Abstract:DESCRIPTION (provided by applicant): Severe shortages of donor organs limit the use of orthotopic liver transplantation (LT), the only proven therapy for end-stage liver diseases. Primary non-function (PNF) of liver grafts after transplantation typically r
esults in recipient death or necessitates… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project will develop and commercialize a novel Lithographic Gelcasting (LGC) manufacturing process for microdevices that is amenable for economical volume production. Molds will be made using photolithography and filled with nanoparticulate… more
Abstract:DESCRIPTION (provided by applicant): Fast and effective communication is the key to minimizing confusion, anxiety, and casualties both during and after a public health emergency. The ability of emergency services personnel to relay clear instructions, part
icularly to vulnerable populations, results… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research Phase I project will involve the development of a noninvasive intracranial pressure (ICP) monitor based on a pilot clinical study correlating ocular blood… more
Abstract:DESCRIPTION (provided by applicant): The product that will result from this proposal will be a potent biological regulator of innate immunity, 1- peptidyl-2,3-diacylglyceride (PDAG), for use in the prevention of hospital-acquired (nosocomial) infections i
n highly-susceptible patient populations.… more
Abstract:DESCRIPTION (provided by applicant): To reduce the incidence of pressure ulcers, administrators of long term care facilities must identify which care processes need improvement and measure if their management interventions are effective. Currently, this is
difficult because the reliability of care… more
Abstract:DESCRIPTION (provided by applicant): Sexual dysfunction is one of the most prevalent and persistent problems after cancer treatment. This Fast Track STTR will create and evaluate a multimedia educational and counseling tool to promote recovery of sexual sa
tisfaction in men treated for cancer.… more
Abstract:DESCRIPTION (provided by applicant): A Potential New Drug for Depression, an active SBIR Phase IIa award. The requested funds will allow additional characterization studies of three newly discovered mixed vasopressin 1a/1b antagonists, studies that were not part of the original application. These… more
Abstract:DESCRIPTION (provided by applicant): Hybrid Nanochannel Arrays for Single Molecule Linear Genome Analysis Abstract The objective of this proposal is to develop a fully integrated nanofluidic device for single molecule analysis of long, linearized, native s
tate genomic DNA. The project will result… more
Abstract:BDC is developing a process called SMART BLEND(TM) for inspecting blended IBRs/Blisks. IBRs are susceptible to foreign object damage and blending is a relatively low cost method using machining to repair that damage. The difficulty is that blending changes the geometries of the blades so that they… more
Abstract:DESCRIPTION (provided by applicant): Skull base surgery is technically the most demanding of all of the neurosurgical procedures because of the intertwining of the hard, thick skull and delicate neural and vascular structures. A safer, quicker and more pre
cise way to remove the bony skull base will… more
Abstract:As processor clock speeds top out, software developers increasingly rely on concurrency, multicore, and distributed computing for performance goals -- and on platforms ranging from industrial controls to multicore desktops and scalable clouds. It is safe to speculate that errors in concurrent… more
Abstract:The goal of the proposed work is to create new ways to manage, visualize, and share data produced by multiple software analysis tools, and to create a framework for integrating diversely-sourced analysis tools into software practices, across the lifecycle, in a way that improves both reliability and… more
Abstract:DESCRIPTION (provided by applicant): The product that will result from the proposed STTR application from Sunstone Biosciences and the University of Pennsylvania is a novel labeled antibody-based reagent kit that can be used to rapidly identify diverse red
blood cell phenotypes prior to blood… more
Abstract:We propose to study development of a wireless network of seismic/acoustic/GPS sensors to carry out the ordnance-impact characterization. We propose to modify an existing design that includes a three-componenent seismograph (sampled at 10kHz), a microphone, and a high-precision GPS receiver. These… more
Abstract:Future software platforms starting with today's multicores will be massively parallel, offer unprecedented performance, and will be exceedingly difficult to program. In this project, we will work towards automatic development of high-performance software for these platforms. Specifically, we will… more
Abstract:DESCRIPTION (provided by applicant): Recently, scientists at Carnegie Mellon University (CMU) have invented a compelling technology that makes transplanted cells visible with magnetic resonance imaging (MRI). Cells of interest are labeled ex vivo with a n
ovel perfluoropolyether (PFPE) nanoemulsion… more
Abstract:TRS Technologies, Inc. proposes to develop ceramic capacitors as power conditioning capacitors for electrically driven military weapon systems. The proposed ceramic capacitor will combine some of the best features of high energy density, low dielectric loss, and high temperature stability. The… more
Abstract:Single crystal piezoelectric deformable mirrors with high actuator density, fine pitch, large stroke and no floating wires will be developed for future NASA science and communications applications. Single crystal piezoelectric DMs share the fine pitch with co-fired electrostrictive or ceramic… more
Abstract:Cryogenic fluid transfer components using single crystal piezoelectric actuators are proposed to enable low thermal mass, minimal heat leak, low power consumption and fast response for cryogenic fluid transfer and handling systems to support NASA Lunar Lander, Ground Operations, Ares, and Lunar… more
Abstract:High temperature piezoelectric crystal (HTP) sensors are desired for future propulsion component structure health monitoring, operating parameters optimization, turbine engine control and health monitoring, as well as improving performance and maintainability of power production facilities and other… more
Abstract:The proposed barium strontium titanate (BST) nanodielectric devices will combine some of the best features of bulk and thin-film based tunable dielectrics: low microwave losses, high tunability at high fields, the potential for low operating voltages, and less temperature dependent dielectric… more
Abstract:In this program TRS will explore a variety of new ferroelectric materials and composites for explosively driven pulsed power applications. The Phase I program will be aimed at demonstrating the feasibility of improving the FEG performance by: (a) systematically exploring new materials to enhance… more
Abstract:The objective of this program is to utilize single crystal piezoelectrics to develop a platform which contains both transmission and receiving for acoustic tracking ranges with the ability to operate at great depths undersea. The key aspects addressed in Phase I are 1) showing the performance of… more
Abstract:TRS Technologies, Inc. proposes to develop ceramic capacitors as discharge pulse power capacitors for high-power microwave (HPM) systems. The proposed ceramic capacitor will combine some of the best features of high energy density, low dielectric loss, fast discharge time and high temperature… more
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