Abstract:DESCRIPTION (provided by applicant): Dry Eye disease is an affliction that impacts as many much as 20% of the U.S. population over age 50, and is even more prevalent in the Asia Pacific. Dry eye therapies are currently a 1.7B market, growing at 10% annually. Treatment is primary palliative,… more
Abstract:DESCRIPTION (provided by applicant): The dire implications of the adult obesity epidemic grow worse over time. Despite front page coverage and universal agreement that the epidemic in weight gain and secondary disease establishment must be addressed, the problem continues. Intended Impact: We… more
Abstract:DESCRIPTION (provided by applicant): Step2 CS Training in Alcohol Addiction and the Medical Consequences of Alcohol This project will create a website, WebOSCE.com, to provide a unique training opportunity for medical students to: 1) prepare for the USMLE(R) Step 2 CS (Clinical Skills) examination,… more
Abstract:DESCRIPTION (provided by applicant): An estimated 116 million US adults suffer from chronic pain at an estimated cost of 635 billion and, unfortunately, existing pain management training is not adequately preparing health professionals to address this area . Opioid prescription drugs, obtained… more
Abstract:DESCRIPTION (provided by applicant): An estimated 116 million US adults suffer from chronic pain at an estimated cost of 635 billion and, unfortunately, existing pain management training is not adequately preparing health professionals to address this area . To address this gap we propose to… more
Abstract:Project Goal/Intended Impact: To improve outcomes of in-treatment addicted patients by providing a virtual reality game as part of a regular health care visit with a health care provider. The game can be played with an off-the-shelf commercially available gaming system (Microsoft Xbox Kinect)… more
Abstract:DESCRIPTION (provided by applicant): Our overall goal is to market a COG compound (aka. apoE-mimetic peptides) for the treatment of patients with asthma. Cognosci has discovered, patented and published a novel series of COG compounds which are functionalmimetics of apolipoprotein-E. These COG… more
Abstract:ABSTRACT: The US Air Force (AF) is increasingly being required to conduct operations in complex environments with friendly forces or noncombatants in relatively close proximity to targets. Currently there is no single weapon which can offer a satisfactory range of lethal effects on the variety of… more
Abstract:Corvid Technologies is pleased to offer a solution for remotely delivering explosive detection materials. The objective is to deliver a liquid explosive detection agent with a 40mm projectile using existing launch systems. Innovative materials and design techniques will be used to ensure accurate… more
Abstract:Corvid Technologies is excited to offer a unique solution for protecting tactical vehicles during high-speed external transport. The innovative design employs a fabric net structure rigged to the vehicle which significantly reduces the impeding air velocity on critical components. This approach… more
Abstract:The primary objective of this effort is to further develop and validate a computational capability which can be used to assess propulsion systems for compliance with insensitive munitions (IM) requirements. Comprehensive testing to ascertain IM compliance for such systems is time consuming and… more
Abstract:Corvid Technologies is pleased to offer this SBIR Phase II proposal. In the proposed effort, we will extend the high-fidelity analysis processes demonstrated during Phase I to generate large-scale, production-quality databases for intercept debris fragments. Our approach utilizes an innovative… more
Abstract:DESCRIPTION (provided by applicant): The treatment of injuries or diseases affecting articular or elastic cartilage poses important unmet challenges to the medical community. The goal of this Phase I SBIR is to further the development of a method for themanufacture of a biologically-derived… more
Abstract:DESCRIPTION (provided by applicant): Angiogenesis and hypoxia can significantly influence the efficacy of therapy and the behavior of surviving tumor cells. This important fact is supported by a vast amount of literature on pre-clinical models and clinical studies. There is growing demand for… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will address new regulations being enacted in the shipping industry requiring Sulfur Oxides (SOx) reduction from engine emissions. Many commercial scrubber systems effectively remove SOx from engine emissions, yet none are designed to… more
Abstract:DESCRIPTION (provided by applicant): It is currently estimated that 15% of the world's population is undernourished and 5 million childhood deaths a year are attributable to malnutrition. The ability to feed the world in the future will be even more difficult due to population growth, climate… more
Abstract:DESCRIPTION (provided by applicant): Liver toxicity is a major barrier to the FDA approval of many new drugs. Moreover, since the liver is the major site of metabolism of most xenobiotics it is essential to know how the liver metabolizes new drug. Becauseof the many species differences between… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop an operating-room-ready system for needle guidance in soft tissue, which fuses intra- operative ultrasound and pre-operative X-ray computed tomography (CT) data by combining two novel technologies:1) a radically different way of visualizing… more
Abstract:DESCRIPTION (provided by applicant): Dental caries is one of the most prevalent diseases in the U.S. with 85% of adults and the majority of children having been treated for at least one incidence. While this disease impacts all individuals, it is especially an issue for those of low economic status… more
Abstract:This Small Business Innovation Research Phase I project describes a cost-effective method for reducing the quantities of copper used for agricultural crop protection. Currently, millions of pounds of copper are being sprayed onto plants each year. This copper is released into the environment,… more
Abstract:DESCRIPTION (provided by applicant): One-third of costs associated with hospital acquired infections (HAIs) are attributed to surgical site infections (SSIs), and SSIs result in a two-fold increase in patient mortality rates. SSIs are most often caused byflora from the patients skin that enter the… more
Abstract:A biologic nanoparticle is the basis of this proposal. The plant virus nanoparticle (PVN) is based on a virus that: exists in the human food chain; is nontoxic and of low immunogenicity; can load medical imaging agents and/or therapeutic drugs into itscargo chamber by a simple process; and can be… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a devastating and costly mental illness with direct and unemployment costs approaching 95 billion per year. Cognitive impairments affect the majority of patients with schizophrenia. These impairments are strongly associated with poor long-term… more
Abstract:DESCRIPTION (provided by applicant): Consumption of unhealthy media messages that normalize or glorify risky sex is related to early and risky sexual behaviors in adolescents. Critical analysis of these media messages promotes healthy perspective-taking about relationships and sexual behaviors. The… more
Abstract:The overall objective of this project is to develop a web-based media literacy substance use preventive intervention for use with parents and their elementary school children, called Media Detective Family (MDF), designed to overcome barriers to preventionefforts in rural communities. MDF provides… more
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