Abstract:The proposal represents a radical revolution in Power Management & Distribution (PMAD) that addresses many of the challenges for NASA missions that will operate in harsher space environments. One of the several advances it introduces is to eliminate the number one problem of electronics failure… more
Abstract:The over dependence of the United States on fossil fuels from foreign countries as the predominant source of energy and chemical feedstocks has placed the United State in an alarming position, impacted our national energy security and threaten the ecologic balance and the environment we… more
Abstract:The integrity of water piping infrastructures is essential for providing safe drinking water and for the treatment of wastewater. As pipelines age, they deteriorate, corrode, and crack. Existing techniques, such as visual observation and closed circuit TV, for assessing piping integrity are… more
Abstract:ABSTRACT: FBS proposes to develop an ultra light-weight ultrasonic guided wave deicing/anti-icing retrofittable system for Remotely Piloted Aircraft (RPA). This system will utilize a focusing/phasing technique to direct and focus energy along specified areas along the leading edge. An anti-icing… more
Abstract:The recent use of materials, such as 5xxx-series aluminum in new ships is posing new challenges in inspection for the Navy; as future performance of these materials over time is not as well known. Current state of the art off the shelf techniques have not proven to be viable options for monitoring… more
Abstract:The objective of this SBIR Phase I effort is to develop an innovative fabrication method to produce high IR transmission and hardness aspheric window, which includes following major efforts: First, a unique composite ceramic material will be developed, which not only is highly transparent over a… more
Abstract:The objective of this SBIR Phase II effort is to grow larger size (50 mm diameter x 25 mm thick or larger) single crystals of aluminum oxynitride (AlON) and aluminum nitride (AlN) by refining and optimizing the rapid and contamination free growth method developed at the Phase I stage. The major… more
Abstract:General Sciences, Inc. (GSI) will design, produce, evaluate and characterize reactive shaped charge liners (RSCL) that possess high density (9-16 g/cc), exothermicity (T>2000K), storage stability and the ability to defeat improvised explosive devices (IEDs), chemical and biological weapons and… more
Abstract:The proposed program addresses the development of a safe to breathe smoke consisting of mainly TiO2 and KCl particulates with the option of including fog oil as well in a hybrid device configuration. The effort will address further smoke characterization as well as scale-up to a 5"(dia) by… more
Abstract:Low visibility rotary aircraft decoys are needed to protect vehicles against heat seeking missile attacks without illuminating the target which exposes the aircraft to small arms fire and potentially compromising the mission. The novel approach to this challenge is to produce a decoy which emits… more
Abstract:The US Army, as well as other national military services, requires new and innovative energetic/reactive materials to produce next generation munitions. Munitions of today contain a high amount of inert material, usually steel, that serves as structural elements and fragment generation. General… more
Abstract:DESCRIPTION (provided by applicant): There is a well-recognized need to develop vaccines that stimulates humoral immunity as well as a potent T cell immunity in order to achieve protection from infection with pathogens. Although numerous investigations arefocused on developing vaccines that induce… more
Abstract:This project builds on patterns derived from natural antimicrobial peptide sequences to develop novel compounds with better systemic activity, lower cytotoxicity and broader spectrum activity against multidrug resistant (MDR) pathogens. In Phase I and the
Abstract:DESCRIPTION (provided by applicant): This is a proposal to develop newly discovered sulfamoylbenzamide derivatives as therapeutic agents for the treatment of chronic hepatitis B virus (HBV) infection. These molecules have been identified as inhibitors of HBV pregenomic (pg) RNA encapsidation, a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a design concept and demonstrate the feasibility of a continuous process to produce low-cost silicon wafers for solar cells. The approach is to cool a molten bath of silicon from the top to be below its melting point,… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to develop a pilot-scale production system and process to enable the large-scale fabrication of continuous arrays of elastomeric micro/nano-scale fibers with complex geometry. Inspired by hairs that occur naturally on gecko feet,… more
Abstract:DESCRIPTION (provided by applicant): When presented with a suitable antigenic Envelope (Env) structure, the human immune system can produce protective antibodies that HIV is unable to evade. Many of the most potently neutralizing HIV antibodies identifiedto date preferentially bind the trimeric… more
Abstract:DESCRIPTION (provided by applicant): We propose to use a novel technology, the Lipoparticle, to capture and concentrate structurally intact membrane proteins in a format amenable to phage panning for MAb isolation. The use of Lipoparticles to pan phage display libraries represents a valuable… more
Abstract:This Phase II SBIR proposal responds to a CBD need for improved Acoustically Enhanced Impaction (AEI) air purification in support of low pressure drop filtration. Prior to the SBIR Phase I effort, a first generation/benchmark (AEI) system developed by Applied Research Associates, Inc. (ARA)… more
Abstract:Detection and tracking of moving vehicles and dismounts across the land-sea boundary is very challenging because of the highly complicated dynamic heterogeneous littoral clutter environment. LSI proposes knowledge based adaptive signal processing techniques that will ultimately sense the dynamics of… more
Abstract:Sensor exploitation management is a key enabling technology to optimally use the capabilities of airborne radar systems with and without an operator-in-the-loop. LSI proposes to develop this capability to compliment a sensor resource manager capability that when integrated will result in… more
Abstract:Surface vessel detection and classification from airborne platforms relies heavily on radar at operationally useful stand off ranges. Upon detection the radar search waveform may be used to accrue additional information about the surface contact for classification but confidence is likely to be… more
Abstract:DESCRIPTION (provided by applicant): In the last decade there has been an explosive growth in the field of ubiquitin research, with approximately 530 human genes predicted to encode enzymes involved in the conjugation and deconjugation of ubiquitin. Of these 95 encode for deubiquitylases (DUBs). In… more
Abstract:DESCRIPTION (provided by applicant): Identification, quantification, and isolation of low abundance proteins from complex mixtures is, at best, a difficult task. This is especially the case for proteins carrying a post-translational modification (PTM) that affects their half-life or regulatory… more
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