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Displaying 51 – 75 of 241 Awards
Company: APES, INC. Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2
Abstract: … the benefits of cold working in life extension and to guard against stress relaxation, the influence of cracks, and inadequate processing. BENEFIT: AP/ES continues to focus on the research and development of analytical processes that simulate fatigue from nucleation,… more
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2009 / 2
Abstract: … significant changes compared with both fresh controls and the -10:C storage group. Consistent storage of tissues without the antifree ze proteins at -10:C was not possible because ~30% of the samples froze. The insect-derived antifreeze proteins inhibited ice nucleation at… more
Company: PROTHELIA INC. Agency/Program/Year/Phase: HHS / SBIR / 2009 / 1
Abstract: … preliminary data has demonstrated that multiple systemic doses of 1.0 mg/kg of the laminin isoform to dyW mice, the mouse model of MCD1A, result in distribution of the laminin isoform around skeletal myofibers, improved muscle morphology, r educed centrally nucleated… more
Company: Foresite, Inc. Agency/Program/Year/Phase: DOD / STTR / 2009 / 1
Abstract: … of detrimental, process-related residues on electronic assemblies. Foresite research indicates a correlation between ionic residue levels and whisker growth, given prerequisite conditions, such as stress. The Phase I goal is to identify and rank tin whisker nucleation and… more
Company: NexGenSemi Corporation Agency/Program/Year/Phase: DOD / STTR / 2009 / 1
Abstract: …, dimensional control and other aspects of a production tool in conjunction with the core processes for fabrication of high-density MCOH nano-electronics. The Phase I study will focus on newer multi-activation processes performed post-exposure including nucleation deposition,… more
Company: QuesTek Innovations LLC Agency/Program/Year/Phase: NSF / SBIR / 2009 / 1
Abstract: …, high thermal conductivity, and elevated thermal-mechanical strength (fatigue resistance) required of high performance heat exchanger materials via a combination of L12-type and DO22-type precipitation. In Ni superalloys these two types of precipitates nucleate and grow in… more
Company: Scientific Forming Technologies Corporat Agency/Program/Year/Phase: DOD / STTR / 2009 / 2
Abstract: … design can mitigate this effect; for example, by increasing Zn content. However, this tends to relocate corrosion to the weld regions. Thus, more than alloy design, the most significant method to reduce this corrosion is to attract beta phase precipitates to nucleate on… more
Company: VEXTEC Corporation Agency/Program/Year/Phase: DOD / SBIR / 2009 / 2
Abstract: Reusable life models rely on a large empirical database and require a lengthy development process. The models must be reconstructed for each new geometric and loading application. Rather than using empirical fatigue data to fit the model, the VEXTEC approach uses the intrinsic microstructure… more
Company: CELL AND TISSUE SYSTEMS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: …int depression produced by the insect antifreeze peptides that provide almost an ord er of magnitude greater activity compared with other previously described antifreeze proteins derived from other sources. The insect-derived antifreeze proteins will inhibit ice nucleation at… more
Company: LOS GATOS RESEARCH Agency/Program/Year/Phase: DOE / SBIR / 2008 / 2
Abstract: …, moderating climate warming. In laboratory experiments, sulfate aerosol formation depends, in a strong, non-linear manner, on ammonia concentrations. There are limited field-studies, and uncertainties are partially responsible for limitations in predicting aerosol nucleation… more
Company: ONE CELL SYSTEMS, INC Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: … of cellular development, gene expression or protein composition within the hematopoietic microenvironment have been difficult because of the relatively low cell frequency of megakaryoctyes: megakaryocytes represent only 0.015% to 0.03% of the total number of nucleated… more
Company: Physical Optics Corporation Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: … they are not performed on all pregnant women. As a result, a large number of fetal genetic abno rmalities, such as Down syndrome, are missed. Reliable methods of noninvasive prenatal diagnosis have long been sought in perinatal medicine. The presence of fetal nucleated red… more
Company: RAINDANCE TECHNOLOGIES, INC. Agency/Program/Year/Phase: HHS / STTR / 2008 / 1
