Abstract:DESCRIPTION (provided by applicant): Genetic alterations that maintain cells in a poorly differentiated state are a hallmark of many leukemia and childhood cancers. Among them, neural crest-derived neuroblastoma is the most prevalent cancer in infants andthe most common extracranial solid tumor in… more
Abstract:DESCRIPTION (provided by applicant): Extreme reactions to food results in over 30,000 incidents of anaphylaxis and between 100 - 200 deaths in the US each year. Allergies to tree nuts (TN), such as almond, cashew, hazelnut and walnut, are collectively thesecond most common triggers of anaphylaxis… more
Abstract:Phase 2 involves the continued development of the F-MIRE FAES system. The FAES system insertion loss measurements utilize a sub-miniature MEMS microphone mounted in the ear canal of the HPD wearer. An ultra-thin flat flexible cable connects the microphone to a signal conditioning unit and power… more
Abstract:DESCRIPTION (provided by applicant): Decreasing readmissions through better discharge planning (DP) and transitional care is a national healthcare priority. RightCare Solutions has leveraged over 10 years of interdisciplinary academic research led by a nurse researcher, and through our highly… more
Abstract:Our aim in this project is to apply the state-of-the-art in science autonomy, including the PI's recent work at Carnegie Mellon in areas of automatic spectrometer targeting and spectra collection, science-guided path planning, and orbital terrain classification, to the creation of Intelligent… more
Abstract:Robots need to know their location to map of their surroundings but without global positioning data they need a map to identify their surroundings and estimate their location. Simultaneous localization and mapping (SLAM) solves these dual problems at once. SLAM does not depend on any kind of… more
Abstract:DESCRIPTION (provided by applicant): The goals of this project are to develop a biomarker for MLR-1023 in order to validate Lyn kinase as a molecular target for treatment of Type II diabetes (T2D) and use the biomarker to understand the pharmacokinetic/pharmacodynamic (PK/PD) disconnect in order to… more
Abstract:Abstract As anyone who has had an eye injury, or even a small foreign object in the eye, knows-the cornea and surrounding structures are exquisitely sensitive to physical trauma. Ocular pain can be agonizing, paralyzing and extremely distressing to both the affected person, and particularly in the… more
Abstract:DESCRIPTION (provided by applicant): Clostridium difficile (CD) is a bacterium causing diarrhea and other intestinal problems linked to 14,000 annual deaths in the US. CDI is an antibiotic-associated infection as well as a health-care-associated infection.Current CDI diagnosis relies on CD toxins… more
Abstract:Environmental Fuel Research, LLC, proposes to commercialize a grease trap waste to biofuel process based on process research from Drexel University. Grease trap waste is dirty and low-value material produced by the food service industry that is high in lipids that can be converted to biodiesel. The… more
Abstract:The objective of the proposed program is to use advance manufacturing processes, to form near-net shaped (NNS) titanium wheeled hubs for tactical vehicles. Three manufacturing routes will be investigated including casting and two powder metallurgy processes based on Summit Materials Shaped Hot… more
Abstract:Disparities in healthcare delivery and outcomes have been linked, in part, to the difficulties physicians have in establishing effective communication with patients who differ from themselves in terms of race, ethnicity and economic circumstances. Diabetesmellitus and pre-diabetic nutrition-based… more
Abstract:Achieving robust autonomy by demonstration is challenging for several reasons. First, it is important to be able to provide demonstrations in a way that they capture the key aspects of robot interaction with environment. Second, the interface for providing demonstrations needs to be friendly enough… more
Abstract:High performance steels were developed in a cooperative program between the Federal Highway Administration (FHA), the American Iron and Steel Institute (AISI), and the U.S. Navy Carderock Division of the Naval Surface Warfare Center. HPS70W high strength steel is currently being used in bridge… more
Abstract:Project Abstract for the general public This Small Business Innovation Research (SBIR) Phase I project is motivated by fundamental questions about the way drug molecules are processed in the human body. Drug candidates cannot address a human disease unless they reach the appropriate sites within the… more
Abstract:Prescription drug overdose has become a significant source of preventable mortality and health care utilization in the United States. Public policies are now being deployed to influence the problem at every stage from access to opioid medicines to innovative strategies for managing overdose after it… more
Abstract:The project team is developing a prototype of the LightSide Revision Assistant, a web-based writing program for students in grades 6 to 8. The product will include an interface where students write essays and receive instant and automatic feedback, including in-line comments. Feedback will support… more
Abstract:Biofuels from agricultural sources is one component of the strategy for achieving energy independence. Specifically, bio-butanol is a more attractive fuel than bio-ethanol because it:provides better gas mileage;achieves higher blends with gasoline than bioethanol;runs in existing engines;has greater… more
Abstract:DESCRIPTION (provided by applicant): Hospital re-admission can be devastating for patients and carries significant financial burdens for health care systems. In 2013, the recently implemented Medicare Hospital Readmissions Reduction Program imposed 227 million in penalties on 2,225 hospitals.… more
Abstract:Traditionally, live system testing has been by far the primary source of evidence of the safety of an autonomous vehicle. Live testing also plays a prominent role in demonstrating the safety of drive-by-wire and driver-safety technologies in the autom
Abstract:ABSTRACT: Carbon fiber reinforcements pre-impregnated with resin (prepregs) are growing as a base material for many aerospace products. As such, prepreg quality is ever important and a key quality metric is its level of impregnation (LOI). However, high tolerance of prepreg LOI is difficult for… more
Abstract:ABSTRACT: The objective of the work proposed herein is to develop innovative physics-based models facilitating the accurate prediction of solid rocket propellant behavior with varying environmental boundary conditions. Our objective is to design and develop a theoretical framework for the… more
Abstract:Currently there is no tactical decision aid (TDA) for magnetic anomaly detection (MAD). Since the P-8A has no MAD capability, the planned approach to the localization phase of anti-submarine warfare (ASW) is to have the P-8A launch a MAD-equipped unmanned aerial vehicle (UAV). However, the mission… more
Abstract:This small business innovation Phase I project aims to develop a robust architecture for an attention based visual system for autonomous vehicle applications. Such a system is a critical front-end component for highly cognitive systems that can recognize objects and extract scene semantics from high… more
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