Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop nanoparticle imaging agents for diagnostic applications in clinical pathology. Currently, fluorescent imaging agents are used to image cells and tissue samples in both solid (biopsy) and liquid (blood sample) forms and to… more
Abstract:The proposed research effort explores the use of a nanosecond pulse driven offset semiconducting surface dielectric barrier discharge (SSDBD) device for the control of high speed, near surface air flows and the reduction of skin friction drag. With the nanosecond discharge, very high field… more
Abstract:Most time resolved studies to date have made use of readily available visible and near-visible pump sources to trigger the events and, thus were able to study only a small subset of phenomena. Recently, investigations of the dynamics stimulated by THz pulses have led to advances like… more
Abstract:High quantum efficiency (QE) photocathodes are central for efficient photoinjectors and ultra-fast electron microscopes. Current high QE photo cathode materials like GaAs, alkali-tellurides and alkali-antimonides require ultra-high vacuum and even then have a short life time. Moreover, most of these… more
Abstract:The principal goal of this project is to develop two RF power extraction structures (an X-band and a W-band device) to demonstrate high power high frequency RF generation using high current relativistic electron beams. High power high frequency RF sources have compelling applications in accelerators… more
Abstract:The laser plasma accelerator (LPA) is a very promising technology for generating gamma rays for the detection of contraband bulk nuclear materials, but is currently limited by the rate at which the beam can be pulsed. Erosion of the capillary plasma channel is the main limiting factor and can be… more
Abstract:Multipactor discharges in dielectric accelerating structures are a major limitation on the performance of this otherwise very promising technology for future high energy physics machines and other applications. We will experimentally study a new approach, using an external… more
Abstract:Both superconducting and conventional accelerating structures require fast electronic control of the input rf power. A fast controllable phase shifter would allow for example the control of the rf power delivered to multiple accelerating cavities from a single power amplifier. Nonlinear… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project concerns a major health concern both here in the US and abroad. Currently, no long-term vaginal delivery device is available for the delivery of proteins such as are being investigated for HIV prevention. Our long-term goal is to prevent… more
Abstract:DESCRIPTION (provided by applicant): Navidea Biopharmaceuticals is developing 18F-AZD4694 as a diagnostic imaging agent to be used with PET scans to directly visualize beta amyloid (A ) deposits in the brains of living patients. A deposits in the brains of patients with dementia are diagnostic for… more
Abstract:DESCRIPTION (provided by applicant): Navidea Biopharmaceuticals is developing [18F]NAV4694 as a diagnostic imaging agent that can be used to visualize beta-amyloid (A) plaques in the brains of living individuals. Alzheimer's disease is the leading cause ofdementia. All patients with dementia… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project presents novel approaches to fabricating dry, removable, reusable adhesives on substrates using scalable fiber spinning methodologies. The proposed work differs drastically from other research programs to replicate bio inspired adhesive… more
Abstract:HexEffect, LLC will use its experience with both offensive and defensive computing technologies to develop a software-only root of trust (RoT) system
called DynaTrust. The system will be deployable on commercial mobile devices running the Android operating system. The purpose of DynaTrust is… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project is intended to demonstrate the disinfection efficacy of a novel non-thermal-plasma-generating technology that produces a variety of reactive ionic species. Non-thermal plasma discharge has been found to be disruptive to normal bacterial,… more
Abstract:DESCRIPTION (provided by applicant): The long term goal of this project is to develop and commercialize noninvasive equipment, called the sleep and respiratory track (SARTrak) system, for high throughput detection of sleep apnea in animals. The specific goal for the Phase I application is to design… more
Abstract:DESCRIPTION (provided by applicant): We seek to develop a rapid-acting U-500 insulin analog formulation for patients with Type 2 and Type 1 diabetes mellitus (T2DM and T1DM). Such a novel product would improve treatment in two contexts: (i) for T2DM patients with marked insulin resistance (as… more
Abstract:DESCRIPTION (provided by applicant): Close-loop systems of insulin delivery-comprising an insulin pump, continuous glucose monitor, and feedback-based control algorithm-provide a promising technology to enable tight glycemic control in Type 1 diabetes mellitus with improved patient convenience and… more
Abstract:Controlling emissions and increasing efficiencies are essential requirements in future advanced power plants. Herein, next generation power systems require greater flexibility in their operations for meeting the higher efficiency and lower emissions conditions that are geared toward meeting consumer… more
Abstract:Despite the growth in Simulation tools and methods over the past two decades, the ability to access this technology is still outside the reach of many small and medium sized engineering companies the so called missing middle. The National Center for Manufacturing Science (NCMS) report that access… more
Abstract:Based upon nVision Technology employee's experience developing the DARPA One Shot system and the VALR wind measurement system through another DoD customer, nVision Technology proposes using scintillation-based wind measurement techniques for both passive wind measurement as well as… more
Abstract:ABSTRACT: The Cetane numbers for individual fuel components have been extensively tabulated To determine the Cetane number of the resulting fuel blend, algorithmic models have been developed that provide accuracy on a par with standard lab-based cetane tests. Utilizing comprehensive two dimensional… more
Abstract:There is a great need and opportunity to develop lower cost manufacturing process for ceramic tile-based composite armor system for military tactical vehicles. The threat levels encountered by the military tactical vehicles, particularly due to the Improvised Explosive Devices (IED) pose an… more
Abstract:The research objective of this proposal is to demonstrate a semi-automated association process based upon photometric and astrometric data collected by deep space sensors for UnCorrelated Tracks (UCTs) found in and near the Geosynchronous Earth Orbit (GEO) regime. We will derive a method for… more
Abstract:DESCRIPTION (provided by applicant): A major public health concern in recent years has been increasing reports of adverse cardiac events, including sudden cardiac death, that have been associated with use of non-cardiac drugs. In fact, in the last 15 yearssix non-cardiac drugs had to be withdrawn… more
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