Abstract:DESCRIPTION (provided by applicant): This proposed Phase II Renewal is aimed at finalizing the research and development of a new and greatly improved long term extracorporeal membrane oxygenator (ECMO) for patients afflicted with severe respiratory and/orcardiac failure. Results from Phase II work… more
Abstract:Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes usually above 18,000ft, often without visual cues (clouds, etc.), making it difficult to avoid. The vortices produced when atmospheric waves "break" can… more
Abstract:Clear air turbulence (CAT), often referred to as "air pockets," is attributed to Kelvin-Helmholtz instabilities at altitudes generally above 18,000ft, often in the absence of any visual cues such as clouds, making it difficult to avoid. The vortices produced when atmospheric waves… more
Abstract:As wind turbine rotor diameters increase in size, especially for offshore wind farms, susceptibility to damaging wind conditions is increasing as well. The fatigue and extreme loads that a turbine must endure ends up increasing the Cost of Energy (CoE) significantly through higher maintenance and… more
Abstract:The design of an aircraft is a highly iterative process. During the conceptual design phase there is no time for developing detailed simulation models and decisions are typically made either by using low fidelity models or existing data and regression models. However, the decisions made during the… more
Abstract:The DOE Systems Biology Knowledgebase (Kbase) was envisioned to provide a framework to support modeling of dynamic cellular processes of microorganisms, plants and metacommunities. The Kbase will provide the tools and data to permit rapid iteration of experiments that draw on a variety of data types… more
Abstract:DESCRIPTION (provided by applicant): The objective of this application is to develop advanced optrode solutions for neuroscientists that fulfill the potential of optogenetic technology-achieving highly specific neural circuit control. Once developed, the neuroscientist's experimental options… more
Abstract:DESCRIPTION (provided by applicant): Deep Brain Stimulation (DBS) devices - 'brain pacemakers' - have emerged as a revolutionary new approach to the treatment of neurological disorders. DBS therapy uses controllable electrical stimulation delivered to specific deep brain structures through… more
Abstract:The main goal of this proposal is to develop novel lightweight high strength composite materials to be used as materials for next-generation transparent armor for multifunctional structural load support and mitigation of ballistic threats and blast impacts. While providing adequate protection most… more
Abstract:Superhydrophobic nanostructured coating will be developed from transparent ultrastrong materials. The coatings will be scalable, inexpensive, mechanically robust and thermally resilient. We will initially design such coatings using layered nanocomposites. Then it will be optimized for different… more
Abstract:Superconducting radio frequency (SRF) accelerating cavities are being successfully used for acceleration of electron beams worldwide. The use of superconducting structures helps maximize the accelerating gradient, which is a highly desirable trait for applications involving linear accelerators or… more
Abstract:in accelerators for light sources, first as passive cavities for stabilizing the beam and later in the accelerating sections. In this SBIR proposal, Niowave and Brookhaven National Lab will collaborate to adapt the quarter wave cavity geometry for use as an accelerating structure for light sources.… more
Abstract:The highest priority in the Nuclear Physics program is, at present, the Facility for Rare Isotope Beams. In the longer term it is likely that a high priority will be an Electron Ion Collider, and several concepts are under development. In order to achieve the high luminosities that would be required… more
Abstract:Recent advances in superconducting electron linacs have decreased the size and complexity of these systems such that they can be economically competitive with copper linacs and proton accelerators for a broad range of applications. Niowave is developing compact turn-key superconducting electron… more
Abstract:DESCRIPTION (provided by applicant): Me, A Doc is a serious medical diagnosis role-playing simulator program in a video game interface that aims to improve high school and college student learning about the biology of disease in a way that fosters critical thinking and reduces the achievement gap… more
Abstract:This Small Business Innovation Research Phase II project proposes to develop an imaging based monitoring system for the piercing process used in the manufacturing of seamless steel tubes based on the feasibility proven in Phase I. Piercing is the core process of the near net-shape manufacturing… more
Abstract:Fixed and rotary winged aircraft require directed infrared counter-measures (DIRCM) systems to self-protect against heat seeking missiles, and the DIRCM multi-spectral light source is a key enabling technology and differentiator. Omni Sciences, Inc. (OSI), has developed a Mid-Infrared… more
Abstract:ABSTRACT: Opteos Inc. is proposing a new approach to the measurement of electric fields based on the electrooptics principles. This system promises an extremely high bandwidth of operation, 50GHz to 100GHz, a wide dynamic range up to 60dB, and high accuracy better than 1% full scale. The system is… more
Abstract:DESCRIPTION (provided by applicant): Metabolism of administered drugs is determined by expression and activity of drug-metabolizing enzymes, such as cytochrome (CYP) P450 enzymes. These P450s are subject to inhibition and sometimes induction by xenobiotics, leading to possible pharmacokinetic… more
Abstract:DESCRIPTION (provided by applicant): Current biomarkers employed in the detection of organ toxicity are often not sensitive enough to detect the early stages of acute organ damage, i.e. at a stage when reducing or eliminating exposure to a toxin could prevent progression of organ damage or a disease… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to develop Poloxamer-188 (P-188) for the delay or prevention of respiratory deficits in patients with Duchenne muscular dystrophy (DMD). Phrixus Pharmaceuticals Inc. is also developing P-188 for the treatment of acute… more
Abstract:In this Phase II project, we propose to develop, construct, and deliver to NASA a prototype single-sided computed tomography time-domain terahertz (single-sided CT TD-THz) scanner accessory. This accessory will be suitable to be mounted onto a non-destructive evaluation (NDE) imaging gantry for the… more
Abstract:Picometrix's time-domain terahertz (TD-THz) non-destructive evaluation (NDE) technology could be usedto inspect space flight structures such as inflatable space habitats, thermal protection systems (TUFI-typetiles, SOFI TPS), for voids, disbonds, and damage such as tearing and micron-meteorite… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop software for an accurate simulation of polymer co-extrusion. During co-extrusion, different polymers are extruded simultaneously through a single die. Coextruded plastic parts combine the functionalities and benefits of… more
Abstract:The Massachusetts Institute of Technology and Quantum Signal LLC propose to research and develop the TerrAdapt system for terrain classification and vehicle driving control. This work will result in fundamental research advances, but will be practical enough for application on today"s COTS… more
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