Abstract:IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY (IMAC) HAS SUBTANTIAL UTILITY AS A PROTEIN PURIFICATION TOOL FOR BOTH ANALYTICAL AND PREPARATIVE APPLICATIONS. THERE IS A STRONG MARKET NEED FOR AN IMAC SUPPORT SUITABLE FOR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC). RESEARCHERS ARE DEVELOPING AN HPLC… more
Abstract:This proposal addresses the need to develop products which will help participants in health care assquality and level of care furnished to patients. We will develop a prototype ¿Protocol Engine¿, withdesigned for personal computers and computer networks, to allow protocols to be defined and… more
Abstract:Disability is the nation's largest public health issue; with over 35 million Americans experiencing disability and annual disability-related costs exceeding $170 billion. Planning for the efficient and equitable allocations of state and local rehabilitation services has generally been inadequate,… more
Abstract:The innovation presented in this proposal involves the use of a liquid melt thermal spray process for cost effective rapid prototyping of near-net shape tooling for the lay up of advanced composite materials. The process uses a focused beam of charged liquid droplets to form tooling directly from… more
Abstract:A Phase I SBIR program is proposed to develop crystalline materials for optical limiters. Crystals will be fabricated into micro-balls and suspended in an index matched glass for use in practical applications. The materials development portion of the program will involve studies of the use… more
Abstract:A Phase I research program is proposed with two primary technical objectives that are critical to the development of real optical memory devices based on solid state materials. The first objective will be to characterize striae in optical memory materials and subsequently grow improved… more
Abstract:The information produced by the Human Genome Project and related research is expected torevolutionize biology and medicine in general and recombinant DNA technology in particular. At present,however, obtaining patent protection for inventions involving recombinant DNA technology is anacknowledged… more
Abstract:SEED ROT CAUSED BY THE FUNGUS PYTHIUM ULTIMUM IS A MAJOR CAUSE OF CROP LOSS IN NORTHERN CLIMATES WHERE COOL PLANTING SEASONS ARE COMMON. SEEDS ARE GENERALLY TREATED WITH THE FUNGICIDES METALAXYL AND CAPTAN (BANNED IN GERMANY) TO PREVENT SEED ROT. A BIOTYPE OF THE BACTERIA PSEUDOMONAS AUREOFACIENS --… more
Abstract:Enzymes used as the label for most non-radioactive assays and in biosensors, are the most unstable component of these systems. As immunoassays and biosensors move from the tightly controlled laboratory environment to demanding field conditions, the need for a more stable enzyme becomes critical.… more
Abstract:A program is proposed to develop a commerical source for spectral hole burning materials and their properties. The proposed program will create a file of material and their properties for this application. A crystal growth program is proposed to grow Eu:Y2Si05, Pr:YA103, and Sm:CaW04.
Abstract:Several laser designers have requested Scientific Materials Corporation (SM) to consider methods to achieve a cladding for Tm:YAG diode pumped laser rods. SM has looked at several mechanical methods and concluded mechanical systems are impractical. In the early 1960's the PI of this program… more
Abstract:COAL-FIRED MAGNETOHYDRODYAMIC (MHD) TECHNOLOGY HAS ADVANCED TO THE STAGE OF TESTING LARGE SCALECOMPONENTS TO DEMONSTRATE THE FEASIBILITY OF THE OVERALL PROCESS FORAPPLICATION AS A VIABLE COMMERCIAL POWER GENERATION TECHNIQUE. HOWEVER, TESTING TO EVALUATETHE FUNDAMENTAL ASPECTS OF ELECTRODE WEAR IS… more
Abstract:1Four different strains of white-rot fungi including P. chrysosporium, will be tested to determine their effectiveness in degrading TNT, RDX, and HMX. Bacteria has not been effective in cleaving the ring structure resulting in incomplete degradation. The ability of white-rot fungi to degrade ring… more
Abstract:AGRICULTURAL ENGINEERS AND SCIENTISTS HAVE EXPRESSED A NEED FOR A TRULY PORTABLE FLOW MEASUREMENT SYSTEM THAT RELIES ON SIMPLE PHYSICAL PRINCIPLES. THE SYSTEM SHOULD INCLUDE INEXPENSIVE AND RELIABLE SENSORS CAPABLE OF INTERFACING WITH ELECTRONIC EQUIPMENT. THIS RESEARCH WILL INVESTIGATE THE… more
Abstract:As cancer treatments improve, the view that the illness is "chronic" rather than "terminal" isbecoming widespread. Under this new paradigm, caregivers have an increasing obligation to helppatients and their families learn how to live with the illness. While attention is given to "quality of life"as… more
Abstract:Many military installations and Department of Defense (DoD) contractors are subject to recently promulgated regulations that require storm water flow metering and collection of both grab samples (in response to a rainfall event of a specified intensity) and flow-weighted composite samples. Such… more
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