Abstract:With the increased understanding of the role of specific cytochrome P450 isoforms in drug metabolisgrowing need for improved in vitro methodology using purified P450s. The major drawbacks to currentinterference from contaminating enzymes present in heterogenous assay systemss and difficulties in… more
Abstract:Though radioactivity is widely used in bioassays due to its high sensitivity and convenience, safety and environmental concerns have accelerated efforts to eliminate its use. Recent procedures using luminescence have often surpassed conventional isotopic methods; among these the luminescence of… more
Abstract:Prenylation (the modification of proteins with the cholesterol biosynthesis intermediates C(15) fargeranylgeranyl) is a newly discovered postranslational modification that targets certain proteins tointerior of the cell, thereby regulating their biological activity. The best studied example… more
Abstract:Development of a more energy efficient plant irradiance source with high levels of safety, reliability, small volume and mass, and low maintenance would enhance basic plant science research in space and serve as key technology for a Closed Ecological Life Support System(CELSS). Recent advances in… more
Abstract:We will commercialize a high-speed instrument for automated DNA sequence analysis. Such an instrument is essential to the success of the Human Genome Initiative; the sequence of the human genome will be determined and used as a powerful tool for biological and medical research. Two key aspects of… more
Abstract:THIS PROJECT WILL ATTEMPT TO COMMERCIALIZE A NOVEL, HIGH-SPEED, AND AUTOMATABLE DNA AND RNA DIAGNOSTIC TECHNOLOGY FOR THE SPECIFIC DETECTION OF NUCLEIC ACID SEQUENCE CHANGES ASSOCIATED WITH GENETIC DISEASES. THIS TECHNOLOGY IS BASED ON THE DISCOVERY THAT THE 5' NUCLEASE OF SEVERAL THERMOSTABLE DNA… more
Abstract:DESCRIBED IS A NEW LOW-COST DISPOSABLE BIOREACTOR FOR THE COMMERCIAL PRODUCTION OF PLANT CELL SUSPENSIONS IN VITRO. DETERMINATION OF THE TECHNICAL AND ECONOMIC POTENTIAL OF OUR NEW TECHNOLGY IS PROPOSED. DEVELOPED BY AGRESEARCH INTERNATIONAL, INC. AND BASED ON PRELIMINARY EXPERIMENTS, OUR NEW LOWER… more
Abstract:A NUMBER OF ORGANOPHOSPHORUS COMPOUNDS ARE HIGHLY TOXIC AS A RESULT OF THEIR ABILITY TO INHIBIT CHOLINESTERASES. THIS TOXICITY HAS LED TO THE WIDESPREAD USE OF THESE COMPOUNDS AS PESTICIDES AND SUGGESTS THEIR POTENTIAL USE AS AGENTS OF CHEMICAL WARFARE. A NUMBER OF BACTERIAL SPECIES ELABORATE… more
Abstract:We will develop new, very rapid bioluminescent mutagenicity tests that can be applied to purecompounds, complex chemical mixtures, process and drinking water and environmental samples. Thenew bioluminescent mutagenicity reporting system is designed to be used as a screening test. This testis not… more
Abstract:A program for the research/development of a reflective, near infrared glucose analyzer isproposed. The design approach allows for an optical computing approach to signal processing andpattern recognition that has the potential for a compact, low-cost instrument for diabetic hometesting.The basic… more
Abstract:This proposal represents a joint small business/university development effort to investigate the problem of plant health monitoring and to evolve a preliminary design of a spectral imaging system. Biotronics Technologies, as the small business SBIR proposer, has extensive background in the… more
Abstract:Surface Acoustic Wave (SAW) devices have shown some promise as specific gas detector/analyzers for a number of applications. These sensors operate as dual oscillators in which one SAW is coated with a sorbent material specific to c particular gas. The frequency of the coated oscillator changes with… more
Abstract:Site characterization to detect subsurface contamination is of a enormous interest for both public and private applications. Biotronics is proposing to adapt an arc excitation spectrometry technology originally developed for anlaysis of liquid nutrient solutions at NASA to the detection of heavy… more
Abstract:Our goal is to produce an economical stage control system that reduces the labor-intensity ofclinical microscopic testing (i.e., cytology, histology and cytogenetics). We will develop a new meansto optically detect position during microscopic examination. Optical positioning integrated… more
Abstract:The advent of genome analysis through molecular biology has brought into prospect thecomplete sequence analysis of the human genome and other species. The data is being gathered at anever increasing rate and the ways in which they will be analyzed are evolving even as it is beingcollected. The… more
Abstract:This grant will improve the software for DNA sequencing by integrating the components of basecalling, sequence assembly and post-assembly analysis into an integrated software system. To test theperformance of the software configurations, data for known regions of E. coli will be resequenced fromthe… more
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