical guidance and real-time assessment of cancer tumor margins based on interferometric synthetic aperturemicroscopy (ISAM), a novel modality that… more
Abstract:In vivo medical imaging is becoming an indispensable tool in the screening, diagnosis, staging, treatment, and monitoring of cancer and a host of other diseases. However, the full potential of these technologies has been severely limited by image processing time and memory management of large data… more
Abstract:ABSTRACT: This proposal presents two novel approaches for the modeling of interface and interphase phenomena in composite material systems. From the computational perspective new developments include integration of Discontinuous Galerkin ideas with the variational multiscale finite element methods… more
Abstract:ABSTRACT: Acoustic monitoring is very often the most cost-effective approach for the many species that vocalize. Highly time- and cost-intensive animal monitoring tasks include field observation, search for signs of species of interest, periodic field visits to service monitoring equipment, and… more
Abstract:ABSTRACT: In an effort to improve nondestructive inspections (NDI), American Science & Technology (AST) is developing wireless capability for specific pieces of NDI equipment in the areas of eddy current and ultrasonic technologies. Traditionally, this equipment requires a cable connection… more
Abstract:This project aims at addressing and remedying the serious limitations of the three-decade old multibody system (MBS) software technology currently used in the analysis, design, virtual prototyping, and performance evaluation of modern vehicle systems. These limitations are well known and are… more
Abstract:DESCRIPTION (provided by applicant): IntelliWheels, the first automatic multi-speed transmission for wheelchairs, is a significant paradigm shift in the way that manual wheelchairs can be used because it uses automatic gear changes to facilitate propulsion. The wheelchair user still pushes the hand… more
Abstract:DESCRIPTION (provided by applicant): The project is the initial proof of concept clinical study of Civamide Nasal Spray for the treatment of postherpetic neuralgia (PHN) of the trigeminal nerve [(TN), a severely disabling facial pain syndrome]. Civamide Nasal Spray as a treatment for PHN of the [TN]… more
Abstract:Breast, cervical, and colorectal cancer can be successfully prevented and/or diagnosed and successfully treated at the earliest stages through use of appropriate and timely screening and adequate follow-up and care coordination. Recognizing the importance of cancer screening, groups like the… more
Abstract:DESCRIPTION (provided by applicant): Approximately 10 percent of hearing aid wearers have 10 dB loss of ability to understand speech in noise, in the sense that they require a signal-to-noise ratio 10 dB better than normal-hearing listeners. Since at many restaurants and social gatherings the… more
Abstract:High resolution X-ray microscopy using synchrotron radiation is a key scientific technique in materials research that has provided insight into the atomic structure of bulk materials, surfaces, interfaces, nanoparticles, nanostructures, and nanodomains. Such detailed understanding into the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a miniature gas chromatography system that can detect pollutants in homes and businesses and interface to an HVAC system for indoor air quality (IAQ) control. The device will use air as a carrier gas, and will be priced… more
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