Abstract:DESCRIPTION (provided by applicant): The goal of this project is to create a system to conduct 'High Throughput Multifunction System for Neurophysiology of Behavior', in response to PA-08-001. The advanced system will provide capabilities for many other Behavioral Neurophysiology research… more
Abstract:DESCRIPTION (provided by applicant): This Phase I pilot is to assess the feasibility of using the Family Health Network's Connected for Life Program as an intervention to increase access to web-based technologies and as a tool to support independent living. The relationship between declining… more
Abstract:DESCRIPTION (provided by applicant): The CDC reports that over 40 million Americans suffer from chronic disease, the majority of whom report multiple diagnoses of chronic disorders. The causes of many of these chronic diseases are not well understood and doctors struggle to effectively diagnose and… more
Abstract:DESCRIPTION (provided by applicant): The purpose of this project is to research and develop digital media-based nutrition education materials for low science literacy, underserved, and minority patients receiving dialysis treatment for ESRD. The developedmaterials will lay the foundation and serve… more
Abstract:DESCRIPTION (provided by applicant): The first isolated human hepatoctyte 2D culture, in 1981, provided baseline protocols to support freshly isolated and immediately cultured populations. With cryopreservation technology, human hepatocytes are commercially-available on demand, however, about 75% of… more
Abstract:DESCRIPTION (provided by applicant): ABSTRACT Interruption and subsequent restoration of circulation in tissues causes varying amounts of ischemia- reperfusion injury (IRI). IRI is a detrimental feature of many clinical events such as organ transplants, cardiopulmonary bypass (CPB) used in… more
Abstract:DESCRIPTION (provided by applicant): Over the last decade, the National Institutes of Health (NIH) has funded on average about 15,000 biomedical science trainees per year at various stages in their careers, with 2009 financial data showing a total of 790million spent on research training. Data from… more
Abstract:DESCRIPTION (provided by applicant): Studies of patient triage in selected populations found significant numbers of patients needing either a more or a less acute level of care, and that 47%-58% of ED visits were considered inappropriate by triage nurses and physicians. Contributing to this problem… more
Abstract:DESCRIPTION (provided by applicant): By the end of 2006, an estimated 23,000 adults and 15,500 children had received cochlear implants in the United States alone (www.nidcd.nih.gov). The complexity of the system as well as confounding factors such as brainplasticity and changing physiology require… more
Abstract:Gemcitabine (Gemzar) is an effective chemotherapeutic drug approved for treatment of several cancers, including non-small cell lung cancer (NSCLC), pancreatic, breast and ovarian cancer. However, its use has been limited due to its short half-life and significant systemic toxicity. This proposal… more
Abstract:ABSTRACT: Avolare 2, LLC proposes the simulation and quantization of single event effects (SEUs) on highly scaled (i.e., sub-65 nm gate length) metal source/drain"Schottky"CMOS (SB-CMOS) transistors. Mixed-mode 2D device/circuit simulations of an SRAM core (back-to-back inverters)… more
Abstract:using its proprietary patent pending Power Controllers BVSI will operate a micro grid that will 1) increase the efficiency of electrical motors, 2) integrate renewable energy sources and power storage options seamlessly, and reduce fuel consumption by ~50%.
Abstract:Sustainable biofuel solutions that produce drop-in diesel and jet fuels compatible with existing petroleum-based infrastructure are critical to reducing the environmental impact of petroleum fuels and protecting US energy independence. Fungal systems can address this problem through the production… more
Abstract:DESCRIPTION (provided by applicant): With funding from NIMH, TeleSage has developed a state-of-the-art mental health outcomes tracking survey instrument for use with both public- and private-sector adults. This survey is currently in statewide use in Tenne
ssee and Iowa. Unfortunately, no… more
Abstract:DESCRIPTION (provided by applicant): Computer Adaptive Testing (CAT) provides a new mechanism for assessing patient-reported outcomes. Using CAT can: (a) increase measurement precision, leading to a decrease in the number of participants necessary to achieve statistically significant… more
Abstract:DESCRIPTION (provided by applicant): The economic burden of diabetes on patients and their families is considerable. According to the most recent estimate in 2007, the yearly cost of diabetes was approximately 174 billion. Landmark studies have demonstrat
ed that improved metabolic control of… more
Abstract:DESCRIPTION (provided by applicant): Laser Biopsy Inc, (LBI) has a vision of improving the speed and quality of cancer diagnosis with reduced patient risk and reduced cost. LBI is developing a new medical imaging system that will enable pathologists to per
form real-time diagnosis of biopsies taken… more
Abstract:The majority of personnel injured in OIF/OEF have suffered blast effects from IEDs. Blasts often cause cranio-facial trauma that is difficult to repair. There is a significant need to develop better platform technologies for these injuries and translate them into clinical and commercial use. A… more
Abstract:DESCRIPTION (provided by applicant): This is a proposal to develop a keratin based resuscitation fluid that greatly improves outcomes for patients following treatment of hemorrhage. Inadequate fluid resuscitation technology has contributed to tens of thous
ands of lives lost and billions of dollars… more
Abstract:The devastating traumatic injuries sustained by warfighters in OIF/OEF frequently involve the loss of large portions of bone, muscle and skin. Current management of tissue coverage and augmentation involves the use of existing host tissue to construct, for example, muscular flaps or grafts. In many… more
Abstract:DESCRIPTION (provided by applicant): Engineered tissues are revolutionizing disease therapy in many areas of medicine. It is estimated that the total market size for all types of tissue engineered therapies was 1.5 billion in 2008. But for many t
ypes of engineered tissues, including… more
Abstract:DESCRIPTION (provided by applicant): Targeted delivery of therapeutics has been a long-term goal in clinical medicine. Of particular interest is to be able to selectively target a drug to specific cells or tissues which could benefit from the drug activity
, and avoid delivery of the drug to other… more
Abstract:The use of LDR brachytherapy after sub-lobar lung resection is the focus of a phase III NCI sponsored trial. Early clinical results from independent studies suggest that brachytherapy enables a singificant reduction in local recurrence rates versus surgery alone. Civatech Oncology and Allegheny… more
Abstract:This SBIR Phase I project will develop a technology to utilize carbon dioxide as an environmentally benign herbicide that selectively acts on common lawn weeds. This product would exploit the differences in temperature sensitivity between weedy plants such as crabgrass and desirable plants such as… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will determine the feasibility of robust, markerless, real-time tracking of a scene on a Smartphone for use in Mixed Reality (MR) applications. The problem to be solved is the expense and complexity of MR systems, thereby enabling the… more
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