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Company: Advanced Dynamics, Inc. Agency/Program/Year/Phase: DOD / STTR / 2010 / 1
Abstract: …aw containing the welded effects on aluminum alloys will also be taken into account; (2) an efficient meshfree contact algorithm for shear dominated ductile fracture under impact and thermo-mechanical loading will be developed; (3) a new meshfree ductile crack nucleation and… more
Company: ENGINEERING SOFTWARE RESEARCH & DEVELOPMENT, INC. Agency/Program/Year/Phase: DOD / SBIR / 2010 / 2
Abstract: The development of a procedural and computational framework for improved prediction of damage accumulation caused by cyclic loading in metallic airframe components is proposed. This framework will be based on the idea that models formulated for the prediction of crack nucleation… more
Company: GENE SECURITY NETWORK Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: … first trimester chorionic villus sampling (CVS) and second trimester amniocentesis are relatively safe, both procedures are not without negligible risks. In eff
orts to avoid these risks altogether, researchers have turned toward isolating circulating fetal nucleated red blood… more
Company: Global Engineering and Materials, Inc. Agency/Program/Year/Phase: DOD / STTR / 2010 / 1
Abstract: … following: 1) a new unified multi-scale fatigue crack growth modeling technique that incorporates micro-structural information obtained from Orientation imaging maps of polycrystalline alloys; 2) a novel multi-scale free energy based method for modeling crack/damage nucleation… more
Company: Foresite, Inc. Agency/Program/Year/Phase: DOD / STTR / 2010 / 2
Abstract: …, Inc., a consultant, laboratory and test equipment development company, has a goal for the subject research, in collaboration with Purdue University, to develop a valid, accelerated test that will measure the susceptibility of a surface to whisker nucleation and growth,… more
Company: NOVAN, INC. Agency/Program/Year/Phase: NSF / SBIR / 2010 / 1
Abstract: … main challenge is controlling the nanoparticle crystal size while maintaining high levels of nitric oxide storage. In this project, critical process parameters including reactant addition rate, reaction temperature and mixing rate will be studied. The Balanced-Nucleation… more
Company: Physical Sciences Inc. Agency/Program/Year/Phase: HHS / SBIR / 2010 / 1
Abstract: … uses 1 - 2 uL liquid product samples frozen between microscope slides resulting in a
frozen product thickness of 50 - 100 um. These samples are not representative of samples dried in vials which may have thicknesses of 5 - 50 mm. Thin films have different ice nucleation rates,… more
Company: Uncopiers, Inc. Agency/Program/Year/Phase: NSF / SBIR / 2010 / 1
Abstract: … cleaning of lithography masks, mems, solar cells, flat panel displays, HDDs, and precision optics. Ultimately, the principle of constructively controlled microcavitation relies on controlling the very fundamental process of phase change, the control of nucleation -- the… more
Company: Voxtel Inc. Agency/Program/Year/Phase: DOD / SBIR / 2010 / 2
Abstract: … electronic properties, and methods to separate nanotubes by their electronic properties remain expensive and small-scale. Accordingly, synthesis today entails high capital and operating costs. A process is proposed that sidesteps the most difficult problems in SWNT … more
Company: APES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2009 / 1
Abstract: …. Detection techniques provide the quantification necessary to complement the assessments by measurement of residual stresses. BENEFIT: AP/ES continues to focus on the research and development of analytical processes toward simulation of the fatigue process on nucleation,… more
Company: APES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2
Abstract: … the benefits of cold working in life extension and to guard against stress relaxation, the influence of cracks, and inadequate processing. BENEFIT: AP/ES continues to focus on the research and development of analytical processes that simulate fatigue from nucleation,… more
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2009 / 2
Abstract: … significant changes compared with both fresh controls and the -10:C storage group. Consistent storage of tissues without the antifree
ze proteins at -10:C was not possible because ~30% of the samples froze. The insect-derived antifreeze proteins inhibited ice nucleation at… more
Company: PROTHELIA INC. Agency/Program/Year/Phase: HHS / SBIR / 2009 / 1
