Abstract:DESCRIPTION (provided by applicant): Rosacea is a common disfiguring skin disease affecting 3% of the population over 30 years of age, or 14 million Americans. In men and women of Celtic origin, Rosacea causes central erythema of the face, with highly vis
ible dilated blood vessels and pustules.… more
Abstract:DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a leading cause of blindness in the U.S., affecting 8 million Americans over fifty years of age. Its cause is rooted in the highly oxidizing environment of the retina, which is
simultaneously exposed to UV light and high… more
Abstract:DESCRIPTION (provided by applicant): The realization of the remarkable potential of human embryonic stem cells or induced pluripotent stem cells to treat human disease cannot occur unless new animal-free methods for the expansion of undifferentiated stem c
ells are developed. An optimal… more
Abstract:A major problem faced by our warfighters utilizing a Micro Air Vehicle is its limited capability to sense combatants under non-optimal environmental conditions. The other issue is that once a combatant is identified the warfighter must personally engage the combatant exposing the warfighter to… more
Abstract:DESCRIPTION (provided by applicant): Currently there are 40 million people estimated to be infected with HIV/AIDS worldwide; 22 million people have died since its discovery in 1980's. Drugs inhibiting the reverse transcriptase (RT), protease, and integrase
- three essential enzymes for the… more
Abstract:Analytic Design Laboratories proposes a Next Generation FPGA that is deterministically place and routable. Conventional FPGAs rely on synthetic annealing to optimize function placement and connection routing. Synthetic annealing randomly moves functions and connecting paths to improve circuit… more
Abstract:Analysis of Phase I test data demonstrates that the Photogenics Spectroscopic Dosimeter will detect neutron energies from 0.8 up to 600 MeV. The detector efficiencies in the energy region of interest to NASA of 0.5 to 150 MeV were predicted by MCNP-X models. These models were partially confirmed by… more
Abstract:DESCRIPTION (provided by applicant): Responding to ever increasing need for blood substitutes, scientists have developed two types of artificial oxygen carriers (AOC), polymeric hemoglobin and perfluorocarbon based AOC. While they are capable of supplying
oxygen to the tissue, their side effects… more
Abstract:DESCRIPTION (provided by applicant): The goal of this program is to create an implantable stimulator device to restore functional eye blink in patients with unilateral facial nerve paralysis. The system will electrically stimulate the paretic eyelid when E
MG electrodes detect normal blink from the… more
Abstract:The objective of this proposal is to develop a feasible design for intermittent electrical fault detection and location for a weapons system using analog S/SSTDR for continual monitoring. We have already demonstrated the feasibility of the basic S/SSTDR technology for live aircraft in flight where… more
Abstract:In the transition from current gasoline-based vehicles, hydrogen home fueling systems will play an important role in the market adoption of hydrogen-based vehicles. This project will investigate the development of such a system for the tri-generation of hydrogen, electricity, and heat. The… more
Abstract:This small business innovation research is intended to develop a simple processing concept based-on an advanced direct carbon fuel cell (DCFC) technology enabling directly converting plastic trash into life support consumables (such as H2, CO2 and H2O) and electricity simultaneously, for supporting… more
Abstract:Temperature sensors that can monitor temperature directly on various locations in gas turbine engines are necessary for prognosis and diagnosis of engine conditions during operation. However, reliable temperature sensors working under the harsh conditions of jet propulsion are not currently… more
Abstract:Hydrogen has been widely used by petroleum refineries in upgrading processes necessary to facilitate the hydrotreating/catalytic hydrocracking of heavy hydrocarbon molecules and the reduction of sulfur content. However, the building of the infrastructure needed to transport hydrogen from central… more
Abstract:In planar Solid Oxide Fuel Cells (SOFC), separation of the anode and cathode side gases are achieved by hermetic seals. These seals may be rigid, compressive, or compliant. However, the design of improved sealing materials must address two major challenges: (1) mechanical stability of the seals… more
Abstract:Solid oxide fuel cells (SOFCs) will play a key role in a highly efficient, near-zero-emission coal-based power generation system. To achieve the target system efficiency, SOFC anodes must be able to tolerate or mitigate the effect of certain coal contaminant compounds such as hydrogen sulfide,… more
Abstract:A viable approach is needed to economically and efficiently produce pure hydrogen. This project will develop a ¿4-in-1¿ device to thermally consolidate the water-gas-shift reaction by combining hydrogen separation, purification, and compression processes. This device will be built upon a… more
Abstract:DESCRIPTION (provided by applicant): Diagnostic Monitor to Guide Early Goal-Directed Therapy in Emergency Departments Summary Mortality rates for critically ill patients are unnecessarily high because of the extended time (6-7 hrs) that it usually takes fo
r diagnoses to be rendered in Emergency… more
Abstract:Motion Control will develop an innovative body-powered (BP) upper extremity (UE) prosthetic system which offers substantial improvements in functionality, comfort, and aesthetics, for persons with UE deficiencies at all levels. This “Utility Arm” system will in¬crease independence… more
Abstract:This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Innovation Research (SBIR) Phase II project will combine lighter weight and quiet piezoelectric technology into an innovative Multi-Grip Prosthetic Hand. Current prosthetic hands… more
Abstract:Motion Control, Inc. (MCI) will complete an electronic-controlled version of the advanced hydraulic foot/ankle which will demonstrate the feasibility of the automatic adjustment of resistance throughout the range of motion. The advanced MCI Foot, especially the automatic controlled version,… more
Abstract:DESCRIPTION (provided by applicant): In our Phase I application, we proposed that blocking HTRA1 with antibodies might be an effective strategy for treating age related macular degeneration. We tested this hypothesis by a) generating monoclonal antibodies
against HTRA1 and b) determining whether a… more
Abstract:DESCRIPTION (provided by applicant): Many human diseases-if not all human diseases-and human health appear to be linked to our genetics. Major government and private research efforts are focused on investigating this linkage. Unfortunately, one of our bes
t tools for this critical work-i.e.,… more
Abstract:ddddThe objective of this project is to develop a strategy to recover micro air vehicles into a flying aircraft. Our solution combines three key technologies that have received significant research attention in recent years, namely towed cable systems, cooperative control, and vision-based terminal… more
Abstract:Procerus Technologies, along with its partner Brigham Young University, propose to develop cooperative control technologies to enable multiple small, unmanned air vehicles (SUAVs) to carry out a mission involving search, tracking, imaging, and localization (STIL). The goal is to carry out these… more
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