Abstract:Currently, the United States Army is investigating the application of chemiluminescent and bioluminescent immunoassay technologies for biological agent detection. Immunoassays offer the potential of highly specific screening for diverse organic and inorganic… more
Abstract:… sensing technology under investigation at the U.S. Naval Research Laboratory. Optical fibers will be tapered to allow light to "leak out their sides," interacting with immunochemical detection layers bonded to their surfaces. Relatively standard fluorescence immunoassay… more
Abstract:… in TSH, this assay represents a significant technical innovation. Because of its low cost andease of use, it will have considerable commercial application as a replacement for more expensive andcumbersome radio-, enzyme-linked, fluorescent, and chemiluminescent immunoassays… more
Abstract:Radioimmunoassays make up a significant percentage of the immunoassays used in clinicallaboratories. Nonradioactive, immunometric or "sandwich" assays using enzymes for signal generation(EIAs) have generally replaced radioimmunoassays for high molecular weight analytes. Low… more
Abstract:… input light. including absorption and fluorescence, are detected by a photodiode array. Selection of the transducer in each of the matrix regions will enable measurement of temperature, mass flow rates, pH, and chemical concentrations in gaseous or liquid media. Immunoassay… more
Abstract:FIBER-OPTIC SENSORS, IN CONJUNCTION WITH FLUORESCENCE SPECTROSCOPY, HAS MANY USES IN BIOCHEMISTRY, IMMUNOASSAYS, AND CLOSED-AQUACULTURE SYSTEMS. THE USE OF IN SITU FLUORESCENCE MEASUREMENT DURING FIELD TESTS IS HAMPERED BY THE PHYSICAL LIMITATIONS OF SPECTROMETERS RELATED TO… more
Abstract:…olerae (V. cholerae). Two major serotypes (Ogawa and Inaba) have been identified as defined by O antigens of lipopolysaccharide (LPS). Accurate serotyping and rapid identification of CT producing strains of V. cholerae by using monoclonal antibody based immunoassays are critical… more
Abstract:… include the susceptibility of HIV-infected persons, the lack of rapid and effective diagnostic tests, and recent outbreaks of drug-resistant strains. The objective of this award is to produce monoclonal antibodies for the development of diagnostic immunoassays for… more
Abstract:… EXIST FOR MONITORING HUMAN CYTOKINES, LITTLE OR NO ATTENTION HAS BEEN FOCUSED ON SUPPORTING BASIC CYTOKINE RESEARCH WITH ANALYTICAL SYSTEMS THAT EVALUATE MURINE CYTOKINES IN CULTURE MEDIA, AS WELL AS SERUM. THE SHORT-TERM GOAL IS TO DEVELOP AN ENZYME IMMUNOASSAY TO MEASURE… more
Abstract:…HE PRESENTLY AVAILABLEASSAYS ARE NOT BETTER PREDICTORS OF TAMOXIFEN RESPONSIVENESS. IT IS THE GOAL OF THIS PROJECT TO GENERATE MONOCLONAL ANTIBODIES SPECIFIC FOR THESE VARIOUS ISOFORMS AND TO SUBSEQUENTLY UTILIZE THESE ANTIBODIES TO DEVELOP ISOFORM-SPECIFIC IMMUNOASSAYS FOR… more
Abstract:… raised against an appropriately designed target structure (one that closely resembles the excited state emitter) may serve as a surrogate binding molecule. The resultant enhanced CL can then be extremely useful in a variety of applications, e. g. immunoassays. The… more