Abstract: … preliminary data has demonstrated that multiple systemic doses of 1.0 mg/kg of the laminin isoform to dyW mice, the mouse model of MCD1A, result in distribution of the laminin isoform around skeletal myofibers, improved muscle morphology, r
educed centrally nucleated… more
Company: Foresite, Inc. Agency/Program/Year/Phase: DOD / STTR / 2009 / 1
Abstract: … of detrimental, process-related residues on electronic assemblies. Foresite research indicates a correlation between ionic residue levels and whisker growth, given prerequisite conditions, such as stress. The Phase I goal is to identify and rank tin whisker nucleation and… more
Company: NexGenSemi Corporation Agency/Program/Year/Phase: DOD / STTR / 2009 / 1
Abstract: …, dimensional control and other aspects of a production tool in conjunction with the core processes for fabrication of high-density MCOH nano-electronics. The Phase I study will focus on newer multi-activation processes performed post-exposure including nucleation deposition,… more
Company: QuesTek Innovations LLC Agency/Program/Year/Phase: NSF / SBIR / 2009 / 1
Abstract: …, high thermal conductivity, and elevated thermal-mechanical strength (fatigue resistance) required of high performance heat exchanger materials via a combination of L12-type and DO22-type precipitation. In Ni superalloys these two types of precipitates nucleate and grow in… more
Company: Scientific Forming Technologies Corporat Agency/Program/Year/Phase: DOD / STTR / 2009 / 2
Abstract: … design can mitigate this effect; for example, by increasing Zn content. However, this tends to relocate corrosion to the weld regions. Thus, more than alloy design, the most significant method to reduce this corrosion is to attract beta phase precipitates to nucleate on… more
Company: VEXTEC Corporation Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2
Abstract: Reusable life models rely on a large empirical database and require a lengthy development process. The models must be reconstructed for each new geometric and loading application. Rather than using empirical fatigue data to fit the model, the VEXTEC approach uses the intrinsic microstructure… more
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: …int depression produced by the insect antifreeze peptides that provide almost an ord
er of magnitude greater activity compared with other previously described antifreeze proteins derived from other sources. The insect-derived antifreeze proteins will inhibit ice nucleation at… more
Company: Los Gatos Research Agency/Program/Year/Phase: DOE / SBIR / 2008 / 2
Abstract: …, moderating climate warming. In laboratory experiments, sulfate aerosol formation depends, in a strong, non-linear manner, on ammonia concentrations. There are limited field-studies, and uncertainties are partially responsible for limitations in predicting aerosol nucleation… more
Company: ONE CELL SYSTEMS, INC Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: … of cellular development, gene expression or protein composition within the hematopoietic microenvironment have been difficult because of the relatively low cell frequency of megakaryoctyes:
megakaryocytes represent only 0.015% to 0.03% of the total number of nucleated… more
Company: Physical Optics Corporation Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: … they are not performed on all pregnant women. As a result, a large number of fetal genetic abno
rmalities, such as Down syndrome, are missed. Reliable methods of noninvasive prenatal diagnosis have long been sought in perinatal medicine. The presence of fetal nucleated red… more
Company: RAINDANCE TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / STTR / 2008 / 1
Abstract: …e candidate protein solution to different degrees of supersaturation for variable durations and t
hen reduces the supersaturation to a low value. The concept is to find the two-step kinetic pathway that firstly quenches the drop for the right amount of time to nucleate just a… more
Company: SNOWDON PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: …loid diseases are characterized by transformation of proteins from their proper native structure into an abnormal beta-rich structure known as amyloid fibril. This process is triggered by short peptide segments within the pol
ypeptide sequence called core nucleation motifs that… more
Company: TOPOGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: … anticancer agents and a number are FDA approved. Anti-topoisomerase therapy is predicated on subverting the endogenous topoisomerase into a genotoxic, DNA damaging ag
ent. A significant problem with such drugs is collateral damage in normal cells. Since all nucleated… more
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