Abstract:DESCRIPTION (provided by applicant): Universal newborn hearing screening is mandated in the US and is performed in the postpartum hospital setting. Current physiology-based hearing screening tests are unable to detect late-onset hearing loss caused by cytomegalovirus (CMV) infection. Therefore, a… more
Abstract:DESCRIPTION: Lead toxicity is a serious but preventable public health problem in the U.S. and elsewhere in the world. Even at very low levels, ingested lead causes irreversible damage, especially in young children, resulting in decreased IQ, learning disabilities, attention deficit disorders,… more
Abstract:DESCRIPTION (provided by applicant): In 2010, more than 12 million people reported using prescription pain medications (opioids) non-medically (without a prescription) , and 2 million people reported using prescription painkillers non-medically for thefirst time . In 2009, 1/3 o people older… more
Abstract:DESCRIPTION: (provided by applicant) An epidemic of addiction to prescription pain medications now causes deaths due to overdose that outnumber automobile-related deaths, rising admissions to hospitals, and disrupted lives for both the patient and family.The White House Office of National Drug… more
Abstract:DESCRIPTION (provided by applicant): An estimated 116 million US adults suffer from chronic pain at an estimated cost of 635 billion and, unfortunately, existing pain management training is not adequately preparing health professionals to address this area . To address this gap we propose to… more
Abstract:Project Goal/Intended Impact: To improve outcomes of in-treatment addicted patients by providing a virtual reality game as part of a regular health care visit with a health care provider. The game can be played with an off- the- shelf commercially available gaming system that can sense and be… more
Abstract:DESCRIPTION (provided by applicant): Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for Alzheimer's Disease: A Therapeutic Based upon Apolipoprotein-E That is Not Targeted to Amyloid-Beta Background on Alzheimer's Disease: Alzheimer'sDisease (AD) is the leading… more
Abstract:DESCRIPTION (provided by applicant): Diabetic peripheral neuropathy (DPN) is one of the most common and devastating complications of diabetes mellitus, affecting more than 50% of diabetic patients, and is the leading cause of foot amputation. DPN, characterized by peripheral axonal degeneration and… more
Abstract:Corvid Technologies is pleased to offer this SBIR Phase I proposal. In the proposed effort, we will develop a fast-running, predictive methodology for the aerothermal demise of the debris generated during a Ballistic Missile Defense intercept event. This model will be informed by existing… more
Abstract:In a Phase I effort, Corvid Technologies will develop and test candidates for a series of advanced ballistic shields for crew served weapons stations intended to replace heavy, cumbersome shielding that does not meet required specifications. Current armor production efforts by Corvid will be… more
Abstract:On today"s battlefields, vehicles are at risk of encountering improvised explosive devices (IEDs). Fortunately, not all of these result in complete vehicle loss. Sending a vehicle back to the depot for overhaul when it could have stayed in operation, wastes precious resources. Conversely,… more
Abstract:As MDA continues implementation of the Phased Adaptive Approach (PAA), high fidelity and accurate characterization of post-intercept debris environments will become more and more critical to the successful operation of the larger Ballistic Missile Defense (BMD) system. The objective of this… more
Abstract:Corvid Technologies is pleased to offer this STTR Phase I proposal in collaboration with The Johns Hopkins University Applied Physics Laboratory and Spectral Sciences, Incorporated. The emphasis of the proposed effort is to develop a new methodology for predicting late-time EO/IR signatures from… more
Abstract:Corvid Technologies in collaboration with Dynetics, Inc ("Dynetics") is pleased to present the following proposal to the Missile Defense Agency (MDA) SBIR solicitation MDA12-028 entitled Improved Target Discrimination of Multiple Targets Using Bulk Filtering for Debris. This proposal will… more
Abstract:As MDA continues implementation of the Phased Adaptive Approach (PAA), robust operation of BMDS sensors within post-intercept debris environments will become more critical to successful operation of the larger BMDS. Due to a paucity of test data, development and performance testing of BMDS sensors… more
Abstract:The objective of the proposed Phase II program is to leverage existing first-principle physics-based codes and improve our ability to predict lethality outcomes for hypervelocity missile intercepts using our Velodyne code. In particular, we will address deficiencies in our high explosive (HE)… more
Abstract:Corvid Technologies is pleased to offer comprehensive computational analysis, experimental testing, and design of an advanced warhead. The objective is to design a warhead capable of overpressure defeat of point detonating fuses in rocket, artillery, and mortar (RAM) targets. A successful Phase I… more
Abstract:Corvid Technologies is excited to offer a unique solution for protecting tactical vehicles during high-speed external transport. The innovative design employs a fabric net structure rigged to the vehicle which significantly reduces the impeding air velocity on critical components. This approach… more
Abstract:DESCRIPTION (provided by applicant): Standard microfracture is a first-line, widely used and cost-effective surgical technique for repairing damaged articular cartilage, but, it is limited by decreased long-term efficacy and limited applicability in largerlesions. This leads to a burgeoning economic… more
Abstract:DESCRIPTION (provided by applicant): Controlling mechanical signal transduction to treat osteoarthritis Abstract The TRPV4 calcium (Ca++) permeable ion channel has been shown to be expressed and functional in chondrocytes, the cells responsible for the maintenance of cartilage in weight-bearing… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this study is to develop a tissue-engineered total joint replacement from an engineered biomaterial scaffold combined with adult bone marrow-derived mesenchymal stem cells (MSCs) for regeneration ofthe entire femoral surface of the hip joint.… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase I effort is determine the feasibility of developing a unique antimicrobial catheter to reduce the instances of the most prevalent healthcare associated infection, Catheter-Associated Urinary TractInfection (CAUTI). This research and… more
Abstract:Sorghum is a major crop for food, feed and industrial processes in the US and on the global market. It is a particularly relevant crop under the current pressures of climate change and food security because it is adapted to cultivation under low water and nutrient conditions. However, compared to… more
Abstract:DESCRIPTION (provided by applicant): Medical drugs and devices are regulated by the U.S. Food and Drug Administration (FDA) based on data from multicenter clinical trials. In 2010, U.S. spending on clinical trials was approximately 25 billion. Over the past decade the efficiency of clinical trials… more
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