Abstract:DESCRIPTION (provided by applicant): Molecular Express specializes in the design and engineering of functionalized liposomes for drug delivery and vaccine development. In previous studies, an extensive set of liposome formulations were screened to establish the optimal lipid combination that meets… more
Abstract:DESCRIPTION: In response to PA-10-150, we will test the hypothesis that the VesiVax(R) Conjugatable Adjuvant Lipid Vesicle (CALV) platform can provide an efficient method to develop carbohydrate conjugate vaccines that stimulates superior immune responsesto unconjugated carbohydrate antigens and… more
Abstract:Roll to Roll (R2R) printing, or web printing involves the patterning of flexible materials such as plastics or metal foils. R2R processing is in use today by industry and many R2R processes already exist for etch and deposition. However R2R patterning of arbitrary patterns with thin residual layer… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will develop the use of unique artificial protein sequences, known as entropic bristles, to accelerate the study of protein structure by the method of X-ray crystallography. Many interesting proteins have proven to be difficult to… more
Abstract:DESCRIPTION: Tracing neuronal connections with lipophilic carbocyanine dyes has revolutionized neuroanatomical tract tracing and is an essential feature to understand development of brain connections in both control and mutant mice in particular since multiple colors of dyes can be used. More… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project will establish the feasibility of developing a genetically-encoded biosensor to monitor levels of cyclic adenosine monophosphate (cAMP), an important second messenger component of drug signaling pathways. Unlike existing FRET-based… more
Abstract:Resodyn Corporation proposes to develop a novel cold chain system with a Lifetime Warranty for the vacuum container. The container composes a passive energy efficient system for transporting blood and pharmaceuticals in hostile environments for up to three days. Capacity is four 500 ml liter blood… more
Abstract:Resodyn Corporation proposes to develop a single tough thermoplastic polymer coating material and system solution for aluminum and composite boat hulls. The coating functions as an adhesive for attaching doubler plates. It encapsulates and prevents water from corroding metal substrates plus it is… more
Abstract:ABSTRACT: Resodyn Corporations proposed Functionalized Polyethylene (FPE) copolymer thermoplastic coating will overcome the shortcomings of the current ski coating. The FPE will provide the long-lasting, low friction, impact-resistant, abrasion resistant and hydrophobic properties required and… more
Abstract:Bonded composite materials offer considerable opportunity to reduce manufacturing cost, improve structural performance, and improve fuel efficiency of aircraft. However, bonded composite aircraft structures continue to be a challenge to manufacture due to the certification requirement to determine… more
Abstract:DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop a commercially-viable device that uses micro-scale acoustic streaming (low frequency sound energy) to deliver mixing to the interior of three-dimensional (3D) scaffolds used for tissue… more
Abstract:DESCRIPTION (provided by applicant): NeuroPlay Adventures addresses the need to develop innovative neuroscience educational tools to benefit children in kindergarten through 12th grade (K-12). The goals of this project are: (1) to develop mobile apps for tablets and smart phones and a web-site that… more
Abstract:ABSTRACT: In this program Morton Photonics will develop an Ultra-Low-Noise (ULN) Short Wave Infrared (SWIR) Hybrid Integrated Laser with low cost, size, weight and power (CSWAP) for operation between 1900nm and 2200nm. The ULN-SWIR laser is based on the hybrid-integration of a high-power SWIR… more
Abstract:This Small Business Innovation Program (SBIR) Phase I project will create a semiconductor-based laser with high power and the ultimate in low-noise performance besting all current semiconductor based lasers, and providing equivalent or better noise performance than the best fiber and solid-state… more
Abstract:Tactical Departure Scheduling (TDS) is a common activity in Air Traffic Control (ATC) in the National Airspace System (NAS) that requires significant coordination for individual flights and that has the potential to impose delay on impacted flights. Some of the delay that is imposed through the TDS… more
Abstract:The proposed innovation is an automated UAS mission planning system that will rapidly identify emergency (contingency) landing sites, manage contingency routing, and dynamically evaluate route changes for viability and safe operations in the NAS. Specifically, RAMPS will feature a pre-flight… more
Abstract:High performance LWIR detectors are highly needed. In order to image from long distance, it is important that imagers have high sensitivity, high resolution, and very low dark currents. This leads to technical goals of having low noise, low dark current in small size pixels in large arrays. While… more
Abstract:This proposal describes development of a new type of quantum-cascade laser for use as a local oscillator at frequencies above 2 THz. The THz source described is a single chip solution that operates at room temperature. In addition, a mechanism for wide tuning (2-4.7 THz) is described that requires… more
Abstract:High performance infrared detectors in the LWIR regime are highly needed in a number of missile defense missions. In order to image targets from long distance, it is important that imagers have high sensitivity and high resolution. This leads to technical goals of having low noise, low dark current… more
Abstract:Infrared countermeasure and standoff chemical detection applications require a light source with high power output, good beam quality, and a wide tuning range. There are a limited number of viable mid-infrared (3-5 micron wavelength) solutions that can provide these features in a compact and power… more
Abstract:Surface emitting semiconductor lasers eliminate the necessity for facet cleaving and allow for wafer scale testing, which increase the manufacturing yield and reduces the cost. However, in the mid-infrared, surface emitting semiconductor lasers are significantly underdeveloped compared to edge… more
Abstract:Existing ultraviolet laser diodes with wavelengths much shorter than 365 nm suffer from poor performance. This is partially due to limited research in this area, but a large part is also due to material and processing issues unique to deep UV lasers. New approaches to achieving 340 nm III-Nitride… more
Abstract:In atmospheric aerosol research, size-distributed aerosol samples are often collected with airborne instrumentation, but are not analyzed in any manner until after they are brought to a laboratory on the ground. The information thus obtained is averaged for all the locations covered during the… more
Abstract:DESCRIPTION (provided by applicant): This project will provide a significantly improved method for intra-pulmonary drug delivery in pediatric patients who are intubated or have a tracheostomy. Currently available aerosolizing devices are limited in that only certain agents and only a small fraction… more
Abstract:The U.S. DOE Office of Environmental Management (EM) was created in 1989 to manage the cleanup of large areas of environmentally contaminated sites. Since the closure of many of these sites, U.S. taxpayers have spent about $220 billion at 74 cleanup sites. However, these sites were the smallest and … more
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