Abstract:DESCRIPTION (provided by applicant): An estimated 116 million US adults suffer from chronic pain at an estimated cost of 635 billion and, unfortunately, existing pain management training is not adequately preparing health professionals to address this area . Opioid prescription drugs, obtained… more
Abstract:DESCRIPTION (provided by applicant): An estimated 116 million US adults suffer from chronic pain at an estimated cost of 635 billion and, unfortunately, existing pain management training is not adequately preparing health professionals to address this area . To address this gap we propose to… more
Abstract:DESCRIPTION (provided by applicant): Our overall goal is to market a COG compound (aka. apoE-mimetic peptides) for the treatment of patients with asthma. Cognosci has discovered, patented and published a novel series of COG compounds which are functionalmimetics of apolipoprotein-E. These COG… more
Abstract:ABSTRACT: The US Air Force (AF) is increasingly being required to conduct operations in complex environments with friendly forces or noncombatants in relatively close proximity to targets. Currently there is no single weapon which can offer a satisfactory range of lethal effects on the variety of… more
Abstract:Corvid Technologies is pleased to offer a solution for remotely delivering explosive detection materials. The objective is to deliver a liquid explosive detection agent with a 40mm projectile using existing launch systems. Innovative materials and design techniques will be used to ensure accurate… more
Abstract:Corvid Technologies is excited to offer a unique solution for protecting tactical vehicles during high-speed external transport. The innovative design employs a fabric net structure rigged to the vehicle which significantly reduces the impeding air velocity on critical components. This approach… more
Abstract:The primary objective of this effort is to further develop and validate a computational capability which can be used to assess propulsion systems for compliance with insensitive munitions (IM) requirements. Comprehensive testing to ascertain IM compliance for such systems is time consuming and… more
Abstract:Corvid Technologies is pleased to offer this SBIR Phase II proposal. In the proposed effort, we will extend the high-fidelity analysis processes demonstrated during Phase I to generate large-scale, production-quality databases for intercept debris fragments. Our approach utilizes an innovative… more
Abstract:DESCRIPTION (provided by applicant): The treatment of injuries or diseases affecting articular or elastic cartilage poses important unmet challenges to the medical community. The goal of this Phase I SBIR is to further the development of a method for themanufacture of a biologically-derived… more
Abstract:DESCRIPTION (provided by applicant): Angiogenesis and hypoxia can significantly influence the efficacy of therapy and the behavior of surviving tumor cells. This important fact is supported by a vast amount of literature on pre-clinical models and clinical studies. There is growing demand for… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will address new regulations being enacted in the shipping industry requiring Sulfur Oxides (SOx) reduction from engine emissions. Many commercial scrubber systems effectively remove SOx from engine emissions, yet none are designed to… more
Abstract:DESCRIPTION (provided by applicant): It is currently estimated that 15% of the world's population is undernourished and 5 million childhood deaths a year are attributable to malnutrition. The ability to feed the world in the future will be even more difficult due to population growth, climate… more
Abstract:DESCRIPTION (provided by applicant): Liver toxicity is a major barrier to the FDA approval of many new drugs. Moreover, since the liver is the major site of metabolism of most xenobiotics it is essential to know how the liver metabolizes new drug. Becauseof the many species differences between… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop an operating-room-ready system for needle guidance in soft tissue, which fuses intra- operative ultrasound and pre-operative X-ray computed tomography (CT) data by combining two novel technologies:1) a radically different way of visualizing… more
Abstract:DESCRIPTION (provided by applicant): Dental caries is one of the most prevalent diseases in the U.S. with 85% of adults and the majority of children having been treated for at least one incidence. While this disease impacts all individuals, it is especially an issue for those of low economic status… more
Abstract:This Small Business Innovation Research Phase I project describes a cost-effective method for reducing the quantities of copper used for agricultural crop protection. Currently, millions of pounds of copper are being sprayed onto plants each year. This copper is released into the environment,… more
Abstract:DESCRIPTION (provided by applicant): One-third of costs associated with hospital acquired infections (HAIs) are attributed to surgical site infections (SSIs), and SSIs result in a two-fold increase in patient mortality rates. SSIs are most often caused byflora from the patients skin that enter the… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a devastating and costly mental illness with direct and unemployment costs approaching 95 billion per year. Cognitive impairments affect the majority of patients with schizophrenia. These impairments are strongly associated with poor long-term… more
Abstract:DESCRIPTION (provided by applicant): Consumption of unhealthy media messages that normalize or glorify risky sex is related to early and risky sexual behaviors in adolescents. Critical analysis of these media messages promotes healthy perspective-taking about relationships and sexual behaviors. The… more
Abstract:This Small Business Innovation Research Phase I project addresses a novel metrology sensor to enable advanced multi-dimensional measurements of high aspect ratio structures. The current proposed work focuses on a novel methodology using nanoneedles to create a new nano-metrology sensor and extend… more
Abstract:DESCRIPTION (provided by applicant): Current assays employed to assess the potential of drugs and environmental agents for their potential to cause birth defects involve the use of animal models. Not only are these models costly and time consuming, but they also have poor concordance to human data.… more
Abstract:We plan to implement a planar Molecularly Controlled Semiconductor Resistor (MOCSER) gas sensor on both InAs and InN platforms for the ppt-ppm detection of NOx and H2O. Kyma Technologies and Duke University will leverage Duke"s leading MOCSER based NOx sensor technology which uses surface… more
Abstract:Aluminum Gallium Nitride (AlGaN) has broad dual use applications for power transistors, high frequency transistors, high power Schottky barrier diodes, and solar-blind detectors, as well as ultra-violet laser diodes and ultra-violet light emitting diodes. This unique material system spans the… more
Abstract:The overall objective of this program is to improve the producibility of HVPE GaN through the use of in-situ monitoring during the growth process. Various in-situ monitoring devices will be used: a UV absorption technique to monitor the GaCl concentration above the growing GaN wafer; a commercial… more
Abstract:In this proposal, we build on demonstrated expertise in Bulk GaN growth (Kyma Technologies), High Indium Mole Fraction InGaN and quaternary AlInGaN growth (NCSU- Salah Bedair), device fabrication and characterization (NCSU- John Muth), Optical Photopumping (ARMDEC- Henry Everitt) and expertise in… more
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