Abstract:This Phase 1 SBIR project aims to develop a frequency stabilized laser diode system suitable for application in optical metrology and in displacement measurement. The compact design of the semiconductor laser lends itself to many applications where a coherent light source is required, but space is… more
Abstract:Currently nuclear-based gauges are the most widely used equipment in the construction industry to measure moisture and density of pavement materials. Such measurements are very accurate, rapid, and non-destructive. Attempts to replace these nuclear methods by non-nuclear methods have shown strong… more
Abstract:The objective of proposed work is to demonstrate the feasibility of obtaining AlGaN films of any composition with dislocation densities below 1x106 cm-2 on native nitride substrates either by sustaining a pseudomorphic state or by reducing the number of threading dislocations by specific stress… more
Abstract:During the parachute deployment, cotton"buffer"fabrics are employed to prevent friction/abrasion damage to the nylon fabrics as they rub against each other at high speeds. Due to procurement difficulties and several technical deficiencies, the Army would like to replace the… more
Abstract:The use of automated robotic tooling is required in a number of space missions. It is possible to have better tool control if the robotic arm could report loads experienced by the tooling.ATI Industrial Automation proposes to develop and prove technologies to be used in a low weight, low outgassing… more
Abstract:DESCRIPTION (provided by applicant): The counterfeit drug business originated with lifestyle drugs, such as the erectile dysfunction drug. Now, however, counterfeits in almost any therapeutic category may be purchased by Americans through internet pharmacies. In fact, the Pharmaceutical Safety… more
Abstract:DESCRIPTION (provided by applicant): Cachexia-anorexia syndrome is a life-threatening aspect to many diseases, in particular many forms of cancer or therapies for cancer. The obvious symptoms of this disease include lack of appetite, and a loss of lean body mass disproportionate to the reduction in… more
Abstract:Innovation in perishable foodstuff track-and-trace is of critical importance to cost and time-sensitive customers such as the food industry where spoilage is of concern, safety and security are paramount, and counterfeit and bio-terrorism prevention are urgent priorities. The proposed research would… more
Abstract:This Phase I project develops and evaluates a mobile application for teaching elementary and middle school aged children with intellectual and developmental disabilities toilet training skills. A team of educational experts, technology experts, and parent of a child with autism collaborate on the… more
Abstract:The US is rapidly losing small-to-medium scale farmers. In the 10 years between 2007 and 1997, the U.S. lost over 11,000 farms and over 32 million acres of farmland. To save and attract new farmers to agriculture requires that farming be a profitable enterprise and that farmers have access to… more
Abstract:Fungi are microorganisms which are found throughout the world and are responsible for many natural processes including the decomposition of plant material and subsequent release of carbon, the preparation of food and beverages, as the source of pharmaceuticals, as well as the cause of a variety of… more
Abstract:DESCRIPTION (provided by applicant): Recently, temozolomide (TMZ), a myelosuppressive alkylating chemotherapy, has shown a benefit in patients with glioblastoma multiformes (GBM), but median survival is still less than 15 months. Moreover, these conventional chemotherapies lack specificity and… more
Abstract:DESCRIPTION (provided by applicant): Chronic Myelogenous Leukemia (CML) affects nearly 14,000 patients worldwide and is a disorder of the pluripotent hematopoietic stem cells with two distinct phases. The protracted myelopoliferative chronic phase is followed by a rapidly fatal blast crisis. In CML… more
Abstract:DESCRIPTION (provided by applicant): The mu-opioid receptor (MOR) is the primary target for opioid analgesics. While opioids are the most frequently used and effective analgesics for the treatment of moderate to severe clinical pain, their prolonged use leads to reduced efficacy and a number of… more
Abstract:DESCRIPTION (provided by applicant): CT has become a routine medical tool in diagnosis of diseases and visualization of critical interventional procedures. The number of CT examinations has significantly increased over the past two decades in the US, and reached approximately 72 million in 2007… more
Abstract:DESCRIPTION (provided by applicant): Glaucoma is one of the leading causes of blindness in the world affecting 67 million people. Reduction of intraocular pressure (IOP) is the only proven treatment for delaying the progression of vision loss caused by glaucoma. The current surgical options for IOP… more
Abstract:DESCRIPTION (provided by applicant): Epilepsy is a set of disorders that result from neuronal hyperexcitability and hypersynchronous neuronal firing. Epilepsy remains a major widespread neurological concern. Current medications do not meet the health needsof 30% of epilepsy patients, and… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project will investigate an ultra-wideband tunable radio frequency filter for use as a universal channel selection filter to maximize spectrum utilization. The research during Phase I will focus on high fidelity modeling of a tunable phase… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to develop a proof of principle prototype of an agile solar concentrator which would be deployable in a wide range of applications and environments. The innovation will produce a fabric module that would lead to development of a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is for the development of a full-page, portable, low cost, refreshable Braille display based on the state-of-the-art electroactive PVdF polymer technology. The full-page Braille display is a very useful device which will promote Braille… more
Abstract:ABSTRACT: The primary objective of this research effort is to develop a next-generation time-gated ballistic imaging (BI) system for three-dimensional characterization of liquid breakup within dense fuel sprays. The temporal resolution will be varied using nonlinear time gating and pulse shaping… more
Abstract:ABSTRACT: A new knowledge-based approach is proposed to mitigate the corrosion of metallic surfaces. The approach is based on the rational design of molecular coating materials based on a new class of phthalocyanines. While these materials resemble fluorinated polymers in their capacity to… more
Abstract:Camber Ridge proposes to build a modular tire testing apparatus to overcome the shortcomings of conventional tire testing machines. The apparatus involves an instrumented spindle mounted on a tire orientation manipulation device which can dynamically position the tire in any orientation necessary… more
Abstract:DESCRIPTION (provided by applicant): Acute Myeloid Leukemia (AML) accounts for a high percentage of all adult leukemia cases. Although most patients at first respond well to conventional chemotherapy, there is a high rate of relapse and patients become refractory to front-line treatment, which bears… more
Abstract:DESCRIPTION (provided by applicant): Congestive heart failure is a major cause of morbidity and mortality in the United States. While progress in conventional treatments is making steady and incremental gains to reduce heart failure mortality, there is a critical need to explore new therapeutic… more
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