Abstract:DESCRIPTION (provided by applicant): Genome engineering is an emerging field in which genomic DNA sequences are modified for biotechnological and therapeutic purposes. Highly specific endonucleases are the key tool that enables genome engineering approaches, as they are required to create… more
Abstract:DESCRIPTION (provided by applicant): The use of virtual reality for pain control; henceforth, referred to as VR analgesia, has been shown to be effective in clinical treatment of acute pain in wound care, cancer care, physical therapy and routine hospitalprocedures. VR is believed to be effective… more
Abstract:Conversion of lignocellulosic biomass to liquid transportation fuels and bioproducts is a core element of our nations strategy to replace imported oil with renewable domestic resources. Thermo chemical conversion processes typically require feedstocks 5 to 7.5 times drier than the raw materials and… more
Abstract:The PowerCube is a 1U CubeSat module that provides integrated propulsion, power, and precision pointing to enable the low-cost CubeSat platform to be used to conduct high-performance missions. The PowerCube concept integrates three innovative component technologies to provide these capabilities: … more
Abstract:ABSTRACT: The goal of the Space Test Program operated by the US Air Force is to enable the rapid development of emerging space technologies by providing economical flight opportunities to increase a technology"s TRL. In particular, the CubeSat form factor has emerged as an economical platform… more
Abstract:ABSTRACT: We propose to adapt additive manufacturing techniques to fabricate multifunctional"Versatile Structural Radiation Shielding"(VSRS) components that provide multi-layer radiation shielding, multi-layer thermal insulation, electro-magnetic interference (EMI) shielding, and… more
Abstract:Tethers Unlimited, Inc. proposes to develop the Remote Anchoring Module (RAM), a launch-able anchoring system that can be used to quickly set and test an anchor point at a remote location without the need for an on-site operator. The RAM system deploys a high-strength cable between itself and the… more
Abstract:TUI proposes to develop two novel technologies that will enable pico-satellites in LEO to efficiently close the link with standard issue handheld radios on the ground. The first technology is a dual-band software-defined radio that will provide UHF SATCOM to soldiers on the ground and a unified… more
Abstract:DESCRIPTION (provided by applicant): Three novel uncharged silver carbene microbicides that have been shown to be effective against a wide variety of pathogens will be formulated into two different ointment formulations and tested in an infected healing model in the diabetic rat. Formulation of the… more
Abstract:DESCRIPTION (provided by applicant): Burkholderia pseudomallei is a Gram-negative bacterium that is the causative agent of melioidosis. The bacterium causes significant morbidity and mortality in tropical regions and endemic areas are expanding. Melioidosis is difficult to trea and diagnose due to… more
Abstract:DESCRIPTION (provided by applicant): The very common patient complaint of abdominal pain suggests the diagnosis of pancreatitis. Pancreatitis, however, can be difficult to diagnose or rule out, as the blood-based tests used, serum amylase and lipase, demonstrate suboptimal sensitivity and… more
Abstract:The cost of logistics fuels, including transportation and distribution, is significant not only in terms of dollars but also increased risk exposure for soldiers. Concentrated solar thermal (CST) systems are an attractive renewable energy solution due to their high net average efficiencies of… more
Abstract:Americas transportation sector relies almost exclusively (94%) on refined petroleum products, accounting for over 70% of the oil used. Nearly 9 million barrels of oil are required every day to fuel the 247million vehicles that constitute the U.S. lightduty transportation fleet. Biomass from… more
Abstract:DESCRIPTION (provided by applicant): This fast-track proposal applies advanced kinetic image pattern recognition (KIPR) technologies to predict induced pluripotent stem cell (iPSC) reprogramming colonies' differentiation outcomes for significantly improvedyield and robustness of differentiation… more
Abstract:DESCRIPTION (provided by applicant): Significance: End Stage Renal Disease (ESRD) affects a rapidly growing population likely to exceed 1 million patients in the US by 2020. The standard treatment of 3 times per week hemodialysis (HD) has high complicationrates and infection risks, results in… more
Abstract:DESCRIPTION (provided by applicant): The primary goal of this proposal is to develop opioid peptide aerosol-compatible formulations and an intranasal drug delivery system to deliver mu/delta opioid peptides to the central nervous system (CNS) in effectiveconcentrations as the first step in… more
Abstract:We envision a class of miniature robotic aircraft dubbed Flexrotors which offer range, endurance, and economy at levels associated with wing-borne flight, together with capability for hover and fully-automated turnaround. Routine operations of these aircraft will include dynamic transitions between… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research project addresses the problem of biomarker detection in clinical and high-throughput data. The objective is to investigate new approaches for deter- mining, from data consisting of many possibly irrelevant or redundant… more
Abstract:Multiform Harvest Inc. ("Multiform") produces the fertilizer struvite, which is magnesium ammonium phosphate hexahydrate. Multiform produces the struvite by extracting it from wastewaters containing excess phosphorus. Multiform sells into two markets: 1) wastewater generators who need to… more
Abstract:To realize laser-driven inertial fusion energy with economically viable efficiency and repetition rates, pumping the laser system with semiconductor diode lasers instead of the flashlamp will be essential. Diode laser prices are currently much too high for practical implementation of fusion energy.… more
Abstract:nLight proposes to suppress the key remaining output power extraction limiter COMD failure mechanism by passivating the cleaved facet of laser diodes with high bandgap semiconductor layers that is epitaxially grown in an atomically conformal manner at low temperature and in ultra-high vacuum.
Abstract:nLight proposes a novel semiconductor laser device operating at ~976 nm with a spatially single mode laser that is separately addressable to generate a few hundred milliwatts of power and then subsequently amplified to>10 watts with a separate electrical contact in a larger gain area while… more
Abstract:Higher power wavelength-stabilized pump sources operating in the 78x-nm to 79xnm band are expected to enable high-energy CW laser systems based on low pressure alkali gasses (such as Cs or Rb). Under the proposed program, nLight will design, demonstrate, and deliver to the MDA (or recipient of their… more
Abstract:Improving efficiency as well as increasing operating temperature of laser diode pumps for high-power fiber lasers has a far-reaching implication in terms of significantly improving the overall stringent size, weight and power (SWAP) requirements, thus enabling DEW-class fiber lasers on airborne… more
Abstract:nLight proposes to develop and commercialize an innovative kilo-watt class fiber laser pump combiner which is especially suited for counter-pumping architectures that is indispensable for various coherent combining techniques. The key advantages of this proposed technology over the current… more
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