Abstract:DESCRIPTION (provided by applicant): Primorigen Biosciences(R) Project Abstract Primorigen will use SBIR funds to develop a paradigm-changing technology for expansion and directed differentiation of human pluripotent stem cells (hPSCs) using a novel peptide that dramatically reduces costs by… more
Abstract:DESCRIPTION (provided by applicant): CRM197 is an inactive form of diphtheria toxin that, when conjugated to a vaccine antigen, enhances immunity to generate long-lasting vaccination against the antigen. Conjugate vaccines containing CRM197 are common andthere are currently seven CRM197-containing… more
Abstract:DESCRIPTION (provided by applicant): Monoclonal antibodies (mAbs) have become the leading drug class for cancer treatment, and over 150 anti-neoplastic mAbs are in the biopharmaceutical pipeline. Most mAb therapies must be administered in doses of 4-15 mg/kg, resulting in per patient costs of up to… more
Abstract:A major factor impacting development of Liion batteries for vehicles is the effect of elevated temperature ( & gt;50C) on battery life. Calendar and cycle life degrade at elevated temperatures due to degradation processes involving the interaction of the salt, solvents, and electrodes… more
Abstract:Many detectors - including solid-state particle detectors, microchannel plates, and photodiodes - output small current signals that require amplification and conversion to a voltage. Transimpedance amplifiers (TIA) are widely utilized in experimental and commercial applications for this task.… more
Abstract:DESCRIPTION (provided by applicant): Most drugs interact with protein molecules to elicit a cellular response. Traditional drug discovery is a laborious and expensive experimental process, so computational approaches to assess protein function and to accelerate the discovery process are in high… more
Abstract:DESCRIPTION (provided by applicant): Therapeutic monoclonal antibodies bind to specific regions of proteins called epitopes, which elicits cellular responses. Traditional antibody discovery processes require laborious and expensive screening experiments, so computational approaches that predict… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a graphene-gold nanoparticle-based sensing platform for detection of Escherichia Coli (E. Coli) bacteria in water. Real-time, inline detection of E. coli in water is an unmet need but critical for water quality monitoring… more
Abstract:The broader impact/commercial potential of this project is determined by new consumer products and new industries which would flourish on portable and reliable atomic clocks, gyroscopes, and magnetometers when they become available. Proposed compact thermal and magnetic enclosure reduces the most… more
Abstract:The broader impact/commercial potential of this project will be to remove a barrier to commercialization of low-cost vacuum glass, a major building energy efficiency improvement. Universal use (unachievable but a useful point of reference) could reduce total U.S. energy use by 5% (about 4… more
Abstract:Purpose: Instruction in English Language Arts (ELA) for students with severe intellectual disabilities and autism can be challenging, as these students often do not have the skills to engage with text. In recent years, special education experts have proposed a comprehensive approach to supporting… more
Abstract:USDA secretary, Tom Vilsack, has urged the Forest Service to "develop new markets" for forest by-products, which encourage healthy timber management. WholeTrees & reg; Structures (WT) is launching a manufacturing system that sources small diameter round timber from timber management… more
Abstract:Using a solvent free electrode manufacturing process, several different electrochemical couples will be tested using the C123 sized cell as the test bed. Both rechargeable and primary chemistries will be processed using the solventless electrode process that was successfully developed under a… more
Abstract:The broader impact/commercial potential of this project is in making structural simulation widely available to communities of makers, small businesses, and manufacturing enterprises, leading to dramatic improvements in performance, quality, manufacturability, and cost savings. If successful, the… more
Company:DAND FISH FARMAgency/Program/Year/Phase:USDA / SBIR / 2014 / 2
Abstract:Walleye are a valuable foodfish and sportfish in the North Central US. The overall goal of our project is to test the feasibility of combining selected new technologies for the commercial production of walleye for food fish and for extended growth fingerlings for stocking. For food fish production… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project investigates the merit of a novel capacitive generator design for use in the wind energy sector. The general design utilizes electric fields to exert forces on mechanical systems, a concept that is routine on the Microelectromechanical… more
Abstract:DESCRIPTION (provided by applicant): Seasonal influenza (flu) virus, an NIAID category C priority pathogen, causes widespread infection, resulting in at least 3-5 million cases of severe illness and 250,000-500,000 deaths worldwide. Young children and elderly or immunocompromised individuals are… more
Abstract:DESCRIPTION: Infections are a leading cause of mortality in adult and pediatric ICUs. Earlier diagnosis and treatment of infection could significantly reduce patient morbidity and mortality. Unfortunately, current methods of detection cannot routinely detect infection early in the disease course.… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel method to combat Erwinia amylovora (Ea), a causative agent of fire blight. Fire blight has emerged as the most devastating disease of apple and pear trees worldwide. Many growers apply streptomycin or… more
Abstract:This Small Business Innovation Research (SBIR) Phase 1 project will result in the design of materials for a unique microfilm dressing that synergistically employ antimicrobial and antibiofilm agents at the onset of wound treatment and immobilizes them on wound surface for sustained intimate contact.… more
Abstract:DESCRIPTION (provided by applicant): Clinical infections in burn, trauma and surgical wounds represent a huge economic and health care burden. In the U.S., there is a 2-5% infection rate in surgical wounds and up to a 20% rate in burn wounds. The current standard of care is intensive and expensive,… more
Abstract:This Small Business Innovation Research (SBIR) Phase I Project proposes to develop and deliver to health care enterprises a next generation imaging, analytics, and search solution that meets not only the current needs of multi-enterprise medical image viewing, but satisfies emerging demands related… more
Abstract:DESCRIPTION (provided by applicant): Cardiomyopathy has various forms including hypertrophic cardiomyopathy (HCM), 1 in 500 prevalence, could cause sudden cardiac death in athletes, Dilated Cardiomyopathy (DCM), 1 in 5000 prevalence, results in an enlargeleft ventricle, Arrhythmogenic Right… more
Abstract:The innovation is a high-frequency single-stage pulse tube cryocooler (PTC) that operates at a heat rejection temperature of 150 K. It employs a flexure-bearing cold compressor operating at that same heat rejection temperature. High frequency, low temperature pulse-tube cryocoolers are a promising… more
Abstract:DESCRIPTION (provided by applicant): Numerous preclinical studies have demonstrated multiple health benefits including anti- inflammatory, antioxidant, and chemopreventive effects of dietary polyphenols. These compounds are abundant in plants and have added to the health benefits of many fruits,… more
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