Abstract:… to integrate a novel containerless sample manipulator, laser beam heating, and an advanced data acquisition and management system with a high flux, high energy x-ray beamline. The R & amp;D will: (i) evaluate instrument requirements, (ii) design and construct a test… more
Abstract:…d reactive plasma arc welding techniques and consumables to improve joint quality. Work in the Phase I resulted in demonstration of 44 mm- by 3 mm thick full penetration fusion welds in ZrB2-20 v/o SiC and ZrB2-SiC-B4C composites. Two preheat furnaces were constructed to… more
Abstract:… has only been able to be fabricated through expensive micro/nano fabrication processes including photolithography, chemical etching, or time-consuming batch micro/nano molding processes. In this project, a pilot-scale manufacturing system will be constructed, optimized… more
Abstract:… from this coating technology. Research into very low friction water resistant skis would also have logical crossover into various marine areas. In addition, coatings with super-fluid repellent property can also provide tremendous value in textiles, construction materials,… more
Abstract:… achieve Milestone 2. The 3D human liver surrogates generated by this proposal will not only provide a valuable, commercializable tool for drug discovery and development, but can be extended to develop specific 3D human models of liver disease and implantable constructs for… more
Abstract:… with labtype hardware built with shortcuts to enable expeditious evaluation of the most fundamental design questions. Hardware to date has shown good hydraulic performance, low hemolysis, very long life and preliminary in vivo results, compromised by construction… more
Abstract:… and a novel nanoautomation process to enhance sensing characteristics for sensors targeted for metrology tools in the MEMS industry. The phase II program is planned as a build out phase to develop batch processes, work with early adopators in MEMS foundaries and construct a… more
Abstract:…n a novel Hla vaccine designed based on crystallographic structure. Two vaccine candidates have been designed that represent a structural domain at the N terminus of Hla involved in oligomerization: i) the N-terminal 62 amino acids of AT (AT-62aa) and ii) an extended construct… more
Abstract:… enabling the sequestration of toxins at site of infection, prevention of bacterial dissemination and toxemia, and efficient clearance of th bacteria and toxins by neutrophils. The proposal has two Specific Aims. In Aim 1, Tri-specific Zybodies will be constructed each of… more
Abstract:…, dynamic and fast approach for maximizing the ability of intelligence analysts to analyze text-based communication to assess the ever-changing content and trend. With DST, the evolution of the target topic is tracked in real-time. The text network is constructed and… more
Abstract:… topological data analysis, a method that focuses on recovering the topology of noisy data points, sampled from an unknown space, and embedded in a high-dimensional space. Based on our preliminary analysis in Phase I, we will continue our efforts for constructing combinatorial… more
Abstract:… ultra-high-speed, multi-channel, optical fiber sensor array system for acoustics measurements. The project goals are to design an ultra-high-speed/high resolution, small footprint fiber Bragg grating (FBG) acousto-optic sensor array plus the interrogator, construct a system… more
Abstract:… The ideal stiffness for each task also depends on the differing demands of dynamic and static stability. Based on studies of gait mechanics, both shape and stiffness should be adjusted for the task. The Specific Aims of this project are to: 1.To design and construct a… more
Abstract:Based on recently-developed InvenTek intellectual property, an opportunity exists to facilitate a revolutionary increase in power and energy for reserve battery with molten nitrate electrolyte that can be operated as a thermal battery. Simply put, there is an opportunity for advanced thermal… more
Abstract:DESCRIPTION (provided by applicant): ISS Inc., in collaboration with Dr. Franceschini of the Massachusetts General Hospital and Dr. Yodh of the University of Pennsylvania, proposes to develop and construct the prototype of a novel instrument to monitor cerebral oxygen metabolism… more
Abstract:…ht for same or greater strength. These materials hold great promise for creating much lighter and less bulky emergency rafts and life preservers. The reliable fabrication of these advanced materials are proposed to be developed and proven in order to make these constructions… more
Abstract:The overall success of future carbon cycle management will depend in part on reliable carbon dioxide (CO2) monitoring to support carbon cycle measurements. This SBIR Phase I proposal addresses development of an advanced, amperometric CO2 sensing technology that combines novel… more
Abstract:… in the human genome that allows the cell to discriminate between different linkages, i.e. Ub-binding domains (UbDs). In Phase I, we will identify and characterize novel UbDs exhibiting, at least, partial selectivity. In Phase II we will use these UbDs to construct higher… more
Abstract:… is to design a self-stabilized monolithic single frequency solid state laser. The main advantage of the approach is based on the integration of a laser cavity within active laser material - Nd-doped photo-thermo-refractive (PTR) glass, which allows constructing narrow… more
Abstract:Los Gatos Research (LGR) proposes to develop highly-accurate, lightweight, low-power gas analyzers for measurements of carbon dioxide (CO2) and water vapor (H2O) aboard NASAs Sensor Integrated Environmental Remote Research Aircraft (SIERRA) unmanned aerial… more
Abstract:A detailed understanding of carbon cycle is limited by the availability of rapid, accurate, and easy-to-use isotope analyzers. Researchers use stable isotope data to study: 1) recycling of CO2 within forests; 2) water use efficiency; 3) partitioning carbon exchange into its components; and 4)… more
Abstract:Recent work has shown that there are substantial methane and carbon dioxide emissions from microseepages of biogenic, thermogenic, and abiotic sources through the subsurface that are not included in the carbon balance. Research on microseeps with such low… more
Abstract:… technology is the development of a novel enzyme that converts RNA to DNA and isothermally amplifies it in minutes. These attributes have allowed the design of a device that does not use any microfluidics, pumps or valves. The greatly simplified construction… more
Abstract:… 113.5 kb) and novel genetic diversity not encountered before. Moreover, one of the clones was found to produce a novel chemical metabolite. These results are 10-100 fold more efficient than previous efforts. In Phase II a large metagenomic library will be constructed… more
Abstract:…he majority of this resource is currently burned as fuel. A report issued by the DOE in 2006 in response to The Energy Policy Act of 2005 Section 1838 highlights that the major impediment to expanding lube oil re-refining is investment costs required to design and construct new… more
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