Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to synthesize ATXRed, an in vivo imaging agent that is specifically activated by the enzymatic activity of autotaxin. Autotaxin is an extracellular enzyme that generates the phospholipid growth factor lysophophatidic acid (LPA). LPA… more
Abstract:DESCRIPTION (provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS). Application of this knowledge would accelerate the pace of basic and clinical research as well as benefit tens of thousand
s of U.S. patients each year. Primary… more
Abstract:DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is… more
Abstract:DESCRIPTION (provided by applicant): The long-term objective of this research is to develop a cell therapy for the treatment of neurological disorders that are due to dysfunctional astrocytes. Current approaches to cure or manage these diseases by small mo
lecule drugs are limited due to the… more
Abstract:The Air Force has identified a need for an advanced traveling wave tube amplifier (TWTA) that supports future generations of broad bandwidth, efficient and linear military satellite communication. To address this need, InnoSys proposes to develop innovative solutions for advanced TWTAs that operate… more
Abstract:InnoSys and Purdue University will continue to research and develop robust Phase I approaches for building, implementing and demonstrating a new class of terahertz (THz) vacuum electronic device (VED) power amplifiers and power sources at frequencies in the range of 0.3-3.0 THz (the THz regime)… more
Abstract:DESCRIPTION (provided by applicant): An unmet need for expansion of primary cells and progenitor cells in three dimensions (3-D) is an extracellular matrix (ECM) substitute with user-controllable composition and compliance to which ECM proteins or syntheti
c peptides can be covalently attached by… more
Abstract:A major problem faced by our warfighters utilizing a Micro Air Vehicle is its limited capability to provide wide area situational awareness and sense combatants under low visibility conditions such as night, rain, fog, dust, snow and sand. The other issue is that once a combatant is identified the… more
Abstract:This small business innovation research is intended to develop and proof the concept of a highly efficient, high temperature rechargeable battery for supporting Venus exploration missions. The proposed battery will be built upon a tubular, alkali metal ion-conducting, highly refractor,… more
Abstract:This Small Business Technology Transfer Research (STTR) Phase II proposal from Materials and Systems Research, Inc. (MSRI) and University of Utah (research institution) seeks to fabricate single-phase, polycrystalline tungstate ceramics with densities greater than 99.95% and a mean grain size of… more
Abstract:Efficient production of hydrogen from abundant fossil fuel reserves along with effective CO2 sequestration processes can lead to reduction of greenhouse gas emissions and elimination of dependence on foreign oil. Currently, hydrogen production via water-gas shift (WGS) reaction of either a… more
Abstract:DESCRIPTION (provided by applicant): Insufficient oxygenation of the blood (hypoxemia) is a common symptom in ICU patients, and may be caused by a combination of four different pathologies: 1) decreased alveolar ventilation (hypoventilation), 2) oxygen dif
fusion limitation, 3) inequality in… more
Abstract:DESCRIPTION (provided by applicant): In our Phase 1 application, we described an endothelial specific receptor, Robo4, that is expressed in mature vessels and is upregulated following endothelial injury. Robo4, following activation by its protein ligand, S
lit2, reduces agonist induced vascular leak… more
Abstract:DESCRIPTION (provided by applicant): Influenza infection leads to a cytokine storm as the host's immune system fights the virus. This combination of immunity factors has the unfortunate side effect of creating vascular leak. In the case of influenza patien
ts, this vascular leak most often occurs in… more
Abstract:The objective of this project is to develop a strategy to recover micro air vehicles into a flying aircraft. Our solution combines three key technologies that have received significant research attention in recent years, namely towed cable systems, cooperative control, and vision-based terminal… more
Abstract:The primary objective of the proposed effort is to develop a validated computational tool to predict the afterburning of non-ideal munitions containing metal and hydrocarbon fuels. The activities outlined devise a well-coordinated collaboration among researchers from Reaction Engineering… more
Abstract:Investigations into JP-10 combustion chemistry thus far can be characterized as preliminary. The detailed chemical kinetic mechanisms that have been published are limited in their ability to reproduce experimental data. The combustion chemistry of JP-10 is highly complex, involving hundreds if not… more
Abstract:The proposed project will leverage REI's experience creating and applying reduced chemical kinetic mechanisms for JP-8 with source-term speed-up techniques such as in-situ adaptive tabulation (ISAT) and artificial neural networks (ANN) to develop techniques for speeding evaluation of JP-8 kinetics… more
Abstract:With the current state of world events, the threat of buried explosives used against military vehicles is more pronounced than ever before. The introduction of the MRAP and MTVR vehicles have helped mitigate this threat to a degree, but military personnel continue to suffer from both death and… more
Abstract:Natural gas, which is predominantly methane, is widely used by industry as a chemical feedstock and as a fuel for power generation. The increasing price and diminishing domestic supply of natural gas creates an incentive to develop a low-cost replacement for the fuel. Coal gasification is one… more
Abstract:OBJECTIVE: Develop a fast running Computational Fluid Dynamics (CFD) Finite Element code taking advantage of hardware and software technologies developed in the gaming industry. The CFD code will be used to model highly non-linear and dynamic external blast events in urban settings and internal… more
Abstract:Coal gasification plants have exhibited sub-par performance and plant economics due to poor reliability and availability. A major contributor to the poor performance has been fouling of the syngas cooler located downstream of the gasifier. The fouling is due to vaporized ash from the coal… more
Abstract:Composite materials utilizing graphite fibers can exhibit high axial thermal conductivities. However, thermal conduction perpendicular to the fiber direction in the composite is extremely low due to the acoustical mismatch between the carbon fiber and epoxy. Sommer Materials Research, Inc.… more
Abstract:A need for miniaturized mass spectrometer (MS) instrumentation exists for both stationary point monitoring and applications where instrument size is critical, including military swatch test monitoring of chemical agent permeation rates and field detection of chemical agents. A 50% size and weight… more
Abstract:The objective of this work is to provide guidance to explosive formulators and facilitate the development of improved penetrator explosives. Because of the complexity of these materials, it is difficult to relate parameters controllable during formulation to desirable properties in the final product… more
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