Abstract:This grant will improve the software for DNA sequencing by integrating the components of basecalling, sequence assembly and post-assembly analysis into an integrated software system. To test theperformance of the software configurations, data for known regions of E. coli will be resequenced fromthe… more
Abstract:We propose to develop a new type of optical filter with these properties that is constructed using thin, alternating layers of dispersive and non-dispersive media. Like the classic interference filter, this device operates through the selective constructive and destructive interference of the… more
Abstract:Intelligible Voice communication in aviation systems is critical for efficient and safe performance. This work will develop a noise cancelling fiber optic microphone that can be used in electrically and acoustic noisy environments. Two pressure fiber optic microphones (FOM), a lens FOM and a shutter… more
Abstract:In situ immunological and DNA probe-based histochemical detection methods have widespread,important biomedical applications in infectious and genetic disease diagnosis, neurobiology,developmental biology, pharmacology and other research. However, radioisotopic detection remains thepredominant method… more
Abstract:Helicobacter pylori is a gastrointestinal pathogen that causes, or is a major risk factor for thedevelopment of a spectrum of diseases including chronic gastritis, peptic ulcer, and cancer of thestomach. Current therapies for these diseases are inadequate as they are plagued with high… more
Abstract:ORBITEC proposes to develop an innovative Electromechanical Vibratory Tactile Stimulation (EVTS) system that will provide intuitive tactile, force, and torque feedback. The need for this type of feedback is growing, as manipulators become more dextrous, and more complex tasks are to be carried out… more
Abstract:PARKVIEW RESEARCH & DEVELOPMENT, INC., PROPOSES THE STUDY OF THREE-TERMINAL DEVICES BASED ON SMALL GRAIN THIN HTS FILMS AND STEP EDGE JUNCTION MATRICES. NEW CONFIGURATIONS AND MATERIALS THAT ARE BELIEVED TO SHOW HIGH MAGNETIC FIELD SENSITIVITY HAVE BEEN IDENTIFIED AND WILL BE EXPLORED. BECAUSE OF… more
Abstract:Biologically relevant environmental monitoring can be achieved using the genetic responses of microbes to environment conditions as sensors, particularly the specific and generalized responses to toxicity. The generalized toxicity response may be especially improtant when prior knowledge of the type… more
Abstract:Advanced aircraft designs require technology improvements that incorporate the use of advanced materials and material systems for high specific stiffness and temperature capabilities. Improved crack detection and material property measurement techniques are required to support the development and… more
Abstract:We will develop a novel system for directed nucleic acid cleavage. This system is based uponour discovery that the 5' nucleases of several thermostable DNA polymerases can be directed to cleaveas site-specific endonucleases. This system will be thermostable, specific, efficient and easilyautomatable… more
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