Abstract: …e candidate protein solution to different degrees of supersaturation for variable durations and t hen reduces the supersaturation to a low value. The concept is to find the two-step kinetic pathway that firstly quenches the drop for the right amount of time to nucleate just a… more
Company: SNOWDON PHARMACEUTICALS, INC. Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: …loid diseases are characterized by transformation of proteins from their proper native structure into an abnormal beta-rich structure known as amyloid fibril. This process is triggered by short peptide segments within the pol ypeptide sequence called core nucleation motifs that… more
Company: TOPOGEN, INC. Agency/Program/Year/Phase: HHS / SBIR / 2008 / 1
Abstract: … anticancer agents and a number are FDA approved. Anti-topoisomerase therapy is predicated on subverting the endogenous topoisomerase into a genotoxic, DNA damaging ag ent. A significant problem with such drugs is collateral damage in normal cells. Since all nucleated… more
Company: VEXTEC Corporation Agency/Program/Year/Phase: DOD / SBIR / 2008 / 1
Abstract: Our commercial and military fleets operate safely but at a great cost. Downtime for structural inspections, elaborate sustainment equipment, long maintainer hours, expensive in-depot repair, continuous spectrum monitoring, and extensive component testing have effectively reduced the rates of… more
Company: VISTA ENGINEERING & CONSULTING, LLC Agency/Program/Year/Phase: DOD / SBIR / 2008 / 1
Abstract: … that make it environmentally stable, an excellent moisture barrier, and nonvolatile. These unique properties of the POSS feed stock present an unusual opportunity to the electronics industry; a conformal coating that also actively mitigates tin whisker nucleation and… more
Company: ADLYFE, INC. Agency/Program/Year/Phase: DOD / SBIR / 2007 / 2
Abstract: …abeled Pronucleon peptides that undergo conformational change in the presence of the misfolded infectious prion protein. The conformational peptide change is propagated throughout the ensemble of sequence specific Pronucleon peptides in the reaction via a nucleation event… more
Company: AMERICAN SUPERCONDUCTOR Agency/Program/Year/Phase: DOD / STTR / 2007 / 2
Abstract: … of 450 A/cm-width. This performance is equivalent to a current of 200 A in an industry standard 4.4 mm wide Second Generation (2G) superconducting wire. To achieve this successful result, the Phase I program focused on the characterization and optimization of the … more
Company: Brimrose Corporation of America Agency/Program/Year/Phase: DOD / STTR / 2007 / 1
Abstract: … method/s. The method consists of (a) Colloidal synthesis of CdTe nanocrystals, (b) Nanocrystalline film deposition by spin coating and (c) Chemical treatment of the film to remove the ligands and passivate the surface. MOCVD will be used first to nucleate, selectively… more
Company: Crystal IS, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2007 / 1
Abstract: … non-polar nitride crystals. Epitaxial growth optimization on non-polar substrates will be extensively investigated to produce device quality films and heterostructures required for high performance, long lifetime devices for next generation X-band radar system. Nucleation… more
Company: DXE LLC Agency/Program/Year/Phase: DOD / SBIR / 2007 / 1
Abstract: … health prediction in order to address this very issue. One way of accomplishing this is by developing methods to predict fatigue. This study will focus on measuring surface roughness of critical aircraft components and correlating it to fatigue crack nucleation. DXE, LLC.… more
Company: Fracture Analysis Consultants, Inc. Agency/Program/Year/Phase: DOD / SBIR / 2007 / 2
Abstract: … where cyclic loading leads to contact and slip between mating parts. For instance, the disk/blade assemblies in turbine engines suffer fretting at the dovetail contacts. In the proposed analysis methodology, an analytical model of fretting fatigue crack nucleation based on… more
Company: Integrated Sensing Systems Incorporated Agency/Program/Year/Phase: NSF / SBIR / 2007 / 1
Abstract: …nous drug lines is critical to preventing air embolisms and even death. Two-phase detection and damping problems have been reported in macroscopic Coriolis mass flow meters and in MEMS-based resonant tubes. There are experimental indications that microbubbles may be nucleating… more
Company: Kopin Corporation Agency/Program/Year/Phase: NSF / SBIR / 2007 / 1
Abstract: … of thermodynamically unstable InGaN alloy compositions. While the synthesis of high quality InN has proven challenging via standard growth techniques such as metalorganic chemical vapor deposition (MOCVD), our preliminary investigations have confirmed that InN nucleates… more
Displaying 51 – 75 of 241 Awards
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