Abstract:As thermal management requirements aboard Navy platforms increase, conventional HVAC technology is becoming a liability in terms of mass, volume, and heat transfer capability. Future thermal demands will increase and the majority of this load will be handled by either the HVAC or chilled water… more
Abstract:Heat exchangers are often required to remove waste heat and cool vital components in industrial processes, automobiles, and commercial heating and cooling systems. The thermal efficiencies of these heat exchangers directly affect the overall energy efficiencies of these processes, and many aspects… more
Abstract:The Full Authority Digital Engine Control (FADEC) controls engine operation. It is historically mounted on the engine case to minimize the routing length of the sensor and actuator wiring. The FADEC must be maintained below 70oC, while the environment can be as hot as 170oC. The current design uses… more
Abstract:This Small Business Innovation Research Phase I research project aims to develop a wearable computer system with an innovative multimodal input mechanism. The objective of this research is to assess the feasibility, efficiency, and quality of documentation performed with a wearable computer… more
Abstract:This SBIR Phase I research proposal will develop nano-porous carbide-derived carbon electrodes for improved super-capacitor performance. The high power charge/discharge rate of current super-capacitors is offset by a low storage capacity compared to batteries. The capacitance of activated carbon… more
Abstract:This proposal presents a Phase I SBIR project to develop high-energy, high-power supercapacitor-battery hybrid energy storage systems. Batteries are widely used, but have limited power capability and cycle life. Supercapacitors, also called ultracapacitors or double-layer capacitors, are… more
Abstract:The Energy Policy Act (EPACT) of 2005 mandated that the U.S. Department of Energy (DOE) shall establish a ¿Next Generation Nuclear Plant¿ (NGNP) project. For this project, the DOE elected the Very High Temperature Reactor (VHTR) design as a concept that will demonstrate the production of both… more
Abstract:DESCRIPTION (provided by applicant): The product that will result from this SBIR program, proposed by Vironika and its consortium partner, The Wistar Institute, is a new (the first) small molecule drug candidate for Epstein-Barr virus (EBV) latent infectio
n, and its associated pathologies. EBV is a… more
Abstract:DESCRIPTION (provided by applicant): Derivatives of camptothecin (CPT) that inhibit Topoisomerase I (Top1) activity have demonstrated clinical utility in the treatment of various cancers. However, limitations in CPT pharmaceutical properties have driven th
e search for new CPT-like poisons that… more
Abstract:DESCRIPTION (provided by applicant): Severe shortages of donor organs limit the use of orthotopic liver transplantation (LT), the only proven therapy for end-stage liver diseases. Primary non-function (PNF) of liver grafts after transplantation typically r
esults in recipient death or necessitates… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project will develop and commercialize a novel Lithographic Gelcasting (LGC) manufacturing process for microdevices that is amenable for economical volume production. Molds will be made using photolithography and filled with nanoparticulate… more
Abstract:DESCRIPTION (provided by applicant): Fast and effective communication is the key to minimizing confusion, anxiety, and casualties both during and after a public health emergency. The ability of emergency services personnel to relay clear instructions, part
icularly to vulnerable populations, results… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research Phase I project will involve the development of a noninvasive intracranial pressure (ICP) monitor based on a pilot clinical study correlating ocular blood… more
Abstract:DESCRIPTION (provided by applicant): The product that will result from this proposal will be a potent biological regulator of innate immunity, 1- peptidyl-2,3-diacylglyceride (PDAG), for use in the prevention of hospital-acquired (nosocomial) infections i
n highly-susceptible patient populations.… more
Abstract:DESCRIPTION (provided by applicant): To reduce the incidence of pressure ulcers, administrators of long term care facilities must identify which care processes need improvement and measure if their management interventions are effective. Currently, this is
difficult because the reliability of care… more
Abstract:DESCRIPTION (provided by applicant): Sexual dysfunction is one of the most prevalent and persistent problems after cancer treatment. This Fast Track STTR will create and evaluate a multimedia educational and counseling tool to promote recovery of sexual sa
tisfaction in men treated for cancer.… more
Abstract:DESCRIPTION (provided by applicant): A Potential New Drug for Depression, an active SBIR Phase IIa award. The requested funds will allow additional characterization studies of three newly discovered mixed vasopressin 1a/1b antagonists, studies that were not part of the original application. These… more
Abstract:DESCRIPTION (provided by applicant): Hybrid Nanochannel Arrays for Single Molecule Linear Genome Analysis Abstract The objective of this proposal is to develop a fully integrated nanofluidic device for single molecule analysis of long, linearized, native s
tate genomic DNA. The project will result… more
Abstract:BDC is developing a process called SMART BLEND(TM) for inspecting blended IBRs/Blisks. IBRs are susceptible to foreign object damage and blending is a relatively low cost method using machining to repair that damage. The difficulty is that blending changes the geometries of the blades so that they… more
Abstract:DESCRIPTION (provided by applicant): Skull base surgery is technically the most demanding of all of the neurosurgical procedures because of the intertwining of the hard, thick skull and delicate neural and vascular structures. A safer, quicker and more pre
cise way to remove the bony skull base will… more
Abstract:As processor clock speeds top out, software developers increasingly rely on concurrency, multicore, and distributed computing for performance goals -- and on platforms ranging from industrial controls to multicore desktops and scalable clouds. It is safe to speculate that errors in concurrent… more
Abstract:The goal of the proposed work is to create new ways to manage, visualize, and share data produced by multiple software analysis tools, and to create a framework for integrating diversely-sourced analysis tools into software practices, across the lifecycle, in a way that improves both reliability and… more
Abstract:DESCRIPTION (provided by applicant): The product that will result from the proposed STTR application from Sunstone Biosciences and the University of Pennsylvania is a novel labeled antibody-based reagent kit that can be used to rapidly identify diverse red
blood cell phenotypes prior to blood… more
Abstract:We propose to study development of a wireless network of seismic/acoustic/GPS sensors to carry out the ordnance-impact characterization. We propose to modify an existing design that includes a three-componenent seismograph (sampled at 10kHz), a microphone, and a high-precision GPS receiver. These… more
Abstract:Future software platforms starting with today's multicores will be massively parallel, offer unprecedented performance, and will be exceedingly difficult to program. In this project, we will work towards automatic development of high-performance software for these platforms. Specifically, we will… more
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