Abstract:DESCRIPTION (provided by applicant): Microscopic analysis of tissue mounted on glass slides is commonly used to study cancer, non-neoplastic entities such as heart disease and diabetes, and normal cell function. Researchers utilize micro and macro tissue dissection techniques in order to recover… more
Abstract:This Small Business Innovation Research Phase I project assesses the feasibility of using a novel synergistic drug-polymer ocular film product based on a modified biopolymer hydrogel to deliver antibiotics directly, locally and continuously to the ocular surface over an extended weekly period. This… more
Abstract:Energy storage devices in many aerospace applications are facing unique challenges. Most of such applications, including remote surveillance, satellites, reusable launch vehicles, etc. depend on high-performance, highly specialized batteries. NASA desires high specific energy batteries that are safe… more
Abstract:This Small Business Innovation Research Phase I project describes development of a manufacturing method for production of large-scale, consistently high-quality and low-cost semiconductor nanocrystals, such as quantum dots. The unique size- and shape-related properties of these materials make them… more
Abstract:This Small Business Innovation Program (SBIR) Phase I project commercializes a technology that reduces the energy consumption in digital electronics on average by a factor of three. The solution applies across the complete semiconductor marketplace. The power advantages are derived based on… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project addresses this problem: with the explosion of data and apps, it is ever harder to find information in context. How can information be found if it was lost or not captured in the first place? The proposed solution enables to 'capture… more
Abstract:This Small Business Innovation Research Phase I project will develop a new and improved sensor material to detect the vapors of peroxide-based homemade explosives. The Department of Homeland Security and Department of Defense have identified peroxide-based homemade explosive detection as a top… more
Abstract:DESCRIPTION (provided by applicant): In the last two decades though the field of neuroprosthetics has gained tremendous momentum through the development of novel architectures for neural interfaces, however, till date there is no device which can be nomenclatured as the gold standard in the field.… more
Abstract:DESCRIPTION (provided by applicant): In order to successfully use microelectrode arrays for stimulation in chronic implantation, the neural electrode must have longevity and efficacy. Efficacy of stimulation primarily means injecting enough charge to the targeted tissue to elicit action potentials.… more
Abstract:This Small Business Technology Transfer (STTR) Phase I Project aims to optimize and test prototypes of continuous, multi-analyte sensors based on stimuli-responsive hydrogels. The proposed sensor array will be capable of monitoring multiple biomarkers relevant to several common human diseases such… more
Abstract:Espira has developed a Biohazard Water Analyzer (BWA) for field-based rapid pathogen detection. BWA employs advanced technologies including microfluidic sample preparation for nucleotide analysis and highly sensitive carbon nanotube-based electrochemical sensing for rapid detection of indicator… more
Abstract:Existing building stock represents a significant opportunity for energy savings through efficiency measures, as it accounts for 41% of US energy use. Advanced control strategies and better systems commissioning offer the least expensive routes to energy savings by utilizing existing building… more
Abstract:Critical to determining the success of an EGS well is the measurement of the flow distribution along the open-hole length of that well. Knowledge of not only the depth but the spacing of intersected fractures is required in order to determine the sweep efficiency of fluids flowing through the… more
Abstract:DESCRIPTION (provided by APPLICANT): Medical errors are recognized as the cause of numerous deaths, and even if some are difficult to avoid, many are preventable. Computerized physician order-entry systems with decision support have been proposed to reducethis risk of medication errors, but these… more
Abstract:DESCRIPTION (provided by applicant): Accurate measurement of core body temperature during surgery as well as in critical care is imperative to a positive outcome and ongoing quality of life for patients. Core temperature management of patients during extended anesthesia such as cardio-pulmonary… more
Abstract:NASA has numerous missions that involve radar and radiometry. In the past, the practice has been to build each system as a one-off program, which makes MMIC design unattractive from a cost perspective. In an era of reduced budgets and the need for higher efficiencies both in R & D cost reduction… more
Abstract:The synthesis of ammonia through nitrogen fixation is a vital component to all plant life and the world economy as a fertilizer and commodity chemical. The global industial production of ammonia exceeded 140MM tons in 2009 and is expected to grow to 160MM tons by 2020. Most ammonia,>90% is… more
Abstract:This Small Business Technology Transfer (STTR) Phase I project is to develop an inexpensive and rapid sensing technology for detection of tuberculosis (TB) at the point of care (POC). Rapid screening of TB in rural areas is difficult because current diagnostic methods are expensive, time consuming… more
Abstract:This Small Business Innovation Research Phase II project will demonstrate techno-economic feasibility of a novel bioprocess to produce fatty acids from lignocellulosic biomass leading to commercialization. These fatty acids are primary components of several consumer products such as skincare,… more
Abstract:DESCRIPTION (provided by applicant): Schizophrenia is a complex psychiatric disorder with a heterogeneous clinical phenotype. It is probably one of the most costly psychiatric illnesses, yet the development of novel and safe antipsychotics lags behind. Amplifying the actions of endocannabinoids by… more
Abstract:DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not… more
Abstract:The US Department of Energy has a stated goal to increase the energy efficiency of turbines, and one well recognized method of achieving this is through the use of ceramic thermal barrier coatings (TBCs). However, state of the art zirconia-based TBCs have a temperature limit of about 1200oC, and new… more
Abstract:The proposed research will look at a combination of low-cost radar, stereo camera, and lidar data to generate a 3D model of the terrain ahead of a vehicle. The resulting terrain model will be automatically segmented, simplified and compressed to produce a reasonable description, which can interact… more
Abstract:Environmental Benefits: The proposed technology relates to Climate change and sustainable energy. Fatty acids are currently produced from palm oil, 80% of which comes from Malaysia and Indonesia. Both these countries have finite land available and often times rainforests are destroyed to make way… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to further develop ATX-Red, an in vivo imaging agent that becomes fluorescent in the presence of the enzyme autotaxin. Autotaxin and its product LPA are involved in numerous biological functions that generally involve cell movement… more
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