Abstract:USE OF NUCLEOSIDE PHOSPHATES AS ANTITUMOR AND ANTIVIRAL AGENTS HAS BEEN LIMITED BY THEIR INABILITY TO PENETRATE CELL MEMBRANES AS WELL AS THEIR HIGH SUSCEPTIBILITY TO ENZYMES SUCH AS PHOSPHATASES, NUCLEOTIDASES, ETC. MODIFICATION OF THE PHOSPHATE GROUP (BY REPLACING ONE OF THE NONBRIDGING OXYGENS… more
Abstract:NEUTRON CAPTURE THERAPY IS A VERY PROMISING THERAPY FOR CERTAIN TUMORS, SUCH AS GLIOMAS AND MELANOMAS. SEVERAL NUCLEI HAVE HIGH CROSS SECTIONS FOR THERMAL NEUTRONS, OF WHICH BORON-10 ((10)B) AND GADOLINIUM-157 ((157)GD) HAVE BEEN SHOWN TO BE VERY PROMISING. (10)B HAS A HIGH CROSS SECTION FOR THERMAL… more
Abstract:The main objective of the research is to develop a new class of topoisomerase II (Topo II) inhibitors as antineoplastic agents. In preliminary studies, heterocyclic amine-carboxyboranes have been shown to possess cytotoxic activity against a number of murine and human tumor tissue culture lines, e.… more
Abstract:We will design and synthesize novel nucleic acid base derivatives containing cyanoborane group attached to a pyridine-type nitrogen atom of the purine or the pyrimidine cycle. The cyanoboronated bases may be designed to be more membrane soluble than the respective 2'- deoxyribonucleosides of known… more
Abstract:A major problem with the use of nucleoside phosphates as antiviral and antitumor drugs has been their inability to penetrate cell membranes. Additionally, nucleoside phosphates are susceptible to phosphatases and nucleases, which reduce their in vivo life time. Replacement of the charged phosphate… more
Abstract:A new approach to signal detection and classification is applied to the problem of ASW and torpedo defense for shallow-water environments. The approach is particularly appropriate for applications where the statistics of the signal and the noise are unknown and highly variable. The primary goal is a… more
Abstract:There is an increasing need in many military systems to have solid state microwave devices with higher power capability, higher reliability, and higher operating temperatures. These devices would be important for airborne radar systems, electronic warfare and countermeasure systems, and airborne and… more
Abstract:Silicon carbide possesses a unique combination of properties, not available from other more common semiconductors, which allow it to operate in certain severe environments. These properties include a wide bandgap, a high melting point, high breakdown electric field, and high thermal conductivity, as… more
Abstract:BETA-SIC HAS BEEN KNOWN FOR MANY YEARS TO HAVE EXCELLENT THEORETICAL PROPERTIES FOR THE PRODUCTION OF HIGH POWER MICROWAVE DEVICES. THE COMBINATION OF ITS WIDE BANDGAP (2.2 EV @ 27 DEGREES CENTIGRADE), HIGH SATURATED ELECTRON DRIFT VELOCITY (2.5x10(7) CM/SEC), HIGH BREAKDOWN ELECTRIC FIELD (4x10(6)… more
Abstract:This program will demonstrate the applicability of the freeze crystallization (FC) process dirctly to U.S. Air Force environmental managers by, in phase I, (1) finding applications that are well served by this technology, (2) demonstrating the capabilities of the FC process by processing wastes in… more
Abstract:When loading nitrogen tetroxide before launching the space shuttle, fugitive N2O4 is absorbed into caustic solutions in a two stage scrubber solution. The second stage of the scrubber has sodium sulfite added to the alkaline scrubbing solution to act as an oxidant scavenger, to improve scrubbing… more
Abstract:THE PROVISION OF ACCEPTABLE LEVELS OF OCCUPANT COMFORT IN AN ELECTRIC VEHICLE (EV) ADDS CONSIDERABLY TO THE LOAD ON THE BATTERY SYSTEM. BATTERIES BARELY STORE ENOUGH ENERGY TO PROVIDE AN ADEQUATE RANGE WITHOUT ANY AUXILIARY LOAD. THE ADDITION OF MAJOR POWER-CONSUMING OPTIONS, SUCH AS AIR… more
Abstract:The intent is to create an artificial intelligence software system which accurately predicts chemical toxicity. The system will use a neural network to recognize patterns and correlation between chemical structure/substructures, physicochemical properties, and toxicologic/carcinogenic findings. An… more
Abstract:Increasing evidence suggests that chemically-induced cell proliferation plays a role in carcinogenesis. The complex relationships between chemically-induced mutations, cytotoxicity, cell proliferation and carcinogenesis are important considerations in setting doses for cancer bioassays, classifying… more
Abstract:This proposal is for the development of an optically activated high voltage semiconductor switch device capable of switching loads on and off within nanoseconds or picoseconds. A device of this type would not be possible using the existing limitations imposed by the limited knowledge on the… more
Abstract:THE PROPERTIES OF CLOSED OR ALMOST-CLOSED SURFACES WITH BETA-EMITTING WALLS WILL BE STUDIED BY MEANS OF POWERFUL MONTE CARLO TRANSPORT MODELS. POSSIBLE USE OF THE ENCLOSURES IN DELIVERING AREALLY UNIFORM SURFACE DOSES TO TARGETS THAT ARE EITHER WITHIN THE ENCLOSURES OR THAT ARE EXTERNALLY APPOSED TO… more
Abstract:We propose research into the design of a Real-Time Distributed Module Interconnection Framework (RTD-MIF) system for use in the development of distributed, real-time computer software. Real-Time capabilities will include abnormal event processing, RT/FT events and on-line system monitoring and… more
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