Abstract:DESCRIPTION (provided by applicant): Multi-drug resistance in Enterobacteriaceae is regarded as a healthcare crisis. This crisis has been further amplified by the recent emergence of the NDM-1 super-bug gene , a zinc-based metallo- -lactamase (Amber Class B), in Enterobacteriaceae. Members of… more
Abstract:DESCRIPTION (provided by applicant): This Phase I SBIR develops and tests the active Pedi ET-Clear system to clean mucus from 2.5 mm diameter neonatal endotracheal tubes with significantly reduced deleterious impact on lung function and mechanics, as compared to current methods. Actuated Medical,… more
Abstract:DESCRIPTION (provided by applicant): In this Phase II SBIR, Actuated Medical, Inc. will complete the development of the Actuated Low-Force Biopsy Tool for Versatile Bone Lesion Access with Less Trauma. Public Health Problem: Percutaneous bone biopsy is performed to obtain tissue for specific… more
Abstract:DESCRIPTION (provided by applicant): In this Phase II NIH SBIR, Actuated Medical, Inc. will complete the development of the Pedi-GJ-ClearTM device for clearing occlusions and restoring patency in-situ to pediatric gastrojejunal feeding tubes (GJ-tubes) - eliminating the need to surgically replace… more
Abstract:This project develops the "Active Needle Technology System (ANTS) for Cattle to Reduce Insertion Force, Reduce Pain, Facilitate Vascular Access, and Reduce Meat Loss from Injection Scarring". This project meets Strategic Goal 3: Help America Promote Agricultural Production And… more
Abstract:DESCRIPTION (provided by applicant): Organophosphate (OP) nerve agents have been deployed as weapons of mass destruction in warfare arenas and in recent terrorist attacks; posing significant risks to military personnel, civilians, first responders and healthcare provider. The classic OP nerve agents… more
Abstract:A vaccine to protect against diseases resulting from infection with Streptococcus pyogenes is under development. This vaccine utilizes a recombinant fusion protein (SpeAB) comprising of genetically detoxified SpeA, a secreted toxin, and SpeB, a surface bound and secreted cysteine protease. During… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project proposes to develop and commercialize an active driving aid that enables semi-autonomous, cooperative navigation of an electric-powered wheelchair (EPW) both indoors and in dynamic, outdoor environments. It uses intelligent sensing and… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will demonstrate and develop technology for the roll-to-roll production of continuous graphene films. The graphene production technology is based upon innovations in the graphene synthesis and graphene handling, addressing critical… more
Abstract:DESCRIPTION (provided by applicant): Atherosclerotic disease is a prevalent and progressive condition that can be difficult to assess during sub- clinical stages. A developing and exciting biomarker strategy is the measurement of microparticles (MPs) and assessment of circulating progenitor and… more
Abstract:QorTek and Lockheed Martin Mission Systems and Sensors (LM MS2) are together proposing a new advanced integrated topology converter architecture that would significantly improve both low frequency rejection, the high frequency switching noise content and still fit within the confines of the design… more
Abstract:ABSTRACT: Advantages of health management algorithms to critical and complex systems are numerous. For example, a health management system can improve system readiness by quantifying the health of the system and reduce maintenance costs. By applying these methodologies to unmanned vehicle… more
Abstract:In this SBIR Phase II project, we propose to develop high energy density film capacitors by using our high performance polymer dielectric compositions, low-cost capacitor production process, and robust capacitor design guided by modeling. It is expected that prototype wound capacitor with energy… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop advanced single ion gel electrolytes and related low cost manufacturing process for high power rechargeable lithium ion batteries (LIBs) with enhanced safety. Current LIB electrolytes consist of liquid organic solvents and… more
Abstract:Voci Technologies Incorporated (Voci) is the leading small business developing accelerated Human Language Technology based solutions. In Phase I of this SBIR, Voci demonstrated the feasibility of automatically clustering audio with useful false-positive and false-negative rates. In Phase II, Voci is… more
Abstract:Voci Technologies Incorporated (Voci) is partnering with Carnegie Mellon University (CMU) to develop and demonstrate a prototype Automated Spoken Language Recognition System (ASLRS). The ASLRS is specifically designed to enhance the usability of Speech to Speech (S2S) Machine Foreign Language… more
Abstract:The web has experienced a huge increase in the amount of content published daily, forcing users to cope with information overload. This challenge,however, is not limited to just web content. More recently, an explosion in social content and social connections on the web have lead to a new challenge:… more
Abstract:The objective of ONR SBIR Solicitation Topic N112-159, Auxiliary System Sensor Fusion, is to develop methods and algorithms that allow sensor information from disparate auxiliary systems to be intelligently fused to provide enhanced situational awareness. A Phase II proposal in response to the… more
Abstract:The US aquaculture industry, which is around a $2B per year business consisting of 6,343 businesses that employ 15,198 people is greatly in need of a non-toxic and long-lasting antifouling coating. Biofouling is the undesirable accumulation of microorganisms, plants, and animals on man-made surfaces… more
Abstract:Under this topic we seek to develop methods for micro-air vehicles (MAV) to determine their position in global coordinates when Global Positioning System (GPS) is unavailable in environments such as when operating inside structures. One specific application is to assist in reconnaissance to aid in… more
Abstract:Intellectual Merit This Small Business Innovation Research Phase I project takes a novel approach to produce improved maize cultivars for bioenergy applications. Lignin in cellulosic biomass creates a barrier that limits conversion of cellulose into biofuels. In the proposed approach, the lignin in… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project objective is to evaluate the technical feasibility of a hand-held, point-of-care instrument for the detection of early-stage pressure ulcers. Pressure ulcers (PUS) are a common healthcare problem that affects approximately 2.3 million… more
Abstract:DESCRIPTION (provided by applicant): Targeted Therapeutic Solutions (TTS, a small business) is developing a first-in-class thromboprophylactic agent (TTS01) for use in the hospital setting having a rapid onset of action to dissolve clots and prevent the formation of new clots with a reduced risk of… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project develops a novel surgical closure system for closing internal incisions in endoscopy. The initial application is closing the vaginal cuff in laparoscopic hysterectomy. Sutures are typically used to close internal incisions in… more
Abstract:DESCRIPTION (provided by applicant): Development of a urine test for the early detection of liver cancer. The need to develop an effective method of detecting hepatocellular carcinoma (HCC) is urgent. HCC is the third leading cause of cancer deaths and hasa 5-year survival rate of less than 15%. If… more
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