Abstract:DESCRIPTION (provided by applicant): This Phase I proposal details the rationale and the research plan for the synthesis and characterization of a polymeric delivery system that will deliver two anticancer drugs with diverse mechanisms of action simultaneously into ovarian cancer cells. The delivery… more
Abstract:DESCRIPTION (provided by applicant): In this Phase II STTR project, Vestan Medical Imaging, Inc. will complete the development and clinical evaluation of its proprietary formulation of a fluorescent drug and new medical devices for Sentinel Lymph Node (SLN) biopsy for the surgical treatment of… more
Abstract:To improve safety and efficiency on high-speed signalized intersections a dilemma zone protection system has been designed to automatically configure site-specific protection boundaries on both main-street approaches by continously tracking vehicles within up to 1000 feet of each stop line. … more
Abstract:Wavetronix currently sells the SmartSensor HD radar detection which is the highest performance above ground detector currently available. However, the count, speed and classification accuracy can be significantlly improved by employing multi-beam radar technology which we have recently… more
Abstract:This Small Business Innovation Research Phase I research project involves the development of inexpensive, reconfigurable force-reflective telerobotic manipulators. Incorporating dexterous manipulators onto available mobile robotic platforms greatly expands the capabilities and usefulness of the… more
Abstract:During Phase I, goals of initial design and demonstration of system concepts for a portable friction stir welding (FSW) system were successfully completed. During Phase II, the objective is to design, fabricate, and demonstrate a portable and versatile FSW system. To support AMP's design, BYU will… more
Abstract:A battery is proposed that utilizes a Li+ conducting, solid-electrolyte separator, LiSICON, Li metal anode and high-capacity cathode. The LiSICON ceramic is fabricated using state of the art tape casting methods which allows composite structures of porous and dense layers ~100fYm thick. The layered… more
Abstract:The proposed research will develop a probabilistic decision analysis methodology and software framework applicable to Chemical, Biological, Radiological and Nuclear (CBRN) threats and incidents. The software prototype developed in the Phase I research will include tools to enable probabilistic… more
Abstract:U.S. and world petroleum supplies are limited, causing substantial increases and fluctuations in the cost of liquid fuels and national energy insecurity. If the vast western oil shale reserves could be economically and cleanly recovered, the country¿s transportation fuel problems would be… more
Abstract:Compositex, Inc. proposes to continue the development of a promising new material and fabrication technology for high performance motor cases and propellant tanks. This process using readily-available, low-cost, domestically-produced, environmentally-friendly thermoplastic raw materials. High-cost… more
Abstract:This Small Business Innovation Research Phase I project addresses the development of a novel solid-state method of synthesizing metal and metal alloy nanoparticles. A method has been developed for metal oxide and mixed metal oxide nanoparticles which can now be extended to the synthesis of metal and… more
Abstract:DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the ra
pid detection of glycosylation patterns is… more
Abstract:DESCRIPTION (provided by applicant): Immunocompromised patients including those who have undergone hematopoietic stem cell (HSCT) and solid organ (SOT) transplants are at markedly increased risk for severe disease caused by respiratory pathogens. These pat
ients have greater susceptibility to a… more
Abstract:InnoSys and Purdue University propose to research and develop robust designs for building, implementing and demonstrating a new class of terahertz (THz) vacuum electronic device (VED) power amplifiers and power sources at frequencies in the range of 0.3-3.0 THz (the so-called THz regime)… more
Abstract:Efficient shipboard naval lighting is important for numerous reasons. There is also a need for efficient explosion-proof lighting coupled with reliable dimmable driver electronics for shipboard naval environments. Important considerations for such an efficient and dimmable light include ensuring… more
Abstract:DESCRIPTION (provided by applicant): Long-term continuous recording of electrical events from animal models of neurological disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epi
lepsy. Recordings of the… more
Abstract:DESCRIPTION (provided by applicant): Rosacea is a common disfiguring skin disease affecting 3% of the population over 30 years of age, or 14 million Americans. In men and women of Celtic origin, Rosacea causes central erythema of the face, with highly vis
ible dilated blood vessels and pustules.… more
Abstract:DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a leading cause of blindness in the U.S., affecting 8 million Americans over fifty years of age. Its cause is rooted in the highly oxidizing environment of the retina, which is
simultaneously exposed to UV light and high… more
Abstract:DESCRIPTION (provided by applicant): The realization of the remarkable potential of human embryonic stem cells or induced pluripotent stem cells to treat human disease cannot occur unless new animal-free methods for the expansion of undifferentiated stem c
ells are developed. An optimal… more
Abstract:A major problem faced by our warfighters utilizing a Micro Air Vehicle is its limited capability to sense combatants under non-optimal environmental conditions. The other issue is that once a combatant is identified the warfighter must personally engage the combatant exposing the warfighter to… more
Abstract:DESCRIPTION (provided by applicant): Currently there are 40 million people estimated to be infected with HIV/AIDS worldwide; 22 million people have died since its discovery in 1980's. Drugs inhibiting the reverse transcriptase (RT), protease, and integrase
- three essential enzymes for the… more
Abstract:Analytic Design Laboratories proposes a Next Generation FPGA that is deterministically place and routable. Conventional FPGAs rely on synthetic annealing to optimize function placement and connection routing. Synthetic annealing randomly moves functions and connecting paths to improve circuit… more
Abstract:Analysis of Phase I test data demonstrates that the Photogenics Spectroscopic Dosimeter will detect neutron energies from 0.8 up to 600 MeV. The detector efficiencies in the energy region of interest to NASA of 0.5 to 150 MeV were predicted by MCNP-X models. These models were partially confirmed by… more
Abstract:DESCRIPTION (provided by applicant): Responding to ever increasing need for blood substitutes, scientists have developed two types of artificial oxygen carriers (AOC), polymeric hemoglobin and perfluorocarbon based AOC. While they are capable of supplying
oxygen to the tissue, their side effects… more
Abstract:DESCRIPTION (provided by applicant): The goal of this program is to create an implantable stimulator device to restore functional eye blink in patients with unilateral facial nerve paralysis. The system will electrically stimulate the paretic eyelid when E
MG electrodes detect normal blink from the… more
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