Abstract:DESCRIPTION (provided by applicant): Liver toxicity is a major barrier to the FDA approval of many new drugs. Moreover, since the liver is the major site of metabolism of most xenobiotics it is essential to know how the liver metabolizes new drug. Becauseof the many species differences between… more
Abstract:DESCRIPTION (provided by applicant): We propose to develop an operating-room-ready system for needle guidance in soft tissue, which fuses intra- operative ultrasound and pre-operative X-ray computed tomography (CT) data by combining two novel technologies:1) a radically different way of visualizing… more
Abstract:DESCRIPTION (provided by applicant): Dental caries is one of the most prevalent diseases in the U.S. with 85% of adults and the majority of children having been treated for at least one incidence. While this disease impacts all individuals, it is especially an issue for those of low economic status… more
Abstract:This Small Business Innovation Research Phase I project describes a cost-effective method for reducing the quantities of copper used for agricultural crop protection. Currently, millions of pounds of copper are being sprayed onto plants each year. This copper is released into the environment,… more
Abstract:DESCRIPTION (provided by applicant): One-third of costs associated with hospital acquired infections (HAIs) are attributed to surgical site infections (SSIs), and SSIs result in a two-fold increase in patient mortality rates. SSIs are most often caused byflora from the patients skin that enter the… more
Abstract:A biologic nanoparticle is the basis of this proposal. The plant virus nanoparticle (PVN) is based on a virus that: exists in the human food chain; is nontoxic and of low immunogenicity; can load medical imaging agents and/or therapeutic drugs into itscargo chamber by a simple process; and can be… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a devastating and costly mental illness with direct and unemployment costs approaching 95 billion per year. Cognitive impairments affect the majority of patients with schizophrenia. These impairments are strongly associated with poor long-term… more
Abstract:DESCRIPTION (provided by applicant): Consumption of unhealthy media messages that normalize or glorify risky sex is related to early and risky sexual behaviors in adolescents. Critical analysis of these media messages promotes healthy perspective-taking about relationships and sexual behaviors. The… more
Abstract:The overall objective of this project is to develop a web-based media literacy substance use preventive intervention for use with parents and their elementary school children, called Media Detective Family (MDF), designed to overcome barriers to preventionefforts in rural communities. MDF provides… more
Abstract:This Small Business Innovation Research Phase I project addresses a novel metrology sensor to enable advanced multi-dimensional measurements of high aspect ratio structures. The current proposed work focuses on a novel methodology using nanoneedles to create a new nano-metrology sensor and extend… more
Abstract:DESCRIPTION (provided by applicant): Current assays employed to assess the potential of drugs and environmental agents for their potential to cause birth defects involve the use of animal models. Not only are these models costly and time consuming, but they also have poor concordance to human data.… more
Abstract:We plan to implement a planar Molecularly Controlled Semiconductor Resistor (MOCSER) gas sensor on both InAs and InN platforms for the ppt-ppm detection of NOx and H2O. Kyma Technologies and Duke University will leverage Duke"s leading MOCSER based NOx sensor technology which uses surface… more
Abstract:Aluminum Gallium Nitride (AlGaN) has broad dual use applications for power transistors, high frequency transistors, high power Schottky barrier diodes, and solar-blind detectors, as well as ultra-violet laser diodes and ultra-violet light emitting diodes. This unique material system spans the… more
Abstract:The overall objective of this program is to improve the producibility of HVPE GaN through the use of in-situ monitoring during the growth process. Various in-situ monitoring devices will be used: a UV absorption technique to monitor the GaCl concentration above the growing GaN wafer; a commercial… more
Abstract:In this proposal, we build on demonstrated expertise in Bulk GaN growth (Kyma Technologies), High Indium Mole Fraction InGaN and quaternary AlInGaN growth (NCSU- Salah Bedair), device fabrication and characterization (NCSU- John Muth), Optical Photopumping (ARMDEC- Henry Everitt) and expertise in… more
Abstract:In this proposal, we build on demonstrated expertise in Bulk GaN growth (Kyma Technologies), Design and simulation of Power Devices and systems (NextWatt LLC), Epitaxial Growth of High Performance HEMT heterostructures (Virginia Commonwealth University), and Fabrication of Advanced Semiconductor… more
Abstract:Gallium nitride (GaN) substrates are a critical component in the roadmap of power efficient and high frequency electronic devices in the coming years. One major hurdle of this technology is the limited availability of large diameter, high quality substrates for large scale device fabrication. Under… more
Abstract:This Small Business Innovation Research Phase II project will develop long fiber thermoplastic (LFT) compositions based on recycled carbon fiber. In Phase I, we demonstrated the ability to make high quality LFT formulations based on (1) waste carbon fiber and (2) composites scrap and end-of-life… more
Abstract:This project will develop a low-cost tooling system for prepreg composite molding capable of processing epoxy-and BMI- matrix composites at temperatures of 400F (205C). Such a tooling system would be applicable to advanced airframe components including both military applications and commercial… more
Abstract:There is a need for a simple, portable, quantitative method to monitor the presence of Harmful Algal Blooms. Electrochemical detection offers some advantages for analysis, but traditional sensors are not practical for routine field use. Adapting colorimetric immunoassays on porous, flow-through… more
Abstract:ABSTRACT: In this Phase I Air Force SBIR program, NanoTechLabs (NTL)will develop a space-qualifiable, high-conductance, thermal interface material (TIM) for use in space-based flanged heat-pipe-to-heat-pipe joints or for mounting relatively small area units with stiff baseplates and high power… more
Abstract:In this Phase I effort, NanoTechLabs will develop a family of related products/techniques for improving the performance of carbon fiber structural composites by introducing small amounts of carbon nanotubes into structurally critical areas. These new carbon nanotube structural products will be… more
Abstract:The future capabilities of sensors and instrumentation deployed in space will continue to increase, resulting in increasing amounts of collected data. To reach these higher speed data rates, increases to the overall system gain of the communication link will be required. A deterministic method to… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop the process and engineering controls necessary to scale up the manufacturing of a nitric-oxide-releasing active pharmaceutical ingredient (API). One of the applications is a wound-healing product for diabetic foot ulcers… more
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