Abstract:DESCRIPTION (provided by applicant): Breast cancer is the most frequently diagnosed type of cancer in women, with 1.3 million new diagnoses and 465,000 deaths annually worldwide. There is an acute need for improved prognostic and predictive tools to aid in
dividualized treatment for breast cancer.… more
Abstract:Heat pipes are widely used for passive, two-phase electronics cooling. As advanced high power, high performance electronics in space based and terrestrial applications produce ever increasing heat fluxes, heat pipes with improved thermal capacity are sought. Illuminex Corporation has demonstrated… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will prototype a novel photovoltaic (PV) material based on nanotechnology: photovoltaic fabric. The PV fabric will be woven using threads that… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research Phase I proposal will research, develop and demonstrate that the performance of Engineering Simulation and Modeling applications can be dramatically improved… more
Abstract:This Small Business Innovation Research Phase I project will address the problem of automating complex multi-step tasks and negotiations for computer users. The focus is on developing representations and algorithms for a personal assistant agent, and on contributing the incorporation of these… more
Abstract:DESCRIPTION (provided by applicant): Directxray Digital Imaging Technology (DXT) was formed in April of 2006, with a goal to introduce advanced technology developments for selenium detectors in x-ray imaging. We seek creative solutions to overcome the phys
ical limitations of existing selenium… more
Abstract:This project addresses two pressing problems in treating bacterial infections: the emerging resistance against current antibiotics and the role of biofilm formation in these infections. Based ona successful lead dendrimerthat acts against a broad spectrum of MDR pathogens including A.baumannii, and… more
Abstract:DESCRIPTION (provided by applicant): This is a Phase I proposal to develop a new family of imino sugars, with break through , unprecedented, potency, for the treatment of dengue virus (DENV) infection. There is currently no effective treatment for disease
s caused by this virus and both the public… more
Abstract:DESCRIPTION (provided by applicant): Novel Thioderivatives as Neuroprotective Anticonvulsants Abstract: The aim is to discover novel lead compounds that provide a disease- modifying therapeutic for the treatment of epilepsy. The ideal candidate molecules g
enerated by this program will exhibit both… more
Abstract:DESCRIPTION (provided by applicant): One sixth of the world's population has an infectious disease, and new agents involving novel mechanisms less likely to engender resistance are needed if for no other reason than the almost certain emergence of mutant s
trains and new pathogens in the future.… more
Abstract:This Small Business Innovation Research Phase I research project proposes to develop a smart wheelchair system that will integrate onboard LIDAR for position estimation and obstacle detection with an adaptive motor controller framework. The resulting smart-chair will be capable of autonomous… more
Abstract:The number of female farmers in the U.S. is on the rise, indicating a need for agricultural equipment that is safe and easy to use for women. Between 1997 and 2002, the total number of U.S. farms declined by almost 4%, yet the number of farms whose principal operators were women increased by 13%.… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project seeks to investigate the feasibility of a novel molten substrate fabricated from high-density liquids of metals/alloys and slags for producing high solar quality crystalline silicon wafer. In this innovative design a molten support… more
Abstract:There has been a great deal of development effort within the academic, governmental, and commercial arenas over the past few years in the field of information extraction. Based on our investigation, however, it appears that there is no ground truth for SIGACTS reports, which prevents GMTI users,… more
Abstract:DESCRIPTION (provided by applicant): Botulinum toxin is a potential bioweapon that can be used in acts of bioterrorism or biological warfare. Although the toxin is extraordinarily potent, there is little likelihood that there will be universal vaccination
of the public. This can be attributed to… more
Abstract:DESCRIPTION (provided by applicant): Most current chemotherapeutics are untargeted formulations that have little to no selectivity for cancerous tissue. As a result, these drugs often cause damage to healthy tissues which leads to uncomfortable and at time
s intolerable dose-limiting toxic side… more
Abstract:DESCRIPTION (provided by applicant): This project is designed to research and develop means for the early detection of impending roof falls in underground mines and means for alerting maintenance crews to take proactive action to prevent disaster, thereby
saving lives and preventing injuries to… more
Abstract:The objective of this proposal is to demonstrate the feasibility of an innovative thin-multilayer setback piezoelectric generator (TM-SPG) to provide inertial harvested power for spin stabilized small-and-medium-caliber fuzing. The novel setback generator uses the characteristics of piezoelectric… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project proposes biologically inspired polymer fibrillar adhesives as new gripping materials for ultragrip sports glove and other potential gripping and… more
Abstract:NanoGriptech LLC proposes to develop repeatable skin adhesives using technology inspired by the feet of geckos and insects. These adhesives will be integrated into full facemask respirators to reduce or replace head harness straps, which are currently used to hold the facemasks in place. Expected… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will result in the first hand-held, non-invasive device for measuring pressure within the head and brain. The proposed device will be a simple sensor that can be placed against the skin and that will determine brain pressure from the… more
Abstract:DESCRIPTION (provided by applicant): We aim to commercialize a new technology to rapidly sequence DNA. This technology can be applied (with proper preprocessing steps) to whole genome sequencing, and other assays including transcriptomics, transcription f
actor activity, miRNA expression, DNA… more
Abstract:DESCRIPTION (provided by applicant): As the primary mechanism by which animals detect nutrient-rich foods and discriminate against toxins, the sense of taste has a significant impact on health and behavior. Bitter tastes are perceived with high sensitivity
and broad specificity, and can evoke… more
Abstract:Hard chromium coatings (0.25 to10 mil thick) are used extensively for imparting wear and erosion resistance to components in both industrial and military applications. The most common means of depositing hard chromium has been through the use of chromic acid baths containing hexavalent chromium… more
Abstract:This proposal seeks to investigate the use of a novel high strength nanostructured metal (NanovateTM) as a thin structural reinforcing shell on ultra-lightweight carbon fiber reinforced plastic (CFRP) propellant and cryogenic storage tanks. In the proposed project, Integran seeks to… more
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