Abstract:…he nature of DNpredictive of future breast cancer risk. These lesions are quantifiable using gas-chromatography-masHPLC analyses on isolated and derivatized DNAs. The objective is to develop DNA base lesion-specificantibodies to establish a quantitative immunoassay. Such an… more
Abstract:…scopysubstantial restraints on the required studies. Antibody based analytical methods have demonstratedfor both high throughput screening and quantitative analysis. This methodology can provide for a maranalytical effort through immunoaffinity purification and/or immunoassay… more
Abstract:… has been significantly enhanced through the use of the polymerase chain reaction (PCR). However, implementation of PCR can be expensive as well as equipment and expertise intensive. We have applied a technique with proven effectiveness in the field of immunoassays for the… more
Abstract:Enzymes used as the label for most non-radioactive assays and in biosensors, are the most unstable component of these systems. As immunoassays and biosensors move from the tightly controlled laboratory environment to demanding field conditions, the need for a more stable enzyme… more
Abstract:… antibodies by two- dimensional immunmatrix proteins extracted from colon cancer tissue, selected antibodies will be tested for tissue spimmunohistochemical localization of CC-4 or CC-5 antigens in stool or serum from colorectal cancer pblot and enzyme immunoassay.… more
Abstract:This research program seeks to develop an innovative and cost-effective in situ geo-environmental immunoassay technique (i) combined in a small, hydraulically driven geotechnical soil probe (e.g. BAT or mini cone, etc.) to detect, characterize, map and quantify, in real-time,… more
Abstract:THE LONG-TERM GOAL IS TO INCREASE THE SENSITIVITY AND RANGE OF APPLICATION OF CLINICAL CHEMILUMINESCENT IMMUNOASSAYS. SUBSTANTIAL PUBLIC BENEFITS COULD FOLLOW. SPECIFIC OBJECTIVES INCLUDE: (1) PREPARE PRELIMINARY ASSAY SUBSTRATES BY PLASMA SURFACE MODIFICATION, (2) TEST… more
Abstract:IMMUNOASSAY HAS PROVEN TO BE THE MOST SELECTIVE METHOD FOR DETECTION AND IDENTIFICATION OF BIOLOGICAL AGENTS. OPTICAL FLUOROIMMUNOASSAY (FIA), WITH SINGLE PHOTON COUNTING CAPABILITY, IS SUPPOSED TO BE THE MOST SENSITIVE TECHNIQUE. UNFORTUNATELY, DUE TO THE HIGH AUTOFLUORESCENT… more
Abstract:… using luminescence have often surpassed conventional isotopic methods; among these the luminescence of firefly luciferase is the most efficient. Relevant biomedical applications include reporter gene technology, viral and cell tracer methods, non-isotopic immunoassays and other… more
Abstract:…r diode light source in combination with a compact PIN photodiode receiver that synchronously and ratiometrically detects any fluorescence signal generated. A fiber optic cable will extend from the rear of each optoelectronic module to a remote want-shaped immunoassay detector… more
Abstract:Researchers at the National Institute of Standards and Technology (NIST) have recently developed a flow injection-based immunoassay which offers high sensitivity, reduced sample volume requirements and reasonable assay cycle times. This promising technology lends itself to… more
Abstract:… fluid. The sensor will be capable ofdetecting a specific immunological reaction between proteins immobilized onto the fiber sensor and theircorresponding binding partners in solution, without the requirements of molecular tagging employed inconventional immunoassay procedures.… more
Abstract:…ULD CAUSE THE PROPAGATION OF ACOUSTIC EMISSION SPECTRA DURING THE ANTIGEN-ANTIBODY REACTION. VERY PRELIMINARY EXPERIMENTAL DATA APPEARS TO SUPPORT THIS. THE PROJECT INTENDS TO DEMONSTRATE AND UTILIZE THIS PRINCIPLE VIA A METHOD TERMED ACOUSTIC EMISSION IMMUNOASSAY (AEI). THIS… more
Abstract:Our company will develop an immunoassay that can be used in screening programs fordetermination of blood lead levels. Monoclonal antibodies specific for delta-aminolevulinic acid (ALAD)and lead will be used to investigate the feasibility of their use for detection of lead bound… more
Abstract:THE LONG-TERM OBJECTIVE IS TO DEVELOP A RAPID ENZYME LINKED IMMUNOASSAY FOR TOXIGENIC CLOSTRIDIUM DIFFICILE. C. DIFFICILE IS THE MOST FREQUENT CAUSE OF ANTIBIOTIC-ASSOCIATED DIARRHEA AND COLITIS, AND THE MOST FREQUENTLY IDENTIFIED CAUSE OF ENTERIC DISEASE IN INDUSTRIALIZED… more
Abstract:… other malaria control interventions, are creating a demand for better diagnostictechnologies at both national and international program levels. Equal Access to Scientific Excellence(E.A.S.E.), a small business specializing in developing and manufacturing immunoassays, will… more
Abstract:THE OVERALL GOALS OF THIS PROJECT ARE TO DEVELOP IMMUNOASSAYS FOR THE DETECTION OF BRYOSTATIN 1 AND ITS ANALOGUES IN A VARIETY OF BIOLOGICAL MATRICES. THE BRYOSTATINS HAVE EXHIBITED STRONG ANTINEOPLASTIC ACTIVITY IN PRECLINICAL STUDIES AND ARE SCHEDULED TO ENTER PHASE I CLINICAL… more
Abstract:…. THE MEAN VALUE OF E1-G RISES BY A FACTOR OF THREE TWO DAYS PRIOR TO THE LH PEAK, BUT ITS MROE GRADUAL RISE REQUIRES A MORE QUANTITATIVE DETECTION DEVICE THAN THE ON OR OFF COLOR OTC LH TESTS. THIS OBSTACLE WILL BE OVERCOME BY EMPLOYING A NOVEL, COMPETITIVE, … more
Abstract:…, as well as a panel of non-prostate tissues. Antibodies selected for their ability to distinguishbetween cancerous and benign/normal prostate tissue will be used to search for PC-1 protein in urineor serum from prostate cancer patients by two site immunoassay. If… more
Abstract:THE USE OF ANTIBODIES IN COMMERCIAL IN VITRO IMMUNODIAGNOSTIC KITS AND IN OTHER RESEARCH IMMUNOASSAYS PLACES A REQUIREMENT ON ANTIBODY PRODUCTION FACILITIES AND RESEARCHERS TO PRODUCE SUITABLE HIGH TITERED POLYCLONAL AND MONOCLONAL ANTIBODIES. ADJUVANTS ARE USED TO INCREASE THE… more
Abstract:… antigens can be induced in a human neuroblastoma cell line. Phase I will expand on thisfinding by identifying more cell lines that express AD antigens, identifying cellular treatment conditionsthat affect expression, and by developing a rapid enzyme-linked immunoassay… more
Abstract:… studies on the physiologic andpathophysiologic roles of HODEs has been slowed by the lack of simple and convenient assays specificfor these compounds. Therefore, the ultimate goal of the present proposal is the development ofsensitive and specific immunoassays for these… more
Abstract:… disorders such as hepatorenal syndrome, rheumatoid arthritis, and carcinogenesis. Isoprostances have, thus far, been detected by mass spectrometry. However, this is an expensive method that is not well suited for routine clinical determinations. In contrast, immunoassay is… more
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