Abstract:A vaccine to protect against diseases resulting from infection with Streptococcus pyogenes is under development. This vaccine utilizes a recombinant fusion protein (SpeAB) comprising of genetically detoxified SpeA, a secreted toxin, and SpeB, a surface bound and secreted cysteine protease. During… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop and commercialize an active driving aid that enables semi-autonomous, cooperative navigation of an electric-powered wheelchair (EPW) both indoors and in dynamic, outdoor environments. It uses intelligent sensing and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will demonstrate and develop technology for the roll-to-roll production of continuous graphene films. The graphene production technology is based upon innovations in the graphene synthesis and graphene handling, addressing critical… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerotic disease is a prevalent and progressive condition that can be difficult to assess during sub- clinical stages. A developing and exciting biomarker strategy is the measurement of microparticles (MPs) and assessment of circulating progenitor and… more
Abstract:QorTek and Lockheed Martin Mission Systems and Sensors (LM MS2) are together proposing a new advanced integrated topology converter architecture that would significantly improve both low frequency rejection, the high frequency switching noise content and still fit within the confines of the design… more
Abstract:ABSTRACT: Advantages of health management algorithms to critical and complex systems are numerous. For example, a health management system can improve system readiness by quantifying the health of the system and reduce maintenance costs. By applying these methodologies to unmanned vehicle… more
Abstract:In this SBIR Phase II project, we propose to develop high energy density film capacitors by using our high performance polymer dielectric compositions, low-cost capacitor production process, and robust capacitor design guided by modeling. It is expected that prototype wound capacitor with energy… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop advanced single ion gel electrolytes and related low cost manufacturing process for high power rechargeable lithium ion batteries (LIBs) with enhanced safety. Current LIB electrolytes consist of liquid organic solvents and… more
Abstract:Voci Technologies Incorporated (Voci) is the leading small business developing accelerated Human Language Technology based solutions. In Phase I of this SBIR, Voci demonstrated the feasibility of automatically clustering audio with useful false-positive and false-negative rates. In Phase II, Voci is… more
Abstract:Voci Technologies Incorporated (Voci) is partnering with Carnegie Mellon University (CMU) to develop and demonstrate a prototype Automated Spoken Language Recognition System (ASLRS). The ASLRS is specifically designed to enhance the usability of Speech to Speech (S2S) Machine Foreign Language… more
Abstract:The web has experienced a huge increase in the amount of content published daily, forcing users to cope with information overload. This challenge,however, is not limited to just web content. More recently, an explosion in social content and social connections on the web have lead to a new challenge:… more
Abstract:The objective of ONR SBIR Solicitation Topic N112-159, Auxiliary System Sensor Fusion, is to develop methods and algorithms that allow sensor information from disparate auxiliary systems to be intelligently fused to provide enhanced situational awareness. A Phase II proposal in response to the… more
Abstract:The US aquaculture industry, which is around a $2B per year business consisting of 6,343 businesses that employ 15,198 people is greatly in need of a non-toxic and long-lasting antifouling coating. Biofouling is the undesirable accumulation of microorganisms, plants, and animals on man-made surfaces… more
Abstract:Under this topic we seek to develop methods for micro-air vehicles (MAV) to determine their position in global coordinates when Global Positioning System (GPS) is unavailable in environments such as when operating inside structures. One specific application is to assist in reconnaissance to aid in… more
Abstract:Intellectual Merit This Small Business Innovation Research Phase I project takes a novel approach to produce improved maize cultivars for bioenergy applications. Lignin in cellulosic biomass creates a barrier that limits conversion of cellulose into biofuels. In the proposed approach, the lignin in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project objective is to evaluate the technical feasibility of a hand-held, point-of-care instrument for the detection of early-stage pressure ulcers. Pressure ulcers (PUS) are a common healthcare problem that affects approximately 2.3 million… more
Abstract:DESCRIPTION (provided by applicant): Targeted Therapeutic Solutions (TTS, a small business) is developing a first-in-class thromboprophylactic agent (TTS01) for use in the hospital setting having a rapid onset of action to dissolve clots and prevent the formation of new clots with a reduced risk of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project develops a novel surgical closure system for closing internal incisions in endoscopy. The initial application is closing the vaginal cuff in laparoscopic hysterectomy. Sutures are typically used to close internal incisions in… more
Abstract:DESCRIPTION (provided by applicant): Development of a urine test for the early detection of liver cancer. The need to develop an effective method of detecting hepatocellular carcinoma (HCC) is urgent. HCC is the third leading cause of cancer deaths and hasa 5-year survival rate of less than 15%. If… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop novel high energy/power density polymer based cathode material for Li-ion battery. There is great demand for inexpensive, lightweight, and environmentally friendly Li-ion batteries for emerging applications such as… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop innovative baby food products with optimized nutritional value. The research objective is to establish optimized processing methods through mechanics-based approaches to enhance nutrient bioavailability and… more
Abstract:Elevated levels of human butyrylcholinesterase (BuChE) confer protection from chemical warfare nerve agents and other organophosphorous chemicals. As a prophylactic, the key to enabling this protection is the ability to maintain elevated concentrations of BuChE in the plasma for days or weeks. … more
Abstract:DESCRIPTION (provided by applicant): Controlled release formulations can improve patient adherence and drug safety or even enable new types of basic medical research. The key to realizing these benefits is the ability to design and produce these formulations in a cost-effectiv and timely manner.… more
Abstract:While unmanned air vehicles are starting to operate in complex urban and indoor environments, many challenges still remain. Our proposed project will address three key challenges through the development of algorithms. First, we reduce operator workload in the operation of autonomous vehicles in GPS… more
Abstract:This Small Business Innovation Research Program (SBIR) Phase I project will develop a "Fiber-loop Cavity Ring-down spectrometer" to address the critical need for an in situ means to measure contaminants in cryogenic liquids. Lacking a way to measure impurities in the liquid phase,… more
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