Abstract:In this proposal, AlphaSense, Inc. details the development of a novel, low cost and handheld microwave sensor for the detection and evaluation of incipient composite heat damage. The merits of the proposed sensor and its advantages over other techniques are listed below: a) Compact, handheld and low… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims to develop a novel chemical sensor technology for inline water quality monitoring. Currently, gas chromatography coupled mass spectroscopy is the most widely used technique for water quality analysis; however, the method is costly,… more
Abstract:DESCRIPTION (provided by applicant): CD47 has emerged as a novel therapeutic target in hematologic cancers. Leukemias expressing the highest levels of CD47 have the worst prognosis. Increased CD47 expression is thought to protect cancer cells from phagocytic clearance by sending a don't eat me… more
Abstract:DESCRIPTION (provided by applicant): Organ transplantation is a lifesaving option for those with end stage renal disease. In spite of many improvements in organ procurement, transplant procedures and immune suppression, the damage done by ischemia-reperfusion injury (IRI) remains problematic,… more
Abstract:To produce drop-in biofuel from lignocellulosic biomass materials at prices competitive to fossil fuels requires consistent and reliable solid biomass feeders for pressurized reactors. Experience with coal has not been reliable, and the lower density and more irregular configurations of raw biomass… more
Abstract:Utilizing a dry cooling system for power plant condensers can reduce cooling system water need by over 90%, versus a wet cooling system, thereby reducing permitting and associated water use problems. However, by shifting from a wet to a dry cooling system, the volume, weight and cost of… more
Abstract:To meet the requirements of the Army Solid Waste Remediation System, for Small Contingency Base Camps, Altex has developed a Compact Ward Furnace Energy Recovery System (CWFERS), which was proven feasible by testing and analysis, under a Phase I award. The system reduces fuel consumption by 92%… more
Abstract:DESCRIPTION: AM Biotechnologies (AM) is developing an easy-to-use kit that enables a technician in a life science laboratory to rapidly develop renewable X-Aptamer (XA) affinity reagents at a reasonable price. Affinity reagents are widely used in research, diagnostic, and clinical applications.… more
Abstract:DESCRIPTION: New Reagents for RNA-based Therapeutic Technologies Abstract Functional RNA molecules such as aptamers, siRNAs, miRNAs, and related compounds have enormous potential as human therapeutics and as tools for elucidating gene regulation in vivo.To reach this potential, such molecules must… more
Abstract:Based on the successful Phase I results, The major objectives of the Phase II SBIR effort will be focused on further continuation and development of CDC compaction of W-25Re and other composite materials, processing optimization, fabricating test coupons and small scale throat/prototype large scale… more
Abstract:This Small Business Innovation Research (SBIR) Phase I project aims at developing a targeted semantic processing framework for the analysis of online conversations. A particular focus is given to improving the state-of-the art in the design of semi-supervised syntactic and semantic parsers capable… more
Abstract:The objective of this project is to demonstrate the feasibility of a miniature, MEMS IMU based, accurate isolation and stabilization system for beam pointing of a laser designator. Inertial stabilization and relative attitude control are the two key elements constituting the proposed accurate… more
Abstract:The objective of this project is to provide the Office of the Secretary of Defense a landing zones determination system for small autonomous air vehicles. The AGNC approach involves the use of EO sensors to effect video data collection and processing for determination of scene constituent elements… more
Abstract:The core project objective is to demonstrate the Graphical Evolutionary Hybrid Neuro-Observer (GNueroObs) System in conducting complex system workflow analysis for visualizing the interaction between components and subsystems. This software tool provides a state-of-the-art systems analysis framework… more
Abstract:The objective of Phase II is to provide a device capable of measuring, correlating, and logging a wide range of dynamic events for external store carriages and that is accompanied by a mobile data retrieval/logging tool and base station analysis software. For achieving this, AGNC is providing the U… more
Abstract:This Small Business Innovation Research (SBIR) Phase II project addresses the analysis needs for monitoring perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in water. PFOA and PFOS are ubiquitous environmental contaminants that have been found at low concentrations in waste… more
Abstract:Obsolescence, aging, reliability, and performance issues are driving nuclear facilities to replace conventional analog I & amp;C systems with digital technologies. The increased complexity of digital systems, compared to their analog counterparts, has resulted in faults that are often more… more
Abstract:No method currently exists for detecting intermittent faults in nuclear power plant cable circuits, which include circuit components, connectors, and end devices. Conventional techniques can locate hard faults, such as open or short circuits, but not the intermittent faults that occur … more
Abstract:In the U.S., almost all the 104 operating commercial nuclear power plants have applied or plan to apply for license renewal, many of which have recently received approval. This has given rise to questions about the aging of structures, systems, and components (SSCs) that are important to plant… more
Abstract:Small Modular Reactors (SMRs) are one of the most compelling options for meeting the growing clean energy demands of the U.S. While safer and costing less to build and operate than their conventional counterparts, the unique requirements of SMRs pose significant challenges to the maintenance of… more
Abstract:A light water reactor is equipped with control and shutdown rods which are inserted into and withdrawn from the reactor core to control reactivity. The positioning of the control and shutdown rods is performed in Combustion Engineering designed plants with the control element drive mechanism… more
Abstract:Our system concept is based on a number of ultra-low power"remote nodes"that contain: (1) a battery section; (2) a sensor section (3) and electronics section. The remote nodes will automatically detect and classify high value targets to type using AD & D"s proven automated… more
Abstract:Reliable, readily-manufacturable technologies are needed to create the next generation of high-density, high-functionality 3D integrated circuits (ICs) for integrating silicon pixel detectors with CMOS read-out ICs. Current methods for 3D IC development are severely limited by the thickness of the… more
Abstract:DESCRIPTION (provided by applicant): Multiple sclerosis (MS) affects 1 in 1000 individuals in the US and is characterized by progressive sensory, motor and cognitive impairments. These functional deficits are linked to inflammatory attacks on myelin, oligodendrocytes, and axons. Therapeutic… more
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