Abstract:DESCRIPTION (provided by applicant): Our overall goal is to develop a urine DNA-based screening test for the early detection of colorectal cancer (CRC) that is noninvasive, patient-friendly, and more sensitive than existing noninvasive screening tests. Despite the availability of colonoscopy, the… more
Abstract:DESCRIPTION (provided by applicant): Hepatocellular carcinoma (HCC) and intrahepatic cholagiocarcinoma (ICC) usually go undetected until its late stages, with a 5-year survival rate less than 10%. The survival rate can, however, be as high as 40% ifcancer is detected early. Unfortunately,… more
Abstract:DESCRIPTION (provided by applicant): The product that will be developed by MedVas Concepts is a drug targeting vehicle for cancer therapeutics used in combination with radiation therapy. The product uses a feature of ionizing radiation to match drug delivery selectivity with that of the radiation… more
Abstract:DESCRIPTION (provided by applicant): Better therapies are needed to treat malignant melanoma, the most deadly form of skin cancer. Multiple pathways such as STAT, MAP and PI3 kinase are deregulated in the development of melanoma, and targeting these pathways in melanoma cells, could be used as a… more
Abstract:****NOTICE: ABSTRACT EXTRACTED FROM APPLICATION FOR REPORTING CATEGORIES AND DISEASE CODING (RCDC). THIS TEXT HAS NOT BEEN PROOFED BY SRA. WHEN THE UPLOADED ABSTRACT IS NOT IN THE EXPECTED FORMAT, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE.**** Project Summary: The overall goal of the… more
Abstract:DESCRIPTION (provided by applicant): Hospital discharge planning is a frequently occurring and expensive hospital care process done annually for more than 13 million Medicare beneficiaries. The process has multiple steps that require careful, comprehensiveassessment to adequately determine… more
Abstract:DESCRIPTION (provided by applicant): Our objective is to provide patients and physicians with an effective new tool to increase patient compliance (aka adherence) to prescription drug regimens. Poor patient compliance diminishes patients' health, increasespreventable morbidity, and results in… more
Abstract:DESCRIPTION (provided by applicant): Huntington's disease (HD) is a neurodegenerative disorder characterized by chorea and progressive motor, psychiatric and cognitive decline. GM1 depletion is validated as a therapeutic target for Huntington's disease (HD) in preclinical studies in which… more
Abstract:DESCRIPTION (provided by applicant): Recent key scientific discoveries have identified oligomers of the protein Abeta 42 as the synaptotoxic culprits in the Alzheimer's disease process. With increasing age, decline in brain levels of Abeta binding and clearance proteins and elevations in enzyme… more
Abstract:DESCRIPTION (provided by applicant): The objective of this research application is the development of a simple, highly portable test system for rapid screening for human immunodeficiency virus (HIV) and hepatitis at the point of care (POC). This test system will be capable of identifying patients… more
Abstract:Lightweight robotic excavators address the need for machines that dig,collect, transport and dump lunar soil. Robust and productive smallrobots enable mining rich and accessible deposits of ice and othervolatiles buried near craters at the lunar poles, delivering resources toproduce propellant, and… more
Abstract:A scalable gravity offload device simulates reduced gravity for the testing of various surface system elements such as mobile robots, excavators, habitats, and deployables in a relevant environment. The device is capable of simulating reduced gravity over an arbitrary terrain including such… more
Abstract:The combined team of Neya Systems, LLC (NSL), and Carnegie Mellon University (CMU), propose to develop the Casualty Evacuation Mission Management System (CEMMS), an effort that will provide significant opportunities to: 1. Develop a Domain Specific Language (DSL) that enables translation from… more
Abstract:As robots become more widely employed in tactical operations and gain greater autonomy for doing simple tasks, they must become more integrated into the processes of mission planning and management. This integration will come by means of standardized command and control interfaces mandated by the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop efficient manufacturing of nanostructured flexible transparent conducting electrodes (TCEs) with low resistivity and high durability. Flexible nanostructured TCEs will be produced by using the proprietary… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposal to the U.S. Department of Defense (DoD), Navy, requests funding for Innova Dynamics, Inc. to enable innovative manufacturing of robust, non-delaminating, highly conductive aircraft transparency materials through Innlay… more
Abstract:The development of an intelligent, commercially available remote electro-optic/infrared surveillance system using the appropriate mix of agent technology, infrastructure, and personnel is critical to establishing and maintaining effective control of U.S. air, land, and maritime borders. The… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop a non-invasive alternative to radionuclide shunt patency testing for evaluating Normal Pressure Hydrocephalus (NPH) patients with suspected shunt malfunction. Hydrocephalus is a disorder of cerebrospinal fluid dynamics that is… more
Abstract:DESCRIPTION (provided by applicant): This Phase 1 SBIR will develop Continuous Real Time (CRT) ShuntCheck, the first portable, non- invasive device for real time, continuous monitoring of flow in CSF shunts. This device will result in improved clinicalmanagement of hydrocephalus by providing a… more
Abstract:DESCRIPTION (provided by applicant): This Phase 2 SBIR will provide and clinically validate the first portable, non-invasive diagnostic test for differentiating intermittently flowing patent shunts from occluded or partially occluded shunts - ShuntCheck- Micro-Pumper. This device will result in… more
Abstract:This Small Business Innovation Research Phase I project will investigate the use of novel manufacturing methods to fabricate porous ceramic substrates for reducing pollution from large diesel engines, and burners. Currently, these substrates are extruded, and are thus constrained in size, shape, and… more
Abstract:In this proposal Zeomedix proposes to develop a dressing for acute trauma wounds based on its alginate/zeolite encapsulating nitric oxide (NO) technology. Nitric oxide has been shown to enhance the wound healing process as well as act as a powerful antibacterial agent. However, delivery of nitric… more
Abstract:Phishing attacks fool end-users into disclosing sensitive information (e.g., passwords, trade secrets, and national security secrets) or installing malware on their computers. While a number of automated solutions have been developed to mitigate these attacks, these solutions have drawbacks in terms… more
Abstract:This Small Business Innovation Research (SBIR) Phase 1 project will demonstrate a novel micro-scale thermal management concept for removing waste heat generated in the active regions of a pulsed semiconductor device. In these devices, each duty cycle consists of a period of heat generating pulse on… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will develop an advanced heat sink and a two-phase pumped loop for cooling high power laser diodes and other high heat flux devices. An advanced coating will be applied to the heat sink to enhance the boiling process, suppress flow… more
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