Abstract:DESCRIPTION (provided by applicant): In vitro assays that reliably correlate with observed clinical DDI outcomes would facilitate drug development and reduce reliance on extensive animal testing. Immortal human in- testinal Caco-2 cells are widely used by
pharmaceutical companies to study drug… more
Abstract:Military simulations involving non-player characters (NPCs) representing non-US cultures are becoming increasingly important for training and mission rehearsal. However, creating culturally-realistic behaviors for these characters remains a technical challenge due to the lack of a clear standard or… more
Abstract:Cultural skills are increasingly important for military actions recently undertaken by the U.S., where close continuous contact with the indigenous population is necessary. All ground forces being deployed in culturally distinct and sensitive areas need to have at least some basics skills,… more
Abstract:Combat medics provide battlefield medical care under austere conditions and respond to traumas less frequently seen in civilian settings. CHI Systems, Inc. proposes to team with the Institute for Simulation and Training to address training for combat medics through the application of augmented… more
Abstract:Fully autonomous, taskable robots for use in unconstrained environments are still a dream rather than a reality because of a host of problems, including capabilities of existing sensors, effectors, and control/planning software. Indeed, concepts of operations for robot use are tending toward robots… more
Abstract:DESCRIPTION (provided by applicant): The long-term goal of this project is to create a sprayable surgical adhesive which would satisfy the surgical need for a strong, easy-to-use adhesive to adhere planar flaps of tissue. This novel adhesive will reduce fl
uid accumulation after surgery by… more
Abstract:The development of a trajectory envelope prediction tool, capable of identifying stores that may experience significant trajectory deviations due to unsteady loading is proposed. The Phase I part of this program will provide a comprehensive demonstration of the significance of these unsteady loads… more
Abstract:The JSF weapons bay experiences severe acoustic loading when exposed to the freestream. The severity and attenuation of this loading is exacerbated by the flight envelope of the JSF aircraft, as well as the requirement to carry and release "smart" weapons over an extended envelope. This extremely… more
Abstract:The innovation is that of using blast-based concepts for the hypersonic/endo dispense of an array of small hardened projectiles (SHAPs) from an interceptor missile. Hit-to-kill successes using this SHAP concept will be significantly enhanced from that of conventional, single warhead concepts, akin… more
Abstract:Intense dynamic and thermal loads will occur during stage-separation events that are of major concern from both operational and safety viewpoints. The insensitive-munitions (IM) stimuli and thermal/dynamic response associated with such events has received very little attention, yet this is of major… more
Abstract:This effort entails the validation of a RANS turbulent scalar transport model (SFM) for high speed propulsive flows, using new experimental data sets and accompanying large-eddy simulation (LES) solutions. The SFM has been used to predict local values of the turbulent Prandtl and Schmidt numbers and… more
Abstract:This proposal entails the development of specialized CFD models which can analyze transpiration cooling processes in complex high-speed environments. This is of significant importance to the Army since "well-designed" transpiration concepts are needed on missile systems that can provide reductions… more
Abstract:The overall goal of this STTR program is to develop an efficient, high-fidelity, CFD-based design tool for the simulation of ship-board flight testing of autonomous UAV systems. In Phase I, an overall flight simulation framework that employs a modular approach to the flight simulation problem was… more
Abstract:This program entails designing a Mach 10, scramjet propelled missile system using advanced CFD and design-optimization tools. The CFD codes were validated using full-scale data sets obtained from tests performed in the LENS shock tunnel facility. They contain advanced turbulence and thermochemical… more
Abstract:A new chemical kinetics model and database will be developed for aerothermodynamic analyses on entry vehicles. Unique features of this model include (1) the ability to model chemical kinetics in highly nonequilibrium flows at high altitudes, (2) the ability to predict nonequilibrium dissociation… more
Abstract:Propulsion systems may perform a variety of maneuvers during the ascent phase of flight that can impact the performance of an interceptor or other parts of an MDA system designed to perform threat detection, discrimination, and tracking. Our Phase I effort focuses on building on extending existing… more
Abstract:A unified comprehensive framework that incorporates Maxwell's equations coupled with the 3D unsteady Navier-Stokes equations of fluid mechanics, is being developed utilizing an innovative Multi-Physics Simulation (MPS) Architecture, for conducting multi-disciplinary simulations. The MPS Architecture… more
Abstract:The innovation proposed is the development of a high-fidelity software tool to be used for the design of hypersonic UAV dispense and subsequent dispense and dispersion of small hardened projectiles (SHAPs) from the UAVs using blast-based concepts. Such dispersed kinetic energy concepts can be… more
Abstract:A joint analytical/experimental program to develop technologies to improve thermal output from combustors in propulsion systems while ensuring their stable operation is proposed. The program will exploit the use of energetic materials as secondary fuels to be injected suitably into the combustors to… more
Abstract:The F-22A main weapons bay experiences severe acoustic loading when exposed to the freestream. The severity and attenuation of this loading is exacerbated by the flight envelope of the F-22A aircraft, as well as the requirement to carry and release "smart" weapons throughout this envelope. This… more
Abstract:Next generation liquid rocket systems envision novel designs for turbopumps that can operate at high suction speeds (i.e. low inlet pressures), and can be throttled over a wide range of low, off-design flow conditions. This is an extremely demanding flow regime where performance loss and damage… more
Abstract:Upgrades to a RANS Scalar fluctuation model (SFM) used to predict variations in turbulent Prandtl and Schmidt numbers in a scramjet combustor environment are proposed. Such upgrades will permit obtaining more accurate solutions leading to improved combustor designs. Experiments to be performed in… more
Abstract:Simulation technology plays an important role in propulsion test facility design and development by assessing risks, identifying failure modes and predicting anomalous behavior of critical systems. This is true for facilities such as the proposed A-3 that will operate at low pressures in conjunction… more
Abstract:In-space valves are required to provide precise mass flow control, wide throttling range and handle rapid on-off control. These requirements can result in significant unsteady, transient effects both on the fluid mass flow rate, as well as the torque required. However, there currently are no… more
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