Abstract:The primary objective of this Phase II is to develop more complete part class coverage for the ADEC system. During Phase I, Nokomis demonstrated ADEC"s authentication capabilities. ADEC detects counterfeits through automated analysis of unintended radiated emissions that are characteristic of… more
Abstract:National Aeronautical and Space Administration's (NASA) Aviation Safety Program "seeks capabilities furthering the practice of proactive safety management." Specifically, one of the key interests in Topic A1.04 are proposals for Remaining Useful Life prediction techniques. In… more
Abstract:The design concepts being considered for Heatshield for Extreme Entry Environment Technology (HEEET) rely on the use of 3D woven carbon fiber preforms. Therefore, there is a need to be able to predict the properties and performance of a woven material. Validation of predictive modeling tools would… more
Abstract:As the power density of advanced engines increases, the need for new materials that are capable of higher operating temperatures, such as ceramic matrix composites (CMCs), is critical for turbine hot-section static and rotating components. Such advanced materials have demonstrated the promise to… more
Abstract:The Climate Change Information System for Business and Industry (Climate Biz) will translate information derived from climate model simulations into industry-specific formats that will assist private sector executives and their firms to meet the challenge of climate change and thereby prosper in the… more
Abstract:DESCRIPTION (provided by applicant): Optofluidics Inc. proposes to develop a near field optical chromatograph, the BioPrism, and apply it to the characterization of particle coating stability in nanomedicine. According to clinicaltrials.gov, about 10% of all clinical trials involv nanoparticles and… more
Abstract:This SBIR Phase I project proposes to develop and commercialize an online video-sharing platform that scales math teacher education and training. The platform embeds a novel pedagogical method that combines gamification, algorithm-based peer review processes, and social learning technologies. The… more
Abstract:DESCRIPTION (provided by applicant): Lyme disease (LD) is the most commonly reported tick-borne illness in the United States. According to the recent Center for Disease Control and Prevention report, approximately 300,000 Lyme cases are diagnosed each year. If left untreated, the infection spreads… more
Abstract:DESCRIPTION (provided by applicant): Adenosine to inosine or A-to-I RNA editing executed by ADAR family proteins is abundant in the central nervous system (CNS). The availability of tools to monitor and manipulate both ADAR enzymes and A-to-I RNA modifications will facilitate investigation of the… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal antibodies are used for treatment of a wide range of diseases from cancer to infectious diseases. However, development of antibodies with high affinity and specificity is still time-consuming, labor-intensiveand unpredictable. Abzyme Therapeutics LLC… more
Abstract:DESCRIPTION (provided by applicant): Broad-spectrum, orally bioavailable -lactam antibiotics play a critical role in the management of human infectious diseases, both in the hospital and community settings, facilitating exit from the ICU and treatment inthe general ward, early discharge and/or… more
Abstract:Abstract: This is a Phase II application for continued development of the Chemalytics Platform, a scalable computational infrastructure to enable virtual screening of chemical libraries using the Amazon EC2 cloud computing environment and automated dockingtools. Structure-based virtual screening is… more
Abstract:DESCRIPTION (provided by applicant): AMPA glutamate receptors mediate the majority of fast excitatory neurotransmission in the central nervous system. Four AMPA receptor subunits exist, GluA1-GluA4, with functional channels containing various combinationsof these four subunits. Dysregulation of AMPA… more
Abstract:DESCRIPTION (provided by applicant): Exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions including the detonation of dirty bombs is a significant public health concern. The lung is particularly susceptible to ionizing radiation injury from external… more
Abstract:DESCRIPTION (provided by applicant): Respiratory distress syndrome (RDS) is an acute, severe pulmonary disorder that is the leading cause of morbidity and mortality in preterm infants. It is a major healthcare concern - costs associated with treatment of RDS and its complications exceed 2.4 billion… more
Abstract:We propose a rapid mapping and 3-D visualization system especially suited for inside buildings, tunnels, urban"canyons", and other environments where GPS may be poor or not available. The system--which was fully demonstrated in our Phase I effort-- includes mobile Sensor Nodes that… more
Abstract:Although global pose is essential for success in certain vehicle missions and tasks, when GPS is denied there is no single technology (source) that can robustly estimate global pose without suffering from one or more failure modes. We propose to design an architecture that provides robustness by… more
Abstract:Project Summary/Abstract This SBIR grant funds efforts to perfect and scale up a newly patented process for fabricating ultrasharp and hard probe tips for making images of biological specimens. Scanning probe microscopy (SPM) methods such as atomic force microscopy (AFM) create images of surfaces by… more
Abstract:DESCRIPTION (provided by applicant): The goal of this research is to develop a new flow cytometry-based test for the clinical measurement of proangiogenic T cells. Such an assay does not exist today. Proangiogenic T cells, including angiogenic T cell (Tang) and Th17 subsets, participate in… more
Abstract:Radio frequency (RF) technology is a key technology common to all high energy accelerators. RF sources with improved efficiency and accelerating structures with increased accelerating gradient are important for keeping the cost down for future machines. Energy storage components represent a… more
Abstract:This project will develop high performance capacitor film and film capacitor manufacturing technologies to achieve high energy density in large-size, high-voltage sub-microsecond discharging pulsed power capacitors. The capacitor will be able to withstand DC voltage for over 3,000 hours and deliver… more
Abstract:The project will develop high performance three-phase polymer nanocomposite compositions with significantly improved waterproof capability, while still maintaining excellent mechanical and acoustic properties. The towed array hose can be produced using existing manufacturing process and low-cost… more
Abstract:We propose to develop a multi-functional coating technology using a three-component nanocomposites to achieve excellent syperhydrophobicity, anti-icing, enhanced track-resistance, and high dielectric breakdown strenght. The coating will be compatible with current Navy existing VLF device materials… more
Abstract:This project will develop advanced DC link capacitors using flexible ultrathin glass dielectric materials. The glass capacitor will be able to be operated in a broad temperature range (-150 degree C to 500 degree C), frequency (1 kHz to 1 MHz), and high voltage (>1,000 volts). This SBIR project… more
Abstract:This SBIR Phase I project will develop a multifunctional electrolyte for high energy density abuse-tolerant lithium ion batteries with 5 V cathodes such as LiCoPO4. The multifunctional electrolyte comprises of a non-flammable ionic liquid as solvent and a porous ionomer membrane which serve as both… more
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