Abstract:… STEROIDS, IS THE GREAT UNLIKELIHOOD THAT ABUSERS WILL BE CAUGHT. DUE TO THE HIGH COSTS, TESTING IS INFREQUENT AND SPOTTY AT THE PROFESSIONAL AND COLLEGIATE LEVEL, AND NON-EXISTENT AT THE HIGH SCHOOL LEVEL. WE WILL DEVELOP AN INEXPENSIVE, RAPID EASY TO PERFORM ENZYME … more
Abstract:The overall objective is to develop highly stable electrochemical probes for the monitoring of the reduced cofactor nicotinamide adenine dinucleotide (NADH), which is produced in many enzyme-based immunoassays. These sensors can measure NADH concentrations at low applied… more
Abstract:A panel of "first generation" monoclonal antibodies (MAbs) has been developed which are directed to several distinct domains of the HTLV-1 surface protein. In addition, a sensitive chemiluminescent immunoassay has been constructed for the detection of HTLV-1 surface protein.… more
Abstract:… USUALLY NOT AVAILABLE IN CLINICAL LABORATORIES, AND ARE EXPENSIVE TO PERFORM. THE PURPOSE OF THIS PROJECT IS TO DELINEATE THE MOLECULAR DIFFERENCE BETWEEN THE NATIVE (PI 5.4) AND THE PI 5.7-TRANSFERRIN ISOFORM. BASED UPON THE MOLECULAR DIFFERENCE, AN IMMUNOASSAY WILL BE… more
Abstract:…ANTITIES OF THE EMBRYONIC HEMOGLOBIN ZETA-CHAIN. THE GOAL OF THE FIRST PHASE OF THIS PROJECT IS THE DEVELOPMENT OF A HYBRIDOMA PRODUCING MONOCLONAL ANTIBODIES TO HEMOGLOBIN ZETA-CHAINS. WITH SUCH AN ANTIBODY IT WILL BE POSSIBLE TO THEN DEVELOP AN ENZYME-LINKED IMMUNOASSAY WITH… more
Abstract:NEOGEN CORPORATION HAS DEVELOPED NUMEROUS IMMUNOASSAYS CURRENTLY IN WIDE COMMERCIAL PRACTICE TO DETECT AND QUANTIFY TOXIC RESIDUES (E.G. MYCOTOXINS, SULFONAMIDES). TECHNOLOGY IS CURRENTLY BEING DEVELOPED FOR DETECTING AND QUANTIFYING THE DEVELOPMENTALLY REGULATED ENZYME… more
Abstract:…the worse the prognosis. What is unclear is whether overall kinase amplification or the levels of activated kinase provides the better prognostic indicator. The major difficulty is the ability to specifically measure activated kinases. We will develop a two-site immunoassay to… more
Abstract:… WAS ORIGINALLY THOUGHT TO BE A DOMINANT ONCOGENE. HOWEVER, RECENT DATA SUGGEST THAT P53 IS A TUMOR SUPPRESSOR GENE. MANY PROPERTIES OF P53 PROTEIN ARE SIMILAR TO THOSE OF THE PROTOTYPE TUMOR SUPPRESSOR RB PROTEIN. WE HAVE RECENTLY DEVELOPED ANTI-RB MAB-BASED IMMUNOASSAYS TO… more
Abstract:…for clinical applications. We will focus on the production and purification of full-length AR proteins from insect cells infected with baculovirus vector carrying the AR gene; these proteins will be used as immunogens to produce high affinity anti-AR mAbs and develop … more
Abstract:… interface to increase sensitivity to small amounts of target analytes. The proposed detection scheme allows the possibility of sensing multiple bioagents simultaneously with a single sensor unit. Using POC's "substrate mode" waveguide sensor, well-developed immunoassay… more
Abstract:… DILATED CARDIOMYOPATHY. MEASUREMENT OF BETA RECEPOR ACTIVITY RESTS PREDOMINANTLY ON THE BINDING ASSAY, WHICH HAS SEVERAL LIMITATIONS AND IS OF LIMITED CLINICAL UTILITY. THE GOAL IS TO PRODUCE SPECIFIC ANTIBODIES TO THE BETA ADRENERGIC RECEPTORS AND TO DEVELOP IMMUNOASSAYS… more
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