Abstract:This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a system that, while being inexpensive and simple to use, will be able to generate variable domains of heavy chain-only llama antibodies (also called VHHs, or nanobodies) targeted to antigens of interest in vitro… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project has a goal of creating a system that, while being inexpensive and simple to use, will be able to analyze samples for the presence of a live pathogenic bacteria and determine their species, as well as sensitivities to antibiotics within… more
Abstract:Current research tools to understand tumor cell migration and metastases are limited to linear gradients or constant flow across cells skewing results. Researchers at the National Institute of Standards and Technology developed a tool called the microfluidic palette which exposes cells to… more
Abstract:DESCRIPTION (provided by applicant): Key elements of tumorigenesis are driven by paracrine signaling between stromal and epithelial cells within the context of the extracellular matrix. Unfortunately, the cellular assays used for drug discovery typically r
ely on a single cell type grown as a… more
Abstract:DESCRIPTION (provided by applicant): There is a strong need for more predictive cellular assays that better represent the tissue that is under investigation. For airway epithelia such a model exists, and uses primary cells grown at an air liquid interface
(ALI). A key technical hurdle has been the… more
Abstract:The SPORL process consists of reacting wood chips with a solution of calcium, magnesium, or sulfite at elevated temperatures for a short time, and then size reducing the resulting material using a disk refiner to generate fibrous substrate for subsequent saccharification and fermentation. The work… more
Abstract:Brain tumor stem cells (BTSCs) are a subset population within tumors that are widely believed to be responsible for tumor recurrence, due to their ability to self-renew, differentiate, migrate, and initiate tumor propagation. Given these unique features, the selective targeting of… more
Abstract:CompuTherm, LLC proposes a pilot project to develop a modeling tool that can be used to assess the durability of environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) under combustion environment. This modeling tool is a package that integrates thermodynamic databases for the… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a universal, in vitro assay for determining the enzymatic activity of botulinum neurotoxin (BoNT)-based pharmaceuticals. BoNTs are used in many cosmetic and pharmaceutical applications due to their long lasting… more
Abstract:DESCRIPTION (provided by applicant): New interactive communication technologies continue to expand in modern society. Children and adolescents are frequently among the earliest adopters of new technologies. Communication via Short Message Service (SMS) te
xt messaging is one example. This… more
Abstract:DESCRIPTION (provided by applicant): Internet communication technologies facilitating one-to-one and many-to-one social and professional networks, and validated interactive computer-based assessments in support of clinical research and care have been avail
able for many years. Development of these… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase II SBIR proposal is to expand upon the research and development efforts, begun in Phase I, with new enhancements and product offerings, while also taking the initial steps to position the Company
for a multi-center clinical trial, planned… more
Abstract:DESCRIPTION (provided by applicant): Next-generation sequencing (NGS) platforms are fundamentally altering genetic and genomic research by providing massive amounts of data in a low-cost, high-throughput format. The main drawback of existing technologies i
s the short sequence read lengths they… more
Abstract:DESCRIPTION (provided by applicant): There is societal need for new antibiotic compounds in our arsenal of defenses against bacterial pathogens, many of which are increasingly resistant to existing antibiotics. The best possible source for new antibiotic s
tructures with potentially novel mechanisms… more
Abstract:DESCRIPTION (provided by applicant): G-Protein coupled receptors (GPCRs) are a large family of proteins expressed on the surface of eukaryotic cells. They are the major pathway for transducing extracellular signals into a diversity of intracellular respons
es. Because of their accessibility and… more
Abstract:DESCRIPTION (provided by applicant): The goal of this project is to integrate an isothermal amplification system with lateral flow detection to produce a simple, sensitive, low cost, all-in-one detection device for flaviviruse that is easily performed and
interpreted in a point of care setting and… more
Abstract:DESCRIPTION (provided by applicant): The goal of this Phase II proposal is to develop systems for transient, stable, and transgenic expression of nearly any DNA sequence, particularly those that are impossible to clone into current vectors. Primary tar
gets include genes containing long… more
Abstract:DESCRIPTION (provided by applicant): Xenotransplantation with pig organs offers the best near term hope for satisfying the limitation imposed by shortage of human organs. Although hyperacute rejection of pig organs in primate recipients has been overcomeby the production of (-1… more
Abstract:DESCRIPTION (provided by applicant): Novel Polymer Coatings to Prevent Biofilms on Urinary Stents and Catheters Bacterial infection and subsequent encrustation of urinary stents and catheters is a persistent problem in clinical urology and leads to signifi
cant patient morbidity and mortality. Most… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel biomimetic adhesive for seroma prevention. Commercial bioadhesives have demonstrated mixed results as they are hampered by weak adhesive strengths, the need to mix precursors, and undesirable degradation rates… more
Abstract:This Small Business Innovation Research Phase I project aims to design and develop an automated, behavior-based, malware analytics software system. This system addresses the growing problem of significant delay between a malware outbreak and the response from the IT security community. The response… more
Abstract:nPoint proposes to design and construct a closed-loop 2mm range-of-motion, 2-axis nano-positioning system with unprecedented precision and resolution. There is considerable need for such a tool in near-future nanomanufacturing, characterization, and lithography. One example is scanned-probe… more
Abstract:ORBITEC proposes to develop processes and waste heat recovery techniques to be incorporated into the existing Plastic Melt Waste Compactor (PMWC) to increase efficiency and throughput. The end goal will be to incorporate these processes and techniques into the PMWC system developed by Ames Research… more
Abstract:ORBITEC proposes to develop the Advanced Carbothermal Electric (ACE) reactor to efficiently extract oxygen from lunar regolith. Unlike state-of-the-art carbothermal reactors that use concentrated solar energy or laser energy to heat the regolith, the ACE reactor uses new innovative electric… more
Abstract:Challenges arise in the propulsion systems for the new exploration architecture. The currently operational and proven storable hypergolic systems raise toxicity concerns. Because MMH is a carcinogen, measures must be taken to prevent exposure of personnel to the fuel from the time of its synthesis… more
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