Abstract:DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming norma
l bone marrow cells, but until now has not… more
Abstract:The overall objective of the proposal is to design, develop and demonstrate a potentially portable Compton x-ray scatter 3D-imaging system by using specially designed rotationally movable x-ray source and x-ray detector, and the development of a suitable 3D-processing computer model.
The proposed… more
Abstract:The nation is currently faced with the significant challenge of developing alternative sources of energy to meet our growing energy needs in a sustainable and environmentally responsible manner, while reducing carbon emissions. For a significant population of the western United States and the world… more
Conventional approaches to ocean energy are unlikely to make a material impact on global energy supply. HiFunda LLC and its affiliate Oscilla Power, Inc. are developing a utility-scale wave energy harvester enabled by low cost, domestically-and readily-available… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop new and improved materials for a novel wave energy device. We have developed a patent-pending concept for a no-moving-parts wave energy harvester that uses low-cost magnetostrictive alloys. This technology shows promise as… more
Abstract:In this SBIR project MagiCom proposes several innovative concepts to provide high speed, in-flight communication links between the Ballistic Missile Defense System (BMDS) Fire Control and Interceptor/Kill Vehicles such as the Ground Missile Defense - Exoatmospheric Kill Vehicle (GMD-EKV) and other… more
Abstract:DESCRIPTION (provided by applicant): This project addresses the process development and evaluation of an extremely flexible, Parylene C, micro-ribbon cable that is both biocompatible and biostable. Such a cable would be employed to link micro-electrode arr
ays with percutaneous connectors as well as… more
Abstract:DESCRIPTION (provided by applicant): Natural products are still the majority of therapeutic agents. However, they suffer from a difficulty in the creation of derivatives, and they can also be hard to supply. Derivatives are extremely important in the optim
ization of properties, such as toxicity or… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop an innovative process to significantly enhance the manufacturability of functionally graded cemented tungsten carbide (FGM WC-Co) by utilizing a high temperature carburization process. This technology is based on the… more
Abstract:Toxic compounds are a major health hazard in our environment, in our food, and in our pharmaceuticals. Identifying toxic compounds is currently time-consuming, expensive and complicated by animal rights issues. We propose to generate a set of 96 transgenic nematodes that will contain… more
Abstract:Shallow lagoon systems are the most common form of engineered domestic wastewater treatment in the United States and the world. Municipalities, particularly smaller rural communities, use this low cost treatment method. These lagoon systems are generally effective at reducing biochemical oxygen… more
Abstract:Rural farming communities, rural homeowners, the farmers, the small business/industries, the schools, and the municipalities need quality alternative energy solution to help offset all or a portion of their electrical power usage. In many instances the high cost of energy prohibits economic recovery… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will determine the scientific, technical, and commercial merit, and feasibility of building an innovative set of tools and web-based services called Open Educational Resources Glue (OER Glue). The National Science Foundation, Hewlett… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project involves testing and validation of a novel drug discovery platform. An original algorithm is used to design previously unknown peptides that are capable of modulating selected macromolecules of therapeutic importance. Then, such designer… more
Abstract:Despite its clean and green nature when utilized in fuel cells and other devices, most hydrogen is currently produced primarily from non-renewable sources, such as natural gas, oil, and coal. Anaerobic digestion provides a potentially improved alternative to manufacturing hydrogen from petroleum and… more
Abstract:This Small Business Innovation Research Phase I project will generate novel parental lines of hybrid industrial corn. These F1 hybrids, grown by U.S. farmers, will produce F2 seeds with much higher levels of starch and no embryos. This innovation will allow for an easier and more cost effective… more
Abstract:This project develops an electronic-controlled version of the advanced hydraulic foot/ankle (MCI Foot) demonstrating the feasibility of the automatic adjustment of resistance throughout the range of motion. The advanced MCI Foot, especially the automatic-controlled version, contributes to the… more
Abstract:Under the Phase I program, ASI will examine the available technologies for improving manipulation, create preliminary designs of how to integrate these technologies on current platforms (the Talon and Packbot), and simulate the effects of improved dynamic modeling and sensor feedback on manipulator… more
Abstract:Current mobile manipulators require extensive operator involvement to perform even simple tasks, such as opening a door, picking up an object, or emptying a container. f?oFly-the-gripperf?? algorithms have been implemented to free the user from specifying joint velocities when a desired x, y, z… more
Abstract:This SBIR Phase I proposal from Technology Holding LLC seeks to develop an advanced energy storage system to integrate with renewable energy systems. The high energy density can be achieved by using lithium anode and thermally stable cathode materials. Solid electrolytes are expected to be far less… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project aims to develop a manufacturing process to synthesize metal oxide, sulfide and other nanoparticles. The subject method simply involves mixing of common dry chemical starting materials and heating the resulting precursor material to a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to synthesize ATXRed, an in vivo imaging agent that is specifically activated by the enzymatic activity of autotaxin. Autotaxin is an extracellular enzyme that generates the phospholipid growth factor lysophophatidic acid (LPA). LPA… more
Abstract:DESCRIPTION (provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS). Application of this knowledge would accelerate the pace of basic and clinical research as well as benefit tens of thousand
s of U.S. patients each year. Primary… more
Abstract:DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this research is to develop a cell therapy for the treatment of neurological disorders that are due to dysfunctional astrocytes. Current approaches to cure or manage these diseases by small mo
lecule drugs are limited due to the… more
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