Abstract:DESCRIPTION (provided by applicant): Estrogen receptor a (ERa) is the major therapeutic target for breast cancer, and ERa binding at target genes in breast cancer cells is guided by DNA binding pioneer factor proteins such as FoxA1. Although tamoxifen is asuccessful therapeutic for suppressing… more
Abstract:DESCRIPTION (provided by applicant): A critical unmet need in implementing personalized medicine is the ability to sort through the millions of single nucleotide polymorphisms (SNPs) present in the human genome and to pinpoint which of these DNA variations are causative in disease. A key… more
Abstract:DESCRIPTION (provided by applicant): Harmful metals not readily detoxified naturally are discharged from numerous industrial activities and pose lasting environmental hazards requiring expensive remediation efforts. This project targets profitable dilute metal removal and reclamation. Creating an… more
Abstract:Copper is a commodity essential to modern society and its production is very energy intensive. Half of U.S. copper consumption goes to electrical, heating, and plumbing infrastructure in building construction and energy use for copper production topped 43 trillion BTUs in the early 1990s. Currently… more
Abstract:DESCRIPTION (provided by applicant): The overall goal of this SBIR Phase I proposal is to establish the measurement reliability and the clinical feasibility of the RGR-GAIT instrumented gait analysis system. Gait dysfunction can dramatically affect a person's ability to perform activities of… more
Abstract:DESCRIPTION (provided by applicant): Patient socket performance is a critical barrier to progress in rehabilitation, the most common source of patient dissatisfaction and part of a growing medical and socioeconomic problem. Poor socket performance is a greatly uncharacterized multi-factorial… more
Abstract:DESCRIPTION (provided by applicant): Prosthetics Our goal is to create a transtibial prosthesis in a kit that can be inexpensively manufactured using modern technology and advanced polymer materials. This system will be immediately fit on the residual limb and aligned for optimal gait without… more
Abstract:Obesity is a growing epidemic that continues to threaten the health of both adults and children around the world. Additionally, challenging economic times and increasing food costs puts pressure on consumers to purchase lower priced meals. While there are many ingredients available that can lower… more
Abstract:USDA secretary, Tom Vilsack recently urged the Forest Service to "develop new markets" for forest by-products, which encourage healthy timber management. Small-diameter round timber is an abundant by-product of healthy timber management and could serve emerging green commercial markets if… more
Abstract:The objective of this proposal is to analyze existing patent-pending nonpneumatic tires ("NPTs") to determine which designs and materials are best scalable across the full suite of the Family of Special Operations Vehicles Program. Resilient Technologies has produced functional NPT… more
Abstract:The Modulated Rotor Tip Light (MRTL) system provides greatly enhanced visibility because blade tip light paths appear very large, intensity and narrow field of view LED optics are used and lateral separation between red and green lights can be as much as five times larger than the fuselage width.… more
Abstract:The emergence of new generations of munitions and others military systems has created demand for adaptable high energy density power sources. Both batteries and energy harvesters have been used separately, but with limited success. The purpose of this program is to respond to this unmet need by… more
Abstract:The technical objectives of this proposal are: 1) the design of 8 micron-emitting active-photonic-crystal (APC) quantum-cascade (QC) lasers by using passive phase-locking in a monolithic structure in order to achieve multiwatt-range, diffraction-limited powers; and 2) the development of the key… more
Abstract:DESCRIPTION (provided by applicant): Reducing Health Disparities: A Health IT Solution, proposes a collaborative effort to coordinate community stakeholders in Dane County, WI, to integrate a replicable and innovative health IT solution to overcome syste
mic barriers that exacerbate health… more
Recent National Assessment of Educational Progress reports indicate that high percentages of students – especially English Language Learners, those with reading deficiencies, and those with… more
Recent National Assessment of Educational Progress reports indicate that high percentages of students – especially English Language Learners, those with reading deficiencies, and those with learning… more
Abstract:DESCRIPTION (provided by applicant): The Alzheimer's Association 2009 Alzheimer's Disease Facts and Figures report indicates that as many as 5.3 million Americans suffer from Alzheimer disease (AD), and it costs the country about 148 billion a year to pro
vide care. AD triples healthcare costs for… more
Abstract:DESCRIPTION (provided by applicant): Calorie restriction (CR) is the only non-genetic intervention known to increase maximum lifespan and oppose a broad spectrum of age-related diseases including diabetes, sarcopenia, cardiovascular disease and cancer. A m
arked characteristic of animals subjected… more
Abstract:The majority of manufactured parts for defense system applications are machined using a lubricating cutting fluid. Field data has shown that cutting fluids not only impact tool life and piece geometry of manufactured parts, but can alter the power used by machine tools by 15% to 30%. Cutting fluid… more
Abstract:This SBIR Phase I project will develop a plan to use a protein normally produced in plants, to control phytopathogenic fungi. They have cloned a gene that encodes for this protein, expressed it in bacterial vectors, demonstrated activity against three phytopathogenic fungi, demonstrated activity on… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project offers a substantial improvement in the surgical treatment of cancer. The inability to find malignant tissue by sight or touch limits the tissue that the surgeon can identify and remove. Currently, removal of affected tissue must be… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will determine feasibility of developing a radically new mechanical-to-electrical energy conversion method which is based on reverse electrowetting - a recently discovered novel microfluidic phenomenon. The approach is targeted towards… more
Abstract:DESCRIPTION (provided by applicant): Standard Imaging, Inc. is developing a new generation of radiation dosimeters for small field dosimetry, which are needed in clinical applications such as stereotactic radiosurgery/ stereotactic radiotherapy (SRS/SRT),
intensity modulated radiation therapy… more
Abstract:DESCRIPTION (provided by applicant): Hyperpolarized helium and xenon MRI of the lungs has been shown to provide useful physiological information about pulmonary function. Hyperpolarized helium imaging has been shown to provide outstanding imaging of lung g
as spaces while allowing for… more
Abstract:This Small Business Technology Transfer Phase I project will seek to improve the performance of the cathode materials used in lithium-ion (Li-ion) batteries. LiCoO2 is the primary cathode material, but it is relatively expensive, and has safety concerns. A safer alternative is LiMn2O4, but its… more
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