Abstract:DESCRIPTION (provided by applicant): According to the NIAID fact sheet on Botulism, the extreme toxicity of botulinum neurotoxins (BoNT) and the ease of production, transport, and delivery make this an agent of extreme bioterrorism concern. Nonetheless, although there are major vaccine… more
Abstract:DESCRIPTION (provided by applicant): Although a rapid and accurate diagnosis is crucial to the management of patients suspected of bacterial infection, the currently available radiopharmaceuticals are not capable of distinguishing between sterile inflammation and bacterial infections. Our goal is to… more
Abstract:This SBIR is to design, test and manufacture a state of the art, low profile, low drag SATCOM antenna system for millimeter wave Ku and Ka band transmissions from an airborne platform. The concept will enable bi-directional high data rate transmissions capable of handling imagery and communications… more
Abstract:DESCRIPTION (provided by applicant): The medical evaluation of patients with balance and equilibrium complaints includes an assessment of their vestibular function. However, standard clinical tests of vestibular function have a number of limitations that reduce their ability to provide an adequate… more
Abstract:Prognostic monitoring capabilities for space exploration aircrafts are crucial to enable safety and reliability in these platforms. Nokomis proposes to develop and mature a system which exploits electromagnetic emissions to identify degradation in avionics components and determine the probability… more
Abstract:Acoustic air purification systems could be an important technology for protection of buildings from terrorist biological threats. The current limitations of these systems (e.g. cost, size, and power consumption) are mainly due to the inadequacy of commercially available sound sources for this… more
Abstract:ABSTRACT: Paramount has previously developed thermal controls for the SLS process and documented some of the required in-situ sensing capabilities to achieve full process stability. Paramount"s partners have previously modeled the laser energy density for the process and other composite… more
Abstract:In Phase II, PiAC and CMU plan to develop and demonstrate an operational prototype of a VERTREP Object Proximity Warning System (OPWS) sensor and software. The prototype will be evaluated in a subscale demonstration using the actual sensor package and a surrogate mechanical system to simulate… more
Abstract:DESCRIPTION (provided by applicant): Over 40 million Americans suffer from hypertension. Timely diagnosis and control of high arterial blood pressure (AP) are crucial for preventing life-threatening complications and end-organ damage but have been hamperedby the lack of nondisruptive monitors for… more
Abstract:DESCRIPTION (provided by applicant): Although the USPHSTF, SAMHSA, the CDC, and NIAAA have affirmed the central role that healthcare providers play in screening, brief intervention, and referral to treatment (SBIRT) for alcohol abuse, translation of theserecommendations to clinical practice… more
Abstract:DESCRIPTION (provided by applicant): The proposed Polaris EECD (Engagement Enhancement for Chemical Dependency/EECD) system will facilitate adoption and strengthen the impact of two evidence based practices for chemical dependency treatment. It will improve treatment engagement and outcomes.… more
Abstract:DESCRIPTION (provided by applicant): Malaria is a global disease causing gt 500 million clinical cases and gt 1 million deaths each year. Moreover, drug resistant Plasmodium falciparum has become a major problem. Therefore, it is crucial to discover new classes of drugs for anti-malarial drug… more
Abstract:DESCRIPTION (provided by applicant): Oral ulcerative mucositis is a common, painful, dose-limiting toxicity of chemotherapy and radiation therapy for cancer, and represents an important unmet clinical need with 450,000 Americans suffering from mucositis each year. It impacts virtually all patients… more
Abstract:DESCRIPTION (provided by applicant): As in the past, most new FDA-approved drugs for cancer and other indications are derived from natural products or inspired by natural products. Accordingly, it is proposed here to screen the NCI collection of extracts to discover novel molecules that inhibit the… more
Abstract:DESCRIPTION (provided by applicant): Because of its involvement in a broad range of cellular signal transduction and other mechanisms, the ubiquitin pathway is now recognized as a new opportunity for discovering drugs to treat a variety of diseases. Initial success was achieved with the approval of… more
Abstract:DESCRIPTION (provided by applicant): Approximately 70,000 individuals worldwide suffer from the debilitating disease cystic fibrosis (CF), which typically is fatal owing to sepsis in the abnormally viscous mucus of the lung. Various treatments are employed to address symptoms, but an approved drug… more
Abstract:Missile exhaust plume radiant emission is a key observable for any missile defense system using optical sensors. Scene generation has become an important component within MDA to assess the performance of the BMDS system, and accurate rendering of the target during boost is essential for proper… more
Abstract:Vernier engines operating at the same time as the main missile engine can change the overall structure of the engine exhaust plume. This SBIR focuses on the modeling of this interaction using techniques that do not require the use of high fidelity 3-D CFD computations. The proposed approach will… more
Abstract:ABSTRACT: An exhaust plume is a primary observable to warning sensors designed to protect low flying aircraft from MANPADS and other hostile threats such as RPG's and small arms fire with tracers. The design of current and future warning sensors and countermeasures need a complete… more
Abstract:Missile defense systems like AEGIS and THAAD depend upon having prior knowledge of the signature characteristics of the threat missile in order to perform the necessary system functions to defeat the threat. Thus, the role of signature simulation (both radar and optical) technology is critical for… more
Abstract:This effort is to develop an evidence-based scientific Brain Fitness Training (BFT) program to accelerate brain growth and improve cognitive function. The goal is to create a mobile computing technology that can be used during initial military training or pre-entry training to raise the domain… more
Abstract:Individual differences in vulnerability to sleep loss and fatigue from extended work hours and night work are a substantial problem in transportation policy making, work schedule development, fatigue risk management strategies, and prediction of performance impairment in real-world operations (Van… more
Abstract:Given the extended duration of future missions and the isolated, extreme, and confined environments, there is the possibility that stress-related behavioral conditions and mental disorders (DSM-IV-TR) will develop. The overarching goal of this project is to deliver an integrated system that will… more
Abstract:Purpose: Braille is the primary medium of written communication for persons who are blind. Prior research shows that Braille literacy strongly correlates with stronger reading habits and the pursuit of higher education, whereas Braille illiteracy negatively impacts students' academic performance and… more
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