Abstract:Piasecki Aircraft Corporation (PiAC) proposes to develop an innovative approach to substantially upgrade helicopter main rotor shaft designs, materials, and manufacturing processes. A number of design concepts will be addressed and a matrix of coating materials and application methods selected for… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research Phase II project will continue development of the Tube-Clear(TM) device to clear clogged and sluggish feeding tubes, satisfying a critical medical need and… more
Abstract:DESCRIPTION (provided by applicant): This Phase I NIH SBIR, will develop a Lightweight Electronically Controlled Transdermal Patch for Enfuvirtide Delivery (LET-PED). Thirty-three million people worldwide are living with the Human Immunodeficiency Virus (H
IV). Currently, patients infected with HIV… more
Abstract:DESCRIPTION (provided by applicant): In this Phase I NIH SBIR, Piezo Resonance Innovations will demonstrate feasibility of the Resonance Driven Vascular Entry Needle (RVEN), a device that facilitates successful venipuncture, particularly of veins that are
difficult and problematic to access due to… more
Abstract:DESCRIPTION (provided by applicant): In this Phase I NIH SBIR program, PRII will develop the Biopsy Force Reduction (BIFOR) Tool for adult patient Bone Marrow Biopsy. The BIFOR will reduce insertion force, improve biopsy sample quality and sampling rate s
uccess, and decrease patient discomfort and… more
Abstract:DESCRIPTION (provided by applicant): According to the American Cancer Society, approximately 1.3 million people are diagnosed with cancer each year, with the annual cost of treating cancer exceeding 60.9 billion. Mental health and psychosocial factors ass
ociated with cancer are poorly recognized… more
Abstract:The need for novel antibiotics is well understood by anyone familiar to the field. We have discovered a novel class of antibiotics that are structurally unique from all previously known antibiotics and appear to operate via a distinctive mode of action. As a result, these new agents appear to… more
Abstract:Multi-drug resistant (MDR) biofilms are perhaps the most difficult bacterial infections to fight. They require novel antibiotics that operate through new mechanisms which overcome the biofilm environment. We have discovered a class of antibiotics that are novel and have new targets which appear… more
Abstract:DESCRIPTION (provided by applicant): LMWHs are being used with greater frequency to treat deep vein thrombosis, unstable angina, and acute pulmonary embolism, as well as thromboprophylaxis agents in a wide range of clinical situations including orthopedic
surgery, high risk pregnancy, and cancer… more
Abstract:DESCRIPTION (provided by applicant): As the prominence of the ubiquitin and ubiquitin-like pathways increases, the need for assays to measure the activity of the enzymes involved in these pathways grows. Currently the only high throughput methods for meas
uring ubiquitin and ubiquitin-like… more
Abstract:The development of innovative sensor technologies requires a complete (both spectral and spatial) knowledge of missile hardbody and exhaust plume signature characteristics of current and evolving threat systems. However, measurement programs alone on domestic and foreign ballistic missiles cannot… more
Abstract:A physics-based method for computing the passive microwave spectrum emitted by rocket engine exhaust plumes is proposed. Microwave emissions have an advantage over infrared for early detection of missile and rocket launches due to their superiority in penetrating through clouds, dust, and fog. The… more
Abstract:DESCRIPTION (provided by applicant): Health care professionals who work with children have an especially difficult task when it comes to assessment of pain, particularly acute pain. Proper assessment of pediatric pain symptoms is needed not only for managi
ng symptoms, but also for determining… more
Abstract:To ensure mission success, astronauts must maintain a high level of performance even when work-rest schedules result in chronic sleep restriction and circadian misalignment, both of which contribute to fatigue and performance deficits unless effective countermeasures are used. We are proposing to… more
Abstract:Individual differences in vulnerability to sleep loss and fatigue from extended work hours and night work are a substantial problem in transportation work schedule development, fatigue risk management strategies, and prediction of performance impairment in real-world operations. This… more
Abstract:DESCRIPTION (provided by applicant): Q-Chem is a state-of-the-art commercial quantum chemistry program that is used to model molecular processes over a wide range of disciplines, including biology, chemistry, and materials science. Among all the quantum mo
dels, density-functional theory (DFT) is… more
Abstract:DESCRIPTION (provided by applicant): This Phase II proposal seeks support for completing implementation of effective fragment potential (EFP) method [J. Phys. Chem. A, v.105 p.293 (2001)] in the Q-Chem electronic structure program. The EFP approach enables
one to treat large systems with localized… more
Abstract:DESCRIPTION (provided by applicant): This Fast-Track application focuses on developing the first artificial intelligence (AI) educational software to teach developmental mathematics to the blind and visually impaired. This project responds to the National
Eye Institute's General Research Topics for… more
Abstract:This Small Business Innovation Research Phase II project will use readily available plant protein and innovative, environmentally friendly processes to develop bio-based plastic prototypes such as packaging products. The resulting formulation and production processes for each prototype will meet the… more
Abstract:The objective of this Phase I effort is to develop a new means of detecting undersea targets in the reverberation return as well as in the forward scatter zone. Previous tests regarding Forward Scatter Detection had not been able to establish acceptable False Alarm Rates (FAR), at a sufficiently… more
Abstract:A path planner is an integral part of any unmanned vehicle that is intended to autonomously navigate to a desired goal location. Although a great deal of research has been done in the field of path planning, there are still unsolved issues that require additional work. This project proposes several… more
Abstract:Military and Law Enforcement groups are increasingly relying on unmanned ground vehicles (UGVs) to perform life-threatening tasks such as urban reconnaissance operations in and around buildings and other structures. The seemingly simply task of having the UGV open doors and entering rooms is a… more
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