Abstract:We will commercialize a high-speed instrument for automated DNA sequence analysis. Such an instrument is essential to the success of the Human Genome Initiative; the sequence of the human genome will be determined and used as a powerful tool for biological and medical research. Two key aspects of… more
Abstract:THIS PROJECT WILL ATTEMPT TO COMMERCIALIZE A NOVEL, HIGH-SPEED, AND AUTOMATABLE DNA AND RNA DIAGNOSTIC TECHNOLOGY FOR THE SPECIFIC DETECTION OF NUCLEIC ACID SEQUENCE CHANGES ASSOCIATED WITH GENETIC DISEASES. THIS TECHNOLOGY IS BASED ON THE DISCOVERY THAT THE 5' NUCLEASE OF SEVERAL THERMOSTABLE DNA… more
Abstract:DESCRIBED IS A NEW LOW-COST DISPOSABLE BIOREACTOR FOR THE COMMERCIAL PRODUCTION OF PLANT CELL SUSPENSIONS IN VITRO. DETERMINATION OF THE TECHNICAL AND ECONOMIC POTENTIAL OF OUR NEW TECHNOLGY IS PROPOSED. DEVELOPED BY AGRESEARCH INTERNATIONAL, INC. AND BASED ON PRELIMINARY EXPERIMENTS, OUR NEW LOWER… more
Abstract:A NUMBER OF ORGANOPHOSPHORUS COMPOUNDS ARE HIGHLY TOXIC AS A RESULT OF THEIR ABILITY TO INHIBIT CHOLINESTERASES. THIS TOXICITY HAS LED TO THE WIDESPREAD USE OF THESE COMPOUNDS AS PESTICIDES AND SUGGESTS THEIR POTENTIAL USE AS AGENTS OF CHEMICAL WARFARE. A NUMBER OF BACTERIAL SPECIES ELABORATE… more
Abstract:We will develop new, very rapid bioluminescent mutagenicity tests that can be applied to purecompounds, complex chemical mixtures, process and drinking water and environmental samples. Thenew bioluminescent mutagenicity reporting system is designed to be used as a screening test. This testis not… more
Abstract:A program for the research/development of a reflective, near infrared glucose analyzer isproposed. The design approach allows for an optical computing approach to signal processing andpattern recognition that has the potential for a compact, low-cost instrument for diabetic hometesting.The basic… more
Abstract:This proposal represents a joint small business/university development effort to investigate the problem of plant health monitoring and to evolve a preliminary design of a spectral imaging system. Biotronics Technologies, as the small business SBIR proposer, has extensive background in the… more
Abstract:Surface Acoustic Wave (SAW) devices have shown some promise as specific gas detector/analyzers for a number of applications. These sensors operate as dual oscillators in which one SAW is coated with a sorbent material specific to c particular gas. The frequency of the coated oscillator changes with… more
Abstract:Site characterization to detect subsurface contamination is of a enormous interest for both public and private applications. Biotronics is proposing to adapt an arc excitation spectrometry technology originally developed for anlaysis of liquid nutrient solutions at NASA to the detection of heavy… more
Abstract:Our goal is to produce an economical stage control system that reduces the labor-intensity ofclinical microscopic testing (i.e., cytology, histology and cytogenetics). We will develop a new meansto optically detect position during microscopic examination. Optical positioning integrated… more
Abstract:The advent of genome analysis through molecular biology has brought into prospect thecomplete sequence analysis of the human genome and other species. The data is being gathered at anever increasing rate and the ways in which they will be analyzed are evolving even as it is beingcollected. The… more
Abstract:This grant will improve the software for DNA sequencing by integrating the components of basecalling, sequence assembly and post-assembly analysis into an integrated software system. To test theperformance of the software configurations, data for known regions of E. coli will be resequenced fromthe… more
Abstract:We propose to develop a new type of optical filter with these properties that is constructed using thin, alternating layers of dispersive and non-dispersive media. Like the classic interference filter, this device operates through the selective constructive and destructive interference of the… more
Abstract:Intelligible Voice communication in aviation systems is critical for efficient and safe performance. This work will develop a noise cancelling fiber optic microphone that can be used in electrically and acoustic noisy environments. Two pressure fiber optic microphones (FOM), a lens FOM and a shutter… more
Abstract:In situ immunological and DNA probe-based histochemical detection methods have widespread,important biomedical applications in infectious and genetic disease diagnosis, neurobiology,developmental biology, pharmacology and other research. However, radioisotopic detection remains thepredominant method… more
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