Abstract:Linoleic acid, the predominant polyunsaturated fatty acid (PUFA) in the human diet, can bemetabolized by cyclooxgenase, lipoxygenase and P450 enzymes. The monohydroxy derivatives oflinoleic acid, 9(S)-HODE and 13 (S)-HODE, are the most widely distributed of the known linoleic acidmetabolites. These… more
Abstract:The development of cancer is a complex process that appears to involve multiple mechanisms.Recent studies indicate that the Her-2/neu (ERBB2) gene may be important in the transformation ofnormal breast epithelial cells to a cancerous phenotype. In reality, more than one-half of breast cancersare… more
Abstract:A novel class of postaglandin F2-like compounds formed in vitro or in vivo by a free-radical catalyzed noncyclocxygenase mechanism have recently been discovered. For normal humans. Levels of these compounds (called F2-isoprostanes) range from 5-50 pg/ml plasma and 500-3000 pg/ml urinary creatinine,… more
Abstract:We will develop and market a comprehensive collection of antibodies specific for enzymes that play a significant role in drug metabolism . Availability of specific antibodies will greatly facilitate studies of polymorphisms, species and tissue distribution of drug metabolizing enzymes, and the role… more
Abstract:We are proposing a fundamental leap forwards in both technique and performance of measurement techniques for characterizing ultrahigh-speed electronic signals. We will design and build a laser-based oscilloscope for characterizing electrical signals in the picosecond time regime. The oscilloscope… more
Abstract:COATED REFRACTORY-METAL MEMBRANES ARE SUGGESTED FOR HYDROGEN EXTRACTION FROM GAS MIXTURES FOR HYDROGEN PURIFICATION, FOR PRODUCING REFORMULATED GASOLINE AND FOR MEMBRANE-REACTOR USE. PALLADIUM-BASED MEMBRANES HAVE BEEN USED FOR DECADES FOR HYDROGEN PURIFICATION AND MEMBRANE REACTORS BECAUSE… more
Abstract:AT PRESENT THERE IS NO SAFE, CHEAP AND EFFECTIVE COMMERCIAL METHOD TO ENHANCE FERTILITY IN FARM ANIMALS. PREVIOUS WORK AT MICHIGAN STATE UNIVERSITY HAS SHOWN THAT IMMUNONEUTRALIZATION OF INHIBIN (A GONADAL GLYCOPROTEIN THAT SUPPRESSES SECRETION OF FOLLICLE STIMULATING HORMONE) ENHANCES: OVULATION… more
Abstract:Advances in signal processing and high speed digital image processing electronics make it feasible to implement a real-time image reconstruction algorithm in a digital FLIR system. Implementation of such an algorithm would result in increased spatial resolution on the order of two to three times and… more
Abstract:Digital communications networks require hard wired electrical connections to link multiple nodes in a network. Wired connections tether a system and inhibit the relocation of network nodes in a cost effective manner. Additionally, there is an increasing need for protable wireless digital… more
Abstract:Industrial and remediation activities requiring emissions control generate tons of contaminated adsorbents each year. A process is proposed that destroys organics either on an adsorption bed in-situ or in a secondary reactor at mild conditions (170-250 degrees C). The process internally heats the… more
Abstract:Immobility and impractical input devices used in existing Computerized Charting Systems (CCS)cause disruption of established work processes and thus discourage widespread clinical acceptance.A novel design based on hand-held computers which recognize handwriting is presented. An electronicstylus… more
Abstract:Recent developments in catalyst technology have led to new routes for the preparation of high surface area (HSA) early transition metal nitrides. These materials have physical and chemical properties which make them interesting candidates for use as electrodes in high energy density electrolytic… more
Abstract:Inflammatory bowel disease (IBD) is a collective term that includes Crohn's disease andulcerative colitis. Although both disorders have a distinct clinical course with characteristicpathophysiology, the destructive and progressive course of IBD probably is due to persistent elevatedexpression of… more
Abstract:THE RESEARCH CONCERNS THE PROSPECTS FOR ENRICHING SPATIAL PERCEPTION IN THE BLIND VIA A DIGITAL, VIDEO BASED CAMERA WHOSE PROJECTED VISUAL IMAGES TRANSFORMATIONS ARE TRANSDUCED INTO ANALOGOUS TACTILE TRANSFORMATIONS ON A NEWLY DEVELOPED ELECTROTACTILE ARRAY. SINCE DYNAMIC PATTERNS OF ELECTROTACTILE… more
Abstract:This proposed effort is to evaluate the various Multichip Module technologies available in term of technology maturity and ability to manufacture large scale production quantities with a supply base that will allow the military ground vehicle manufacturers and automobile industry to include this… more
Abstract:Hematopoiesis, the regulated production of mature blood cells, is a complex scheme of multilineage differentiation which occurs mainly in the bone marrow of adult mammals. Mature cells are continuously produced from progenitor (or precursor) cells. Consequently, assays which detect these progenitor… more
Abstract:NAVIGATION OF FIELD MOBILE ROBOTIC SYSTEMS REQUIRES A MEANS FOR THE ROBOTIC SYSTEM TO DETERMINE ITS ABSOLUTE LOCATION. THE USUSAL MEANS IS TO USE A VEHICLE INTERTIAL GUIDANCE SYSTEM WHICH IS PERIODICALLY UPDATED BY A GPS OR LORAN C RECEIVER. UNFORTUNATELY, GPS AND LORAN CAN ONLY PROVIDE ABSOLUTE… more
Abstract:MOBILE ROBOT SYSTEM NAVIGATION IS A DIFFICULT PROBLEM UNDER ANY CIRCUMSTANCES. OUTSIDE NAVIGATION USING COMPUTER VISION-BASED METHODS REQUIRES RECOGNITION OF VARIABLE TERRAIN FEATURES OR THE USE OF A RADIO LOCATION SYSTEM SUCH AS A GLOBAL POSITIONING SYSTEM. INDOOR NAVIGATION IS TYPICALLY… more
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