Abstract:DESCRIPTION (provided by applicant): This STTR application is to develop and test for eventual clinical use a new strategy for tumor specific anticancer drug delivery. The technology, Clostridia-directed enzyme prodrug therapy, or CDEPT, exploits the factthat certain non-pathogenic bacteria of the… more
Abstract:The environmental impacts of coal bed methane development (CBM) in Montana and the Rocky Mountain States are well documented. CBM exploration is expanding rapidly with the nation's focus on energy independence and the relative ease of extraction. Extraction of CBM necessitates pumping large volumes… more
Abstract:In this NASA Phase I STTR effort, the feasibility of fabricating isolated ridge waveguides in 5% magnesium-doped lithium niobate (5% MgO:LN) will be established. Ridge waveguides in MgO:LN will significantly improve the power handling and conversion efficiency, increase photonic component… more
Abstract:This SBIR Phase I effort will establish the feasibility of fabricating advanced waveguide structures in potassium titanyl phosphate (KTP) capable of efficiently generating 25 to 40 mW of frequency converted light in the 395 to 480 nm. The key innovation in this effort is to utilize KTP waveguides in… more
Abstract:This SBIR Phase I effort proposes to establish the feasibility of developing a compact, high performance laser source for integration into the next generation seed laser system for high stability, multi-wavelength lidar applications such as NASA Langley's HSRL program. Combination of the high… more
Abstract:This Small Business Innovation Research Phase I project will develop a compact, rugged, rapidly and widely tunable laser based on a quantum cascade diode laser at mid-infrared wavelengths. The key innovation in this effort is the use of an engineered electro-optic tuning element in an external… more
Abstract:This NIST Phase II SBIR effort will two low noise single photon detectors using MgO doped LiNbO3 (LN) periodically poled waveguides and a 980nm (or similar appropriate wavelength) pump to up convert 1550nm photons to 600nm to allow for detection by photomultiplier tube (PMT). The key innovation is… more
Abstract:Army quantum information researchers have an immediate need for improved stable, narrowband violet and UV laser sources with 10-100 mW output and 10 MHz-10 GHz tuning. These sources are required for numerous ion and atom qubits functions including photoionization, Doppler cooling, state… more
Abstract:Beekeeping is a billion dollar industry, of which honey production plays only a small part. Most beekeepers make their money with crop pollination, charging up to $120 per hive for this service. Crop growers want healthy, strong colonies. It takes a skilled beekeeper about 10 minutes to inspect a… more
Abstract:In 2007, the U.S. Supreme Court ruled that carbon dioxide (CO2) is a pollutant under the federal Clean Air Act. The ruling allows the EPA to regulate CO2 emissions. Such regulation will entail monitoring a wide variety of pollution sources including automobile exhaust systems, industrial emission… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project addresses an urgent law enforcement need for a sensitive, portable, low-cost, laser remote sensor to detect illicit methamphetamine (meth) production labs from a distance. The research objectives are to: 1. Refine, optimize, and package… more
Abstract:This Small Business Innovative Research Phase I research project will demonstrate the feasibility of a high-precision optical metrology system that meets a current market need for extremely precise distance measurements with rapid update rates. The project will actively stabilize newly developed… more
Abstract:Bridger Photonics proposes to prove the feasibility of an innovative method for multi-mode target identification. To achieve this system, the team will combine the most advanced ultra-high-resolution FM-CW LADAR unit in existence with state-of-the-art feature-specific computational imaging concepts… more
Abstract:This Phase II proposal addresses the need for an innovative, affordable spray-on material system that mitigates low frequency acoustic radiation through a ship hull induced by airborne noise in shipboard compartments containing various electro-mechanical systems. The Phase I project objectives were… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project involves the development and characterization of a new type of active anticorrosion coating with zero VOC, zero HAP, and zero heavy metal content… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop and demonstrate a prototype Hypoxia Perfusion Bioreactor (HPB). In order to utilize recent discoveries that low oxygen levels are favorable to stem ce
ll expansion, Resodyn Corporation has… more
Abstract:Besides temperature, pH measurement is one of the most common controls used in the processing of aqueous media within various industries. One example is in chemical processing where titration is often used to drive the pH to a certain level, in order to initiate, maintain, optimize, or terminate… more
Abstract:The reliability of wind turbine systems is greatly impacted by hidden defects. Therefore, an improved method of inspection is sought for the manufactured composite materials used in these systems. In addition, an inspection method is also needed in the field, to assure quality during and after… more
Abstract:Current mixing and casting procedures result in unwanted gradients in solid rocket motor (SRM) material properties with subsequent ballistic property variations. Resodyn Corporations-Y ResonantAcoustic? mixing (RAM) technology is poised to revolutionize the design, development and production of… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop and demonstrate a commercial prototype of a ResonantAcoustic(R) Biological Shaker (RBS). ResonantAcoustics(R) is a low-frequency acoustic mixing techn
ology that is non-invasive and highly… more
Abstract:DESCRIPTION (provided by applicant): Antibiotic resistant pathogens, such as methicillin-resistant Staphylococcus aureus, are a significant public health problem which is compounded by the slow rate of development of new antibiotics. Investigators at Merck
Research Laboratories recently reported on… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I STTR project is to identify novel negative allosteric modulators of the nicotinic acetylcholine receptor. This project seeks to partner the drug discovery technology of the Promiliad Biopharma w
ith the expertise of Professor Dennis McKay… more
Abstract:We aim to design and demonstrate an innovative photonic true time delay solution which alleviates the fundamental problem of cascaded optical switches, and additionally offers several significant benefits. The device uses wideband spatial-spectral (S2) holographic optical memory materials to store… more
Abstract:The objectives of the base project are three-fold: 1) An existing prototype hardware spectrum analyzer receiver system will be enhanced, tested in house, and ruggedized to enable it to be field tested at a federal test site (in the option). Work will focus on dynamic range improvements, continuous… more
Abstract:We propose to analyze and design prototype hardware, and demonstrate basic capabilities in a Phase I effort, based on coherent accumulation and interference of spectrally shaped waveforms to achieve wideband RF arbitrary waveform generation. The combined specifications include bandwidths of 10-40… more
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