Abstract:This Small Business Innovation Research (SBIR) Phase I project involves testing and validation of a novel drug discovery platform. An original algorithm is used to design previously unknown peptides that are capable of modulating selected macromolecules of therapeutic importance. Then, such designer… more
Abstract:Despite its clean and green nature when utilized in fuel cells and other devices, most hydrogen is currently produced primarily from non-renewable sources, such as natural gas, oil, and coal. Anaerobic digestion provides a potentially improved alternative to manufacturing hydrogen from petroleum and… more
Abstract:This Small Business Innovation Research Phase I project will generate novel parental lines of hybrid industrial corn. These F1 hybrids, grown by U.S. farmers, will produce F2 seeds with much higher levels of starch and no embryos. This innovation will allow for an easier and more cost effective… more
Abstract:This project develops an electronic-controlled version of the advanced hydraulic foot/ankle (MCI Foot) demonstrating the feasibility of the automatic adjustment of resistance throughout the range of motion. The advanced MCI Foot, especially the automatic-controlled version, contributes to the… more
Abstract:Under the Phase I program, ASI will examine the available technologies for improving manipulation, create preliminary designs of how to integrate these technologies on current platforms (the Talon and Packbot), and simulate the effects of improved dynamic modeling and sensor feedback on manipulator… more
Abstract:Current mobile manipulators require extensive operator involvement to perform even simple tasks, such as opening a door, picking up an object, or emptying a container. f?oFly-the-gripperf?? algorithms have been implemented to free the user from specifying joint velocities when a desired x, y, z… more
Abstract:This SBIR Phase I proposal from Technology Holding LLC seeks to develop an advanced energy storage system to integrate with renewable energy systems. The high energy density can be achieved by using lithium anode and thermally stable cathode materials. Solid electrolytes are expected to be far less… more
Abstract:This Small Business Technology Transfer (STTR) Phase II project aims to develop a manufacturing process to synthesize metal oxide, sulfide and other nanoparticles. The subject method simply involves mixing of common dry chemical starting materials and heating the resulting precursor material to a… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to synthesize ATXRed, an in vivo imaging agent that is specifically activated by the enzymatic activity of autotaxin. Autotaxin is an extracellular enzyme that generates the phospholipid growth factor lysophophatidic acid (LPA). LPA… more
Abstract:DESCRIPTION (provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS). Application of this knowledge would accelerate the pace of basic and clinical research as well as benefit tens of thousand
s of U.S. patients each year. Primary… more
Abstract:DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this research is to develop a cell therapy for the treatment of neurological disorders that are due to dysfunctional astrocytes. Current approaches to cure or manage these diseases by small mo
lecule drugs are limited due to the… more
Abstract:The Air Force has identified a need for an advanced traveling wave tube amplifier (TWTA) that supports future generations of broad bandwidth, efficient and linear military satellite communication. To address this need, InnoSys proposes to develop innovative solutions for advanced TWTAs that operate… more
Abstract:InnoSys and Purdue University will continue to research and develop robust Phase I approaches for building, implementing and demonstrating a new class of terahertz (THz) vacuum electronic device (VED) power amplifiers and power sources at frequencies in the range of 0.3-3.0 THz (the THz regime)… more
Abstract:DESCRIPTION (provided by applicant): An unmet need for expansion of primary cells and progenitor cells in three dimensions (3-D) is an extracellular matrix (ECM) substitute with user-controllable composition and compliance to which ECM proteins or syntheti
c peptides can be covalently attached by… more
Abstract:A major problem faced by our warfighters utilizing a Micro Air Vehicle is its limited capability to provide wide area situational awareness and sense combatants under low visibility conditions such as night, rain, fog, dust, snow and sand. The other issue is that once a combatant is identified the… more
Abstract:This small business innovation research is intended to develop and proof the concept of a highly efficient, high temperature rechargeable battery for supporting Venus exploration missions. The proposed battery will be built upon a tubular, alkali metal ion-conducting, highly refractor,… more
Abstract:This Small Business Technology Transfer Research (STTR) Phase II proposal from Materials and Systems Research, Inc. (MSRI) and University of Utah (research institution) seeks to fabricate single-phase, polycrystalline tungstate ceramics with densities greater than 99.95% and a mean grain size of… more
Abstract:Efficient production of hydrogen from abundant fossil fuel reserves along with effective CO2 sequestration processes can lead to reduction of greenhouse gas emissions and elimination of dependence on foreign oil. Currently, hydrogen production via water-gas shift (WGS) reaction of either a… more
Abstract:DESCRIPTION (provided by applicant): Insufficient oxygenation of the blood (hypoxemia) is a common symptom in ICU patients, and may be caused by a combination of four different pathologies: 1) decreased alveolar ventilation (hypoventilation), 2) oxygen dif
fusion limitation, 3) inequality in… more
Abstract:DESCRIPTION (provided by applicant): In our Phase 1 application, we described an endothelial specific receptor, Robo4, that is expressed in mature vessels and is upregulated following endothelial injury. Robo4, following activation by its protein ligand, S
lit2, reduces agonist induced vascular leak… more
Abstract:DESCRIPTION (provided by applicant): Influenza infection leads to a cytokine storm as the host's immune system fights the virus. This combination of immunity factors has the unfortunate side effect of creating vascular leak. In the case of influenza patien
ts, this vascular leak most often occurs in… more
Abstract:The objective of this project is to develop a strategy to recover micro air vehicles into a flying aircraft. Our solution combines three key technologies that have received significant research attention in recent years, namely towed cable systems, cooperative control, and vision-based terminal… more
Abstract:The primary objective of the proposed effort is to develop a validated computational tool to predict the afterburning of non-ideal munitions containing metal and hydrocarbon fuels. The activities outlined devise a well-coordinated collaboration among researchers from Reaction Engineering… more
Abstract:Investigations into JP-10 combustion chemistry thus far can be characterized as preliminary. The detailed chemical kinetic mechanisms that have been published are limited in their ability to reproduce experimental data. The combustion chemistry of JP-10 is highly complex, involving hundreds if not… more
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