Abstract:ABSTRACT: Airbreathing hypersonic weapon systems utilizing ramjet/scramjet and/or combined cycle engines will open the door to many new capabilities for the warfighter. Applications include systems ranging from small tactical hypersonic missiles, hypersonic intelligence, surveillance &… more
Abstract:This project will build on a substantial body of empirical research to develop and validate multiscale models of ultrasonic bonding during tape placement of metal matrix composite (MMC) structures. Experiments to-date have been guided by knowledge of the ultrasonic bonding of metals heuristically… more
Abstract:Carbon fiber/PEEK thermoplastic composite has advantages over both thermoset based composites and metals in the areas of weight, damage tolerance, and manufacturing costs while maintaining solvent and temperature resistance. It is proposed that substituting the existing aluminum driveshafts with… more
Abstract:At present there exists a very significant science and technology gap for the production of photocathodes that have both high quantum efficiency (QE) and long lifetime. The National Academies has identified this as an area of critical importance to the development of high-power free-electron lasers… more
Abstract:ABSTRACT: Landing Gear (LG) is one of the few critical elements which are not redundant and failure usually results in catastrophe. Current inspections center on macro aspects of fatigue in that they are only applicable during the crack propagation phase and fail to identify and sense stages of… more
Abstract:Many attempts have been made to replace electro-deposited chromium applied to internal surfaces of gun barrels. Patented EPVD process has been bench-marked by DOD programs as a fit substitute. The objective of the proposed work is to continue the investigation, development and testing of erosion… more
Abstract:ABSTRACT: The extreme toxicity of organophosphate (OP) chemical warfare agents (CWA) is due to their specific, rapid, and irreversible reaction with cholinesterase enzymes. A significant portion of this reactive nature of OP agents is directly due to the unique metabolically active environment… more
Abstract:Dried blood spots (DBS) analysis has many advantages over standard liquid blood sample testing including: small sample size, ease of blood sampling, room temperature storage, minimal storage size requirement, and ease of shipping. Although these advantages are significant, there are still problems… more
Abstract:Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for… more
Abstract:One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting… more
Abstract:Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents… more
Abstract:With no clinically approved antiviral therapy available for treatment of flavivirus infections, the development of efficient vaccines and antiviral agents for prevention and treatment of infections is an urgent health priority. A combination of structure-based in silico models, in vitro and… more
Abstract:Bacterial enteric pathogens causing travelers"diarrhea (TD) in developing countries include enterotoxigenic E. coli (50%), Camplyobacter jejuni, Shigella sonnei and Shigella flexneri, while Norovirus is a common viral cause. High risk regions for TD include areas where US service members are… more
Abstract:Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental… more
Abstract:ABSTRACT: Within the last decade, game theoretic approaches have emerged as viable tools to analyze distributed wireless resource allocation problems and design distributed transmission strategies. Conventional game theoretic designs for wireless resource allocation problems do not consider jamming… more
Abstract:ABSTRACT: The ultimate objective of the joint effort is to develop technology that will enable next-generation cognitive wireless networking between USAF space, air, and ground assets and achieve significant improvement in network throughput, delay, and reliability. Current practices that evolve… more
Abstract:DESCRIPTION (provided by applicant): Ischemic Stroke continues to be a major cause of morbidity and mortality in the United States. Currently approved thrombolytic therapy suffers for a narrow therapeutic window and clearly other therapeutic strategies areneeded, such as neuroprotective or… more
Abstract:DESCRIPTION (provided by applicant): Systemic sclerosis (SSc) or diffuse scleroderma is a complex, chronic, autoimmune, connective tissue disease which primarily causes skin thickening and hardening in addition to interstitial fibrosis of lungs, gastrointestinal tract and arteries. Estimates of the… more
Abstract:DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a progressive, agonizing, debilitating and routinely fatal disease that afflicts 200,000 individuals in the United States and five million patients worldwide. There are currentlyno effective treatments available for this… more
Abstract:DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a significant cause of morbidity and mortality in the U.S. H2 Relaxin (H2R) is a Phase III clinical trial-stage peptide that exhibits both anti-inflammatory and cytoprotective activities which can potentially be harnessed for the… more
Abstract:The objective of this project is to develop a portable, passive system for rapid and efficient blood component separation. While a number of macroscale devices (based on centrifugation) are routinely employed in laboratory settings to separate red blood cells (RBCs) and platelets from plasma, they… more
Abstract:DESCRIPTION (provided by applicant): Patient data collected during health care delivery and public health surveys possess a great deal of information that could be used in biomedical and epidemiological research. Access to these data, however, is usually limited because of the private nature of most… more
Abstract:Applied Science Innovations proposes development of metrology on corrective optics for aerodynamic domes using the improved Interferometric Tomography, building directly on ASI's successful development of a new tool for metrology on conformal aspheric windows, domes and corrector optics. The… more
Abstract:Applied Science Innovations proposes Phase II development of metrology on corrective optics for aerodynamic domes using the improved Interferometric Tomography, building directly on ASI"s successful development of a new tool for metrology on conformal aspheric windows, domes and corrector… more
Abstract:This project will develop a decision tool for Load and Route Evaluation for Dismounted Operations (LAREDO). The research efforts will expand upon infantry routing algorithms and decision tools we are developing for the Army"s Geospatial Engineering Center. LAREDO will provide an interactive 3D… more
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