Abstract:We plan to develop and clinically evaluate software tools for rapid and reproducible measurementof tumor-related volumes visible in 3-D medical image data. The goal is to provide better accuracy andreproducibility than existing manual and semi-manual methods of measurement, and to do so… more
Abstract:The objective is to develop a design for a broadband (5 percent or greater) millimeter wavelength high fineness ratio radome. The transmission efficiency is expected to be greater than 60 percent across the frequency band, antenna scan angles and flight (temperature) profile. Antenna pattern shift… more
Abstract:We will develop drug therapies that will successfully intervene in the course of neurodegenerat-ive diseases, with an emphasis on Alzheimer's disease (AD). One of the main reasons that efficacioustreatments for AD are unavailable is due to the lack of a model system facilitating the development… more
Abstract:The ability to display critical information within the optical train of a night vision device has become a requirement in the aviation community. The current display approaches rely on CRT's, optical combiners, lenses, and fiber optic cable to inject the symbology within the optical train of the… more
Abstract:WE PROPOSE TO DEVELOP AN ON-LINE X-RAY SYSTEM FOR DETECTING FOREIGN MATERIAL CONTAMINATION IN RAW, IN-PROCESS AND PACKAGED FOOD ITEMS. THE PROPOSED SYSTEM WOULD DETECT VERY SMALL PIECES OF METAL, GLASS, BONE, ROCK, PLASTIC AND OTHER KINDS OF FOREIGN MATERIAL CONTAMINATION IN THE FOOD PRODUCTS AT… more
Abstract:THE FEASIBILITY OF USING MINIMUM SIZED SPECIMENS FROM BROKEN HALVES OF CHARPY SPECIMENS TO FULLY CHARACTERIZE THE TRANSITION RANGE FRACTURE TOUGHNESS OF REACTOR PRRESSURE VESSEL STEELS WILL BE EVALUATED IN PHASE I. THERE ARE WELL KNOWN EFFECTS OF SPECIMEN SIZE ON MEASURED FRACTURE TOUGHNESS VALUES.… more
Abstract:Using a new, proprietary, core technology, Receptor Laboratories, Inc. (RLI) proposes to identify peptides which could be used directly as injectable drugs to thwart the toxic effects of ricin poisoning and consequently eliminate it as a military threat. This technology has the potential to… more
Abstract:A conceptual remote power technology which converts the energy emitted from safe radioisotopes to electrical energy which can be used to produce hydrogen with photoelectrochemical conversion without intermediate thermalization of the high-grade ion energy has been developed. The potential efficiency… more
Abstract:THE HARSH RADIATION ENVIRONMENT PRESENTED BY THE D-T BURNING PLASMA IN NEXT-STEP TOKAMAK FUSION DEVICES CAN CAUSE SEVERE DAMAGE TO CRITICAL OPTICAL COMPONENTS USED IN RESEARCH DIAGNOSTICS AND CONTROL INSTRUMENTATION. THE TECHNICAL OBJECTIVE OF PHASE I IS TO DETERMINE THE FEASIBILITY OF USING… more
Abstract:Cubane C8H8 is potentially an extremely valuable fuel substitute for the kerosene-based rocket propellant RP-1. The classical Eaton synthesis to yield cubane 1,4-dicarboxylic acid in five steps involves a key photochemical reaction. The steps before and after the critical 2+2 cycloaddition are… more
Abstract:The hapten molecule CF3(CH3)P(OR)3 which mimics the transition state for hydrolysis of organophosphates such as soman will be synthesized. A protein conjugate will be used for monoclonal catalytic antibody production. A key element of the hapten is that it is a phosphorane (pentacoordinate… more
Abstract:SYSTEMS & ELECTRONICS, INC. (SEI) IS PROPOSING A PROGRAM OF RESEARCH AND DEVELOPMENT TO MANUFACTURE, TEST, INSTALL AND EXPERIMENT WITH AN EFFICIENT, LIGHTWEIGHT, LOW-COST, RELIABLE AIRFRAME CUMULATIVE FATIGUE RECORDING DEVICE THAT CAN EFFECTIVELY BE USED IN MEASURING AIRCRAFT USAGE. THE PROPOSED… more
Abstract:The proposed innovation is a two-actuator, singularity-free double pointing system which has a spherical geometry. It has potentially widespread application as the basis of a new generation of singularity-free manipulator wrists which will not generate coupled arm/wrist singularities. It will also… more
Abstract:The goal is to develop a knowledge-based expert management system to deliver cost-effective quality medical care. This system will allow health care providers to plan and allocate services within the existing budgeting and economic constraints. The methodology consists of 1) building an integrated… more
Abstract:Development of novel boronated compounds and use of epithermal neutrons has now generated much interest in 10B-boron capture neutron therapy of different tumors. However, no suitable methods exist that allow investigation of their pharmacokinetics in human subjects or in vivo measurement of the… more
Abstract:THE RESULT OF THIS PHASE I EFFORT WILL BE A DETAILED PLAN TO SIGNIFICANTLY INCREASE THE SPEED AND, HENCE, THE INTERACTIVITY OF ANALYZE, AN ALREADY USEFUL MEDICAL IMAGE ANALYSIS SYSTEM. ANALYZE IS A SOFTWARE SYSTEM FOR THE ANALYSIS OF MEDICAL IMAGES, DEVELOPED AT MAYO FOUNDATION'S BIOTECHNOLOGY… more
Abstract:X-ray computed tomography (CT) is widely used in defense, aerospace, and industrial applications. CT provides flaw detection, density measurement, accurate dimensions, morphology, assembly verification, material property analysis, and other vauable information. However, a major limitation of CT has… more
Abstract:We propose to develop in this Phase I SBIR a technique to produce high-energy, multi-aspect radiographic images in near real-time, using a conventional real time radiography (RTR) system. This technique, stereo-pair imaging, will allow three-dimensional analysis of RTR images by producing two views,… more
Abstract:We will develop a new construction method for receiver coils for magnetic resonance imaging (MRI) of the human breast. These coils will be custom-shaped to individual patients in a quick, economical, and comfortable manner. Since each structure fits the individual patient closely, the coil system… more
Abstract:Laser chemical vapor deposition (LCVD) silicon nitride fiber growth is proposed, to make fibers which have the strength and oxidative stability required for advanced high temperature structural applications. This method has been demonstrated to yield continuous, high strength fibers of materials… more
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