Abstract:DESCRIPTION (provided by applicant): A large body of evidence indicates that the cognitive impairment and delayed neurodegeneration in traumatic brain injury (TBI) is caused by increased accumulation of tau, phosphorylated tau (p-tau) and other neurotoxic proteins including APP and… more
Abstract:Washburn Therapeutics Inc. is developing biologically active gels that control inflammation by selectively neutralizing pro-inflammatory cytokines based on a technology being licensed exclusively by the company from Carnegie Mellon University. Preliminary results demonstrated that conjugates of… more
Abstract:In an effort to support the development of a domestic marine aquaculture industry, Zeigler Bros. Inc., (ZBI) proposes to continue its Phase I research by demonstrating the ability to scale up inclusion particle (IP) manufacturing. During Phase II ZBI will also demonstrate the efficacy of IOs for… more
Abstract:The innovation is a new approach to structuring, collecting and using historical geospatial data that will make it possible to rapidly assign a geographic location for text descriptions appearing in historic documents. Geospatial location is a critical element of most documents, and historical… more
Abstract:E. coli are common bacteria and part of the normal flora of the GI tract. Some strains, including the Shiga toxin-producing E. coli (STEC) are able to produce a toxin (Shiga toxin), which can lead to serious human illnesses from mild diarrhea to life threatening conditions, such as hemolytic uremic… more
Abstract:Advanced Cooling Technologies, Inc. (ACT) proposes to develop a thermal management system for cabinet cooling that focuses on the use of silent and primarily passive cooling methods. The passive cooling methods selected have inherently low thermal resistances and will allow the ultimate heat sink to… more
Abstract:This proposal describes a program by Advanced Cooling Technologies, Inc. (ACT) that will develop a missile engine waste heat recovery system for recharging the batteries of a missile. The proposed system will use heat pipes to transfer the waste energy from the insulation around a missile engine. … more
Abstract:ABSTRACT: The purpose of the proposed SBIR program is to develop a thermally enhanced, separable thermal mechanical interface (STMI) that aims to significantly enhance heat transfer by providing a direct thermal path from the high power density components to the heat sink. In the current… more
Abstract:Solar water heaters are an efficient means to harvest energy from the sun to heat water for domestic use (i.e. bathing, washing dishes, etc.). However, the current solar water heating systems cost approximately $133/ft2 and have a payback period of 7-10 years, including incentives and rebates,… more
Abstract:This Small Business Technology Transfer (STTR) Phase 1 project will develop a novel methodology to build atomistically-informed chemical kinetics models for oxidation and pyrolysis in particulate filled-rubber composite materials. In Navy operations, these materials are widely used under extreme… more
Abstract:Advanced Cooling Technologies, Inc. (ACT) proposes an innovative heat exchanger integrated with thermoelectric devices to achieve 10-15 kW additional cooling capacity to the current Liquid Cooling System (LCS) aboard the E2-D Advanced Hawkeye. The proposed heat exchanger will reduce the cold side… more
Abstract:NASA Glenn Research Center (GRC) is developing fission power system technology for future space transportation and surface power applications. The early systems are envisioned in the 10 to 100kWe range and have an anticipated design life of 8 to 15 years with no maintenance. A non-nuclear system… more
Abstract:NASA Glenn is examining small fission reactors for future space transportation and surface power applications. The reactors would have an 8 to 15 year design life and should be available for a 2020 launch to support future NASA science missions. Both 1 kWe thermoelectric and 3 kWe Stirling systems… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop and demonstrate a thermal ground plane (TGP) technology with improved manufacturability and reliability over previous technology generations. Advanced Cooling Technologies, Inc. is developing ultra low thermal resistance and… more
Abstract:ABSTRACT: This Small Business Innovation Research (SBIR) Phase I project proposes to enhance the combustion energy of liquid propellants via addition of stabilized aluminum nanoparticles. Aluminum oxidizes readily to create aluminum oxide and releases 30% more heat per unit volume than kerosene.… more
Abstract:Fiber reinforced composites are attractive for several light-weight defense and aerospace applications. However, their inherent anisotropy and complex failure mechanisms limit their use in high-performance structures or components. In order to accurately predict the damage behavior and durability of… more
Abstract:Corrosive environments together with cyclic loading can lead to the formation of localized corrosion pits and corrosion fatigue cracks, which can significantly deteriorate the structural integrity of aircraft components. The exact nature of corrosion fatigue damage is dependent on the competing… more
Abstract:This Small Business Innovation Research (SBIR) program will develop a thermoelectric generator (TEG) that will improve the overall efficiency of 100-kW class generator sets (gensets) by 5-10%. Advanced Cooling Technologies, Inc. (ACT) proposes a novel heat-pipe embedded thermoelectric generator to… more
Abstract:DESCRIPTION (provided by applicant): Radiation-induced production of pro-inflammatory and pro-fibrotic cytokines results in chronic and irreversible damage to the lungs. To date, no agent has demonstrated a sufficient safety profile to be utilized as a clinical drug for mitigating damage from… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop a noninvasive intracranial pressure (ICP) monitor based on a pilot clinical study correlating ocular blood pressure and blood flow parameters to ICP. The proposed novel device will combine several standard medical… more
Abstract:High temperature reliability is needed to design distributed power conditioning systems in next generation, high power density SiC and GaN-based electronics. New high energy density capacitors are needed to reduce the volume and weight of power conditioning modules and high temperature reliability… more
Abstract:We propose to develop cost-effective velocity vector sensor technology by reducing costs to the accelerometers within the device. By optimizing both crystal and hardware, single crystal materials costs can be reduced. TRS will also evaluate assembly of sub-structures to reduce labor through… more
Abstract:TRS proposes to develop a countermeasures transducer of approximate spherical shape from single crystal piezoelectrics from one of two designs. Using the advantages of different crystal modes, TRS can leverage knowledge from similar programs based on cylinders to produce small, high power and… more
Abstract:This Small Business Innovation Research Phase I project will investigate the synthesis of electrochromic materials to fabricate a sensor for hazardous static voltage. This device will visibly warn of the build-up of dangerous static charge on a surface. In prior work, we have developed… more
Abstract:As deployed UxVs and the range of their applications continue to increase, the responsibility of the UxV operator has likewise shifted to encompass simultaneous control of an aggregate of multiple vehicles from multiple warfare domains. In this new aggregated paradigm, replanning, retasking, and… more
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