Abstract:This Phase I project will demonstrate the feasibility of using specially modified contact lenses combined with an LCD display illuminated with a wave-guided backlight to enable an 80 degree field of view see-through display. The new eyewear architecture being proposed is a radical departure from… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the design of a robust and low-cost enzyme immobilization system to increase the cost-competitiveness of bio-catalytic processes. The lack of a universal, sound, and affordable enzyme immobilization technique has been a large… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project focuses on the development of a high-yield fermentation route for the production of levulinic acid (LA). LA is one of the best-suited C5 building blocks for bio-refinery production due to higher value, broad applications, and likely… more
Abstract:DESCRIPTION (provided by applicant): PSMA is an important biomarker for prostate cancer prognosis and an appropriate target for therapy due to its restricted expression mainly on late-stage, androgen-independent and metastatic prostate cancer cells. Whilecurrently there is only one clinical PSMA… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project aims to demonstrate the extraordinary performance of zwitterionic technology in protein interaction analysis. Zwitterionic polycarboxybetaine (pCB) is not only highly resistant to nonspecific protein adsorption, but also has abundant… more
Abstract:The overall objective of this SBIR is to provide the Sea Base, i.e., a flotilla of ships that may be holding station or slowly transiting an area, with a complete systems concept for a quick-to-establish, low-maintenance, durable system of temporary breakwater. Such a floating breakwater is to… more
Abstract:Researchers are currently hindered from observing dynamic gas-solid interactions in the transmission electron microscope (TEM). Yet, solid-state materials and gases interact in many important ways. The most critical technological application for these observations is catalysis, where one would like… more
Abstract:The primary experimental method used to determine the local internal structure of materials is that of transmission electron microscopy (TEM). If one also subjects the sample to an excursion in temperature during imaging at high resolution, one can watch the material processes involved in structural… more
Abstract:Wildlife Computers presents a remote release device for use with marine mammal data-logging tags proposed with three variations to suit cetaceans and large and small pinnipeds. The device uses innovative approaches such as ElectRelease epoxy for the releasing mechanism and an Argos-based signaling… more
Abstract:The motivation for this research project is to develop nanocomposite material for biomimetic bone repair material that meets all the requirements of solicitation N102-179. This project will provide the means to produce an advanced composite of materials with known efficacy to leverage the mechanical… more
Abstract:DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global… more
Abstract:The Lightweight High-Speed Amphibious Vehicle SBIR topic seeks to explore innovative concept designs and associated enabling technologies applicable to replacing the existing 5 ston Lighter, Amphibious Supply, Cargo"LARC V". However, there are a multitude of different organizations with… more
Abstract:DESCRIPTION (provided by applicant): The purpose of the proposal is to develop medical device coatings that bind and release therapeutic proteins, particularly growth factors. Specifically, we propose to systematically optimize and control growth factor binding and release using protocols that can… more
Abstract:DESCRIPTION (provided by applicant): Large mandibular segmental defects resulting from tumor resection, trauma, and congenital anomalies remain one of the most difficult clinical challenges in CMF reconstruction. Autologous tissue grafts and synthetic materials are the current clinical gold standard… more
Abstract:NASA needs advanced power-conversion technologies to improve the efficiency and reliability of power conversion for space exploration missions. We propose to develop a Stirling generator to meet NASA needs. Our Stirling generator adapts technology we have developed for high-reliability long-life… more
Abstract:The Air Force needs highly reliable, reusable, low-cost engine valves for reusable liquid rocket booster engines. We propose to develop a Frictionless Ball Valve (FBV) to meet Air Force needs. Our FBV uses friction-free hydrostatic bearings to maintain tight clearance seals and eliminate wear,… more
Abstract:DESCRIPTION (provided by applicant): Post-traumatic stress disorder (PTSD) is a common anxiety disorder with lifetime prevalence in the U.S. of 6.8%. Prolonged Exposure (PE), an exposure-based treatment developed by Edna Foa, Ph.D. and colleagues, is a highly efficacious treatment for PTSD. PE is… more
Abstract:Based on Cascade Designs expertise at developing individual water purification systems for the military and outdoor markets, we are proposing a novel in-line filter design that is based on incorporating multiple water purification technologies contained in a MOLLE compatible filter housing. Our… more
Abstract:Background: Surgical error reduction requires addressing rapid adoption of new surgical technology. We propose development of a networked surgical assessment platform able to collect performance and outcomes data from multiple surgical platforms and sites for dynamic metrics analysis. Goal:… more
Abstract:The ongoing military conflicts demonstrate the need to deploy skilled personnel equipped with advanced technology to provide medical and surgical attention as close as possible to the point of injury. A major problem is the occasional mismatch between the type of injury and the type of surgeon… more
Abstract:In modern fusion concepts, inductive pickup loops continue to be one of the primary magnetic diagnostics. This is due to their simple construction, ease of use, and durability, especially when compared to other methods of determining magnetic profiles. Inductive pickup loops are capable of extremely… more
Abstract:Innovative Confinement Concepts (ICC), like the spheromak and the field reversed configuration (FRC), provide an opportunity to study magnetic confinement in geometries other than the tokamak and may provide an alternative path to fusion energy. Many ICCs require a pre-ionizer or plasma injector in… more
Abstract:DESCRIPTION (provided by applicant): We will apply nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography to study enzymes from the methyl erythritol isoprenoid (MEP) biosynthetic pathway, which is essential in multiple pathogens and absent in humans. Identification and biophysical… more
Abstract:DESCRIPTION (provided by applicant): This Phase I project will evaluate the feasibility of developing an exposure monitor for particles in the PM2.5 and PM10 size ranges, and for volatile organic compounds (VOCs), at threshold levels for children's healtheffects. The proposed device will use… more
Abstract:DESCRIPTION (provided by applicant): The proposed project will develop and demonstrate a miniaturized, portable aerosol sampler that will collect a series of time- and location-resolved personal exposure samples for conducting research into the relationships among environmental exposure, genetics… more
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