Abstract:Aging aircraft experience fatigue cracking from stress concentrations around rivet holes. Current best practice is to pull an oversized mandrel through a split sleeve in the hole to induce beneficial residual compressive stresses and this improves fatigue life significantly. However, the benefit is… more
Abstract:Orora Design Technologies, Inc. proposes to develop an innovative computer-aided design (CAD) based methodology and enabling tools for rapid radiation-hardened prototyping and migration of military satellite microelectronics. A key innovative tool to be explored is automated generation and… more
Abstract:The goal of this research is to develop electronic design automation (EDA) tools to automate the following three major radiation-hardened-by-design (RHBD) tasks: (1) The capture of RHBD design constraints and design rules for sub-90nm mixed-signal designs in an industry-standard EDA data base, … more
Abstract:DESCRIPTION (provided by applicant): Lyso, a metalloendopeptidase that is bacteriolytic for S. aureus, is a potential systemic therapy for treating methicillin-resistant S. aureus (MRSA) mediated infections including endocarditis, osteomyelitis, catheter related infections, and MRSA-mediated… more
Abstract:DESCRIPTION (provided by applicant): Psoriasis is a chronic inflammatory skin disease that to this date is only insufficiently controlled by currently available treatments which can also come with severe, and sometimes life threatening side effects. In this application, we propose to create a new… more
Abstract:Many fungal and bacterial pathogens produce proteolytic enzymes that facilitate penetration into fish skin or eggshells. These diseases are a major and growing challenge to sustainable aquaculture in the United States. Our Phase I research results demonstrated the feasibility of new, non-toxic,… more
Abstract:This SBIR program will develop a lightweight, high performance ceramic matrix composite thruster for DACS propulsion. The Phase I program will identify the sealing and joining materials, and demonstrate the processes that are suited for construction of advanced ceramic matrix composite (CMC)… more
Abstract:Laser wakefield acceleration (LWFA) has demonstrated the ability to accelerate electrons in a plasma with gradients & gt;30 GeV/m where a capillary discharge is used as the plasma source. The capillary discharge has a parabolic plasma density profile that is able to guide the focused laser beam… more
Abstract:DESCRIPTION (provided by applicant): Tramadol is a widely prescribed analgesic, with over 25 million prescriptions and 565 million in retail sales in 2009, making it among the best selling generic drugs. One of the advantages of tramadol over traditionalopioids is its lower risk of opioid… more
Abstract:Systima is developing a high performance 25 lbf DACS thruster that operates with a novel non-toxic monopropellant. The monopropellant has a 30% higher density-specific impulse compared to hydrazine and is commercially available off-the-shelf. In Phase I Systima will focus on development of the… more
Abstract:Systima is developing an IM compliant High Performance Green Propellant (HPGP) DACS thruster that operates with a novel non-toxic monopropellant. The monopropellant has a 30% higher density-specific impulse compared to hydrazine, insensitive/ not a detonation hazard, and is commercially available… more
Abstract:Systima Technologies, Inc. (Systima) is proposing to develop an end-to-end integrated All-Up-Round (AUR) canister solution to provide a multiple missile launcher (MML) for Extended Area Protection & Survivability (EAPS) missiles. By allowing a single MML-AUR to provide multiple EAPS missiles the… more
Abstract:DESCRIPTION (provided by applicant): Primary Care Providers (PCPs) have the opportunity to identify and intervene with alcohol abusers and risky users at an early stage, preventing many negative health and societal consequences. Screening and brief intervention (SBI) for substance use problems is an… more
Abstract:DESCRIPTION (provided by applicant): Approximately one-third of those who turned 65 in 2010 will enter a nursing home for short or long-term stay in their lifetime. Although the older adult population is growing more diverse, the current population of nursing home residents is 86% White and 62%… more
Abstract:DESCRIPTION (provided by applicant): Modifiable behavioral risk factors for diabetes and cardiovascular disease, two of the most costly diseases in both human and monetary terms, include obesity, lack of physical activity, smoking tobacco and excess alcohol consumption. Despite a longstanding… more
Abstract:A majority of rainbow trout produced in the US are derived from all-female stocks due to improved harvest traits and efficiency over mixed sex stocks. The development of all-female stocks currently relies on the use of the testosterone derivative 17 & #945; & #8722;methyltestosterone,… more
Abstract:This proposal addresses the problem of long term mapping and monitoring of subsurface geochemical and microbial activity associated with the transport and remediation of subsurface contaminants, including radionuclides and metals. The ability to map and monitor bioremediation processes in the near… more
Abstract:Vista Clara proposes to design, develop and demonstrate non-invasive NMR sensor capable of profiling moisture content in the top 2m of the subsurface. As a Phase 1 option, Vista Clara proposes to design, assemble and demonstrate a minimally-invasive NMR sensor for profiling moisture content in the… more
Abstract:DESCRIPTION (provided by applicant): Gene-expression reporter assays bridge bioinformatics data with gene-specific bioassays to monitor effects of ligands, compounds, antibodies, siRNAs, miRNAs, and peptides on gene expression. In cell culture, they provide for bench top or high throughput screening… more
Abstract:DESCRIPTION (provided by applicant): Project Summary/Abstract Current radioembolic Y-90 microspheres have been generally recognized as the state-of-the-art for treating primary and metastatic liver tumors. However, the clinical results vary vastly dueto the lack of accurate diagnostic imaging… more
Abstract:ABSTRACT: State of the art Orbital Transfer Vehicle systems require the demanding combined requirements of both high Thrust-to-Power (greater than 120 mN/kW) and high specific impulse (greater than 3000 s), all at constant power. The 25 kW PROTEAN system is a two-stage plasmoid thruster which adds… more
Abstract:ABSTRACT: MSNW"s Electrodeless Lorentz Force (ELF) thruster will address the demanding combined requirements of light weight, high efficiency, and high thrust-to-power electric propulsion in a single device. As spacecraft power systems get lighter, traditional electric propulsion thruster, PPU… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project will result in a commercially viable network of low cost wireless sensors that predict electric motor failure before failure occurs. American industries and manufacturers rely heavily on electric motors to power their equipment and… more
Abstract:Ocean wave energy has the potential to support 8% of domestic and global electricity demand. Despite considerable investment over the past decade, however, wave energy is unlikely to make a material contribution to domestic or global energy supplies unless new technologies with significantly lower… more
Abstract:DESCRIPTION (provided by applicant): At the frontier of biological electron microscopy, there is a strong emphasis on imaging the 3-D structure of cells, organelles, and macromolecules in their native state. This is facilitated by the use of frozen-hydrated specimens which have not been… more
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