Abstract:DESCRIPTION (provided by applicant): Paroxysmal Nocturnal Hemoglobinuria (PNH) is an orphan disease characterized by severe anemia, kidney and liver failure, and ultimately death, if left untreated. In 2007, FDA approved the first complement inhibitor, Eculizumab (Soliris(R)), for the treatment of… more
Abstract:DESCRIPTION (provided by applicant): Complement system play a role in preventing inflammation and joint immobility. Osteoarthritis (OA), an inflammatory disease of the joints, is quite prevalent among the elderly and causes disability in nearly 10% of thepopulation over 55 years. Current… more
Abstract:DESCRIPTION (provided by applicant): The goal of this proposal is to develop tumor necrosis factor (TNF )-inhibiting compounds as neuroprotectant drugs for treating Alzheimer's disease (AD). Current FDA-approved AD interventions are symptomatic treatments with limited efficacy which do not… more
Abstract:ABSTRACT: The overall objective of the proposed SBIR program is to rapidly advance and optimize the manufacturing of dual-use carbon fiber/polyimide matrix composites with high thermo-oxidative stability (TOS) for use in aircraft components with service temperatures exceeding those of PMR-15. This… more
Abstract:DESCRIPTION (provided by applicant): An estimated 11.5 percent of adults (approx 23 million people) suffer from chronic kidney disease. Among people suffering from ESRD, the mortality is approximately 163.8 deaths per 1,000 patient years. Hemodialysis is the leading treatment for more than 341,000… more
Abstract:Development of a solid with high conductivity of Mg2+ cations will allow application of that substance as membrane in magnesium-air batteries. These batteries will be much cheaper, safer, and at the same time store much more energy than lead-, lithium- or sodium batteries with the same weight.… more
Abstract:In this proposed Phase I Project, Powdermet will develop a low cost solution to contamination issues currently involved in spherical plain airframe bearings. The proposed solution will utilize an advanced low friction cermet. This material will be capable for application as a powder coating or… more
Abstract:Powdermet perceives the Phase I program as a success on the basis of achieving state-of-the-art properties in polymer thin film materials and observation of key phenomenon that will enable even greater gains in the state of the art. The microstructure of the thin films reveal both continued… more
Abstract:ABSTRACT: The overall program objective is to utilize the best available technologies to successfully develop the concept and design of a state of the art C-Band telemetry transmitter that meets or exceeds the performance qualification parameters and size constraints detailed in the AF12-BT07… more
Abstract:ABSTRACT: There are numerous military applications where incorporation of Anti-Jam (AJ) GPS technology has been constrained by Size Weight and Power (SWaP), including handheld systems, unmanned aerial or ground vehicles, and munitions/weapons. The essential elements for incorporating AJ capability… more
Abstract:ABSTRACT: Rapid detection and analysis of signals over a wide frequency band in a dense signal environment continues to be an area requiring further research and development. RBS Technologies, LLC has pursued two high performance architectures for a High Resolution Wideband Direct Conversion… more
Abstract:The modeling data provides valuable insight into actual and potential climate changes, and has the po- tential to be leveraged by other researchers (e.g., agriculture, water resources, energy) and commercial users (who have requested access to such data). Despite the need for such data, only… more
Abstract:Due to huge levels of computing parallelism and higher performance per watt, comuting accelerators are crucial for increasing HPC efficiency. This is economically significant for small and medium size manufacturing companies (SMMs) and essential for transition to Exascale computing. However, due… more
Abstract:With the capacity and performance of FPGAs suitable for space borne applications continuously increasing, the design of FPGAs is becoming increasingly complex involving trading off or simultaneous optimization of space, speed, and power. RNET and ANL are proposing to develop software infrastructure… more
Abstract:ABSTRACT: RNET and The Ohio State University propose to use algorithmic modifications and multi-level parallelization techniques and tools to improve the scalability of the aero-line/aero-elastic coupled CFD/CSD codes relevant to the DoD/AF (e.g., CREATE/Kestrel). The optimizations will address… more
Abstract:ABSTRACT: In an attempt to address the data overload challenge significant work has been conducted studying the human factors and cognitive science issues related to exploitation of"big data". Also, significant investment has been made in automated or autonomous processing/exploitation… more
Abstract:ABSTRACT: Database sustainability is a fundamental challenge for supporting assisted and automatic target recognition algorithms. We propose a new approach to SAR/HRR exploitation algorithms that emphasizes simple, well-understood target morphology and the corresponding scattering physics generated… more
Abstract:ABSTRACT: Bundle adjustment is a commonly employed technique for backing out camera parameters and 3D image models from a set of images. The generic case of bundle adjustment (overlapping shots from arbitrary cameras at arbitrary locations and times) has been highly optimized, and is used to good… more
Abstract:Sierra Lobo proposes to develop a technology that can provide both cooling and electric power generation using heat. When coupled with a radioisotope heat source, the technology is ideally suited to the needs of a long-lived Venus lander. The heat source powers Sierra Lobo's Thermoacoustic… more
Abstract:The proposed load-bearing, tank-applied, multi-layer insulation system consists of a set of highly reflective radiation shields made from 1 mil thick aluminized Mylar that is supported from a "pop-up tent like" support frame. In addition, the support frame carries the mass of an actively… more
Abstract:The U.S. Department of Energy has determined that a need exists to develop a more fundamental and detailed understanding of the basic physics and chemistry of low temperature plasmas (LTP) ( & lt;10 eV). These non-equilibrium LTPs have a multitude of applications ranging from semiconductor… more
Abstract:ABSTRACT: Spectral Energies, LLC in collaboration with the University of Notre Dame and Georgia Tech proposes to develop and deliver flow control approaches for mitigating adverse effects of shock formation, unsteadiness, and shock-induced separation on aero optical turrets. During Phase I, one… more
Abstract:ABSTRACT: The objectives of this Phase-II research effort are to perform various advanced laser-based measurements in a swirl stabilized combustor test cell, in a high-pressure combustor, and turbulent laboratory flames for various hydrocarbon fuels in order to identify suitable technologies as… more
Abstract:ABSTRACT: This Phase-I research effort is designed to forward the engineering investigation of the dynamics and control of turbulent combustion in high-pressure combustion systems by developing a set of game-changing nonlinear analysis tools that can significantly improve the post-processing speed… more